Protein: PERF
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Gene: PERF, PRF1
Organism: Homo sapiens
Interactions: 53
UniProt ID: P14222

Gene Ontology (top 5):
GO:0001771 - immunological synapse formation
GO:0001772 - immunological synapse
GO:0001913 - T cell mediated cytotoxicity
GO:0002357 - defense response to tumor cell
GO:0002418 - immune response to tumor cell

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571222

PERF
Perforin-1

2

4

Small-scale

0.821

High

571235

K1H1
Keratin, type I cuticular Ha1

3

1

High-throughput

0.675

High

168372

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

571236

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.656

High

571249

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

571256

BTNL2
Butyrophilin-like protein 2

1

0

High-throughput

0.656

High

571228

CALR
Calreticulin

1

0

Small-scale

0.537

High

380252

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

1

High-throughput

0.536

High

438866

CD1A
T-cell surface glycoprotein CD1a

1

2

High-throughput

0.536

High

568032

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

1

High-throughput

0.536

High

571224

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

571233

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.536

High

571242

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.536

High

571245

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.536

High

571250

CST11
Cystatin-11

1

1

High-throughput

0.536

High

516958

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.515

High

341282

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

342503

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.513

High

547959

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

567790

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

571226

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.513

High

571227

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

571229

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

571230

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.513

High

571234

PTC1
Protein patched homolog 1

1

0

High-throughput

0.513

High

571237

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

0

High-throughput

0.513

High

571238

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

571241

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.513

High

571243

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

571244

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

571246

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.513

High

571253

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

571257

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.513

High

571251

KLK15
Kallikrein-15

1

1

High-throughput

0.489

High

300294

KRT34
Keratin, type I cuticular Ha4

1

1

High-throughput

0.481

High

571231

KR108
Keratin-associated protein 10-8

1

2

High-throughput

0.481

High

571232

KRA11
Keratin-associated protein 1-1

1

2

High-throughput

0.481

High

571239

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.481

High

571240

KRA13
Keratin-associated protein 1-3

1

2

High-throughput

0.481

High

518730

GRAB
Granzyme B

1

1

Small-scale

0.479

High

571254

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

518648

SRGN
Serglycin

1

0

Small-scale

0.458

High

571225

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

380519

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

1

High-throughput

0.445

High

571248

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.438

High

70103

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

571247

TRI54
Tripartite motif-containing protein 54

1

0

Small-scale

0.288

High

164760

GDF8
Growth/differentiation factor 8

1

0

High-throughput

0.279

Low

571223

CRIS2
Cysteine-rich secretory protein 2

1

0

High-throughput

0.279

Low

571252

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

571255

DNJB9
DnaJ homolog subfamily B member 9

1

0

High-throughput

0.279

Low

472

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025