Protein: MEGF8
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)

Gene: MEGF8
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q7Z7M0

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003143 - embryonic heart tube morphogenesis
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0007224 - smoothened signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1281706

PSG8
Pregnancy-specific beta-1-glycoprotein 8

3

15

High-throughput

0.765

High

1158733

PSG3
Pregnancy-specific beta-1-glycoprotein 3

3

16

High-throughput

0.751

High

543427

PSG1
Pregnancy-specific beta-1-glycoprotein 1

2

14

High-throughput

0.726

High

1281702

TMPS4
Transmembrane protease serine 4

1

20

High-throughput

0.665

High

244476

MGRN1
E3 ubiquitin-protein ligase MGRN1

3

4

High-throughput

0.662

High

1281699

SIRPD
Signal-regulatory protein delta

1

4

High-throughput

0.618

High

1281704

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.618

High

188921

TMPS2
Transmembrane protease serine 2

1

20

High-throughput

0.618

High

1144623

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

10

High-throughput

0.618

High

1281690

TM11B
Transmembrane protease serine 11B

1

19

High-throughput

0.618

High

570688

EDN3
Endothelin-3

2

7

High-throughput

0.601

High

1281691

ANR46
Ankyrin repeat domain-containing protein 46

2

13

High-throughput

0.601

High

1281705

FBX2
F-box only protein 2

2

20

High-throughput

0.601

High

184723

ATX7
Ataxin-7

1

11

High-throughput

0.573

High

1281701

FBX6
F-box only protein 6

2

20

High-throughput

0.571

High

1160405

TAZ
Tafazzin

2

2

High-throughput

0.558

High

139719

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

11

High-throughput

0.552

High

651600

IBP4
Insulin-like growth factor-binding protein 4

2

20

High-throughput

0.549

High

1281692

LYPD1
Ly6/PLAUR domain-containing protein 1

2

9

High-throughput

0.549

High

885318

HXA1
Homeobox protein Hox-A1

1

11

High-throughput

0.541

High

607383

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

3

High-throughput

0.536

High

880032

DNSL1
Deoxyribonuclease-1-like 1

1

3

High-throughput

0.536

High

908635

PRELP
Prolargin

1

6

High-throughput

0.536

High

933192

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

8

High-throughput

0.536

High

1030182

IL5RA
Interleukin-5 receptor subunit alpha

1

12

High-throughput

0.536

High

1281696

GGH
Gamma-glutamyl hydrolase

1

6

High-throughput

0.536

High

1281700

SDF2L
Stromal cell-derived factor 2-like protein 1

1

7

High-throughput

0.536

High

399454

TRGV3
T cell receptor gamma variable 3

1

1

High-throughput

0.514

High

928296

ATN1
Atrophin-1

1

20

High-throughput

0.508

High

1217736

GFI1B
Zinc finger protein Gfi-1b

1

20

High-throughput

0.508

High

164770

GDF8
Growth/differentiation factor 8

1

9

High-throughput

0.489

High

426110

PPB1
Alkaline phosphatase, placental type

1

2

High-throughput

0.489

High

506866

CFC1
Cryptic protein

1

9

High-throughput

0.489

High

531993

PPBN
Alkaline phosphatase, germ cell type

1

2

High-throughput

0.489

High

548046

PSPC
Surfactant protein C

1

3

High-throughput

0.489

High

561371

TDGF1
Protein Cripto

1

9

High-throughput

0.489

High

956076

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.489

High

1281693

FIBIN
Fin bud initiation factor homolog

1

4

High-throughput

0.489

High

1281697

ESPB1
Epididymal sperm-binding protein 1

1

13

High-throughput

0.489

High

1281703

CBLN4
Cerebellin-4

1

20

High-throughput

0.489

High

242150

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

404172

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

693016

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

790919

TAGL2
Transgelin-2

1

2

High-throughput

0.479

High

901354

RAB7A
Ras-related protein Rab-7a

1

15

High-throughput

0.479

High

1049498

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

1113550

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1281698

RN157
E3 ubiquitin ligase RNF157

1

4

Small-scale

0.479

High

170843

CLGN
Calmegin

1

15

High-throughput

0.445

High

1010936

BAT1
b(0,+)-type amino acid transporter 1

1

8

High-throughput

0.445

High

1060364

SLC31
Amino acid transporter heavy chain SLC3A1

1

3

High-throughput

0.445

High

1280789

S35E3
Solute carrier family 35 member E3

1

1

High-throughput

0.445

High

218393

TGON2
Trans-Golgi network integral membrane protein 2

1

17

High-throughput

0.437

High

73827

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.407

High

976829

LCN6
Epididymal-specific lipocalin-6

1

6

High-throughput

0.407

High

1281694

CA054
Uncharacterized protein C1orf54

1

7

High-throughput

0.407

High

1281695

PATE1
Prostate and testis expressed protein 1

1

7

High-throughput

0.407

High

1281707

PRG3
Proteoglycan 3

1

20

High-throughput

0.407

High

1181077

DB109
Beta-defensin 109B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025