Protein: UTP25
U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component)

Gene: UTP25
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q68CQ4

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0019843 - rRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

960455

PSME3
Proteasome activator complex subunit 3

4

0

High-throughput

0.664

High

1228311

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

3

2

High-throughput

0.662

High

1228333

SAS10
Something about silencing protein 10

3

1

High-throughput

0.656

High

1228336

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

3

0

High-throughput

0.638

High

732625

ARRB2
Beta-arrestin-2

3

0

High-throughput

0.634

High

848880

MAGAB
Melanoma-associated antigen 11

2

0

High-throughput

0.618

High

1228343

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

3

High-throughput

0.617

High

140597

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

2

1

High-throughput

0.611

High

1228314

ZBT10
Zinc finger and BTB domain-containing protein 10

2

1

High-throughput

0.606

High

1228332

SSF1
Suppressor of SWI4 1 homolog

2

0

High-throughput

0.602

High

643894

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.559

High

978999

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

1178766

AAK1
AP2-associated protein kinase 1

2

2

High-throughput

0.558

High

1228322

TRIM9
E3 ubiquitin-protein ligase TRIM9

2

2

High-throughput

0.553

High

396307

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1144025

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1203859

NOM1
Nucleolar MIF4G domain-containing protein 1

1

1

High-throughput

0.536

High

1228315

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.536

High

1228345

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

603658

JUNB
Transcription factor JunB

1

0

High-throughput

0.513

High

777299

AHR
Aryl hydrocarbon receptor

1

0

High-throughput

0.513

High

1160816

MAPK3
MAP kinase-activated protein kinase 3

1

0

High-throughput

0.513

High

1228300

ZBT49
Zinc finger and BTB domain-containing protein 49

1

0

High-throughput

0.513

High

1228337

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1228338

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

1228299

L2GL2
LLGL scribble cell polarity complex component 2

1

1

High-throughput

0.489

High

1228304

SYT9
Synaptotagmin-9

1

1

High-throughput

0.489

High

1228307

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

1228305

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1228324

DDX47
Probable ATP-dependent RNA helicase DDX47

1

1

High-throughput

0.479

High

1228327

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.479

High

1228334

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1228339

AATF
Protein AATF

1

1

High-throughput

0.479

High

1228298

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1146918

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.460

High

241980

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

247958

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

372278

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

588912

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695697

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768414

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

937782

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

982703

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1228297

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.458

High

1228306

RM43
Large ribosomal subunit protein mL43

1

0

High-throughput

0.458

High

1228317

NP1L4
Nucleosome assembly protein 1-like 4

1

0

High-throughput

0.458

High

1228320

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1228321

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.458

High

1228328

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.458

High

1228329

SP110
Sp110 nuclear body protein

1

0

High-throughput

0.458

High

1228331

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1228340

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.458

High

1228341

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1228342

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

893929

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

323738

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.437

High

344713

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.437

High

922584

AP2S1
AP-2 complex subunit sigma

1

1

High-throughput

0.437

High

989006

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.437

High

1228301

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1228335

BMP2K
BMP-2-inducible protein kinase

1

2

High-throughput

0.437

High

1228308

CEP70
Centrosomal protein of 70 kDa

5

0

High-throughput

0.376

High

1228316

RUFY1
RUN and FYVE domain-containing protein 1

5

0

High-throughput

0.376

High

1228313

AP2M1
AP-2 complex subunit mu

5

0

High-throughput

0.374

High

1228310

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.337

High

628625

CAP7
Azurocidin

2

0

High-throughput

0.318

High

1228319

TRI62
E3 ubiquitin-protein ligase TRIM62

2

0

High-throughput

0.316

High

164768

GDF8
Growth/differentiation factor 8

1

0

High-throughput

0.279

Low

649333

H1T
Histone H1t

1

0

High-throughput

0.279

Low

665613

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.279

Low

846757

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.279

Low

939508

FCGRN
IgG receptor FcRn large subunit p51

1

0

High-throughput

0.279

Low

1052876

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.279

Low

1128639

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

1228303

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.279

Low

1228309

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

0

High-throughput

0.279

Low

1228312

ZN653
Zinc finger protein 653

1

0

High-throughput

0.279

Low

1228318

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

0

High-throughput

0.279

Low

1228323

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

1228330

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low

1228346

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

422307

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

412085

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

970650

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1140413

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1228302

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1228325

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.249

Low

1228326

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

516100

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

881665

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.232

Low

1064995

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.232

Low

1228344

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025