Protein: PPM1K
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)

Gene: PPM1K
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q8N3J5

Gene Ontology (top 5):
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0009083 - branched-chain amino acid catabolic process
GO:0030145 - manganese ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1107427

BIRC2
Baculoviral IAP repeat-containing protein 2

4

1

High-throughput

0.808

High

539365

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

6

0

High-throughput

0.701

High

554815

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

6

0

High-throughput

0.701

High

1022745

XIAP
E3 ubiquitin-protein ligase XIAP

2

1

High-throughput

0.700

High

642104

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

5

0

High-throughput

0.688

High

881564

CDK8
Cyclin-dependent kinase 8

1

8

High-throughput

0.618

High

1325206

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

3

High-throughput

0.618

High

848899

MAGAB
Melanoma-associated antigen 11

2

2

High-throughput

0.553

High

519402

MYB
Transcriptional activator Myb

1

2

High-throughput

0.494

High

641623

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.494

High

1101754

PTK7
Inactive tyrosine-protein kinase 7

1

7

High-throughput

0.494

High

1251927

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

1310854

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.494

High

358745

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.493

High

1325207

ENAH
Protein enabled homolog

1

2

High-throughput

0.489

High

166682

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.479

High

282005

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

575164

IDE
Insulin-degrading enzyme

1

3

High-throughput

0.479

High

1083667

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1206229

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.479

High

1325210

MY15B
Unconventional myosin-XVB

1

2

High-throughput

0.470

High

1156307

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

275063

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

1058135

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1325208

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1325211

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.458

High

269285

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

1211746

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.316

High

1290540

ZN410
Zinc finger protein 410

2

0

High-throughput

0.316

High

1325209

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

243973

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.279

Low

648198

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.249

Low

809722

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.249

Low

1241450

XRRA1
X-ray radiation resistance-associated protein 1

1

0

High-throughput

0.249

Low

1325212

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025