Protein: APC4
Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)

Gene: APC4, ANAPC4
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9UJX5

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

251820

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

19

2

Small-scale

0.986

High

1460765

ANC2
Anaphase-promoting complex subunit 2

10

3

Small-scale

0.973

High

1460754

APC5
Anaphase-promoting complex subunit 5

10

1

Small-scale

0.969

High

224391

BUB3
Mitotic checkpoint protein BUB3

8

1

Small-scale

0.960

High

1460764

APC4
Anaphase-promoting complex subunit 4

4

1

Small-scale

0.867

High

718654

CDC27
Cell division cycle protein 27 homolog

33

9

Small-scale

0.769

High

1086933

CDC20
Cell division cycle protein 20 homolog

26

7

Small-scale

0.766

High

1093081

CDC16
Cell division cycle protein 16 homolog

15

11

Small-scale

0.762

High

1099813

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

15

1

Small-scale

0.760

High

1460746

APC7
Anaphase-promoting complex subunit 7

11

11

Small-scale

0.754

High

1460767

FZR1
Fizzy-related protein homolog

10

7

Small-scale

0.753

High

1460722

CDC23
Cell division cycle protein 23 homolog

10

11

Small-scale

0.752

High

1430911

APC1
Anaphase-promoting complex subunit 1

10

1

Small-scale

0.749

High

1452594

APC11
Anaphase-promoting complex subunit 11

9

1

Small-scale

0.749

High

1460768

APC10
Anaphase-promoting complex subunit 10

8

3

Small-scale

0.745

High

948606

APC15
Anaphase-promoting complex subunit 15

10

0

Small-scale

0.720

High

1340921

CDC26
Anaphase-promoting complex subunit CDC26

10

0

Small-scale

0.719

High

1412129

APC13
Anaphase-promoting complex subunit 13

9

0

Small-scale

0.719

High

1387380

APC16
Anaphase-promoting complex subunit 16

9

0

Small-scale

0.716

High

908871

NEK2
Serine/threonine-protein kinase Nek2

6

0

Small-scale

0.699

High

224177

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

2

High-throughput

0.691

High

1352281

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.691

High

1460766

FBX5
F-box only protein 5

5

0

Small-scale

0.689

High

573906

CCNB1
G2/mitotic-specific cyclin-B1

3

2

Small-scale

0.640

High

629172

CCNA2
Cyclin-A2

3

2

Small-scale

0.640

High

725815

RIR2
Ribonucleoside-diphosphate reductase subunit M2

3

0

High-throughput

0.638

High

1341368

KI18A
Kinesin-like protein KIF18A

2

2

Small-scale

0.628

High

1339023

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.618

High

1116111

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.611

High

1195402

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

316132

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.586

High

1114609

CUL3
Cullin-3

1

0

High-throughput

0.586

High

1310810

CUL9
Cullin-9

1

0

Small-scale

0.586

High

1406466

LYST
Lysosomal-trafficking regulator

1

1

Small-scale

0.553

High

1384295

SH3K1
SH3 domain-containing kinase-binding protein 1

2

0

High-throughput

0.547

High

1385536

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.536

High

951897

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.530

High

419265

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.513

High

788809

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

872864

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

884266

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

940471

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.513

High

992376

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1163274

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1210553

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1312885

KLHL7
Kelch-like protein 7

1

0

High-throughput

0.513

High

1407625

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.513

High

1452466

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.513

High

1007659

CCNA1
Cyclin-A1

1

2

Small-scale

0.501

High

595635

H15
Histone H1.5

1

0

High-throughput

0.493

High

734026

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.489

High

1260719

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

1

High-throughput

0.489

High

353828

PTTG1
Securin

1

0

Small-scale

0.480

High

993803

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1136761

MD2BP
MAD2L1-binding protein

1

0

Small-scale

0.480

High

1162718

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

173525

XPO1
Exportin-1

1

2

High-throughput

0.479

High

331608

KIF4A
Chromosome-associated kinesin KIF4A

1

2

Small-scale

0.479

High

408188

TBB4A
Tubulin beta-4A chain

1

1

Small-scale

0.479

High

543298

UBL4A
Ubiquitin-like protein 4A

1

1

Small-scale

0.479

High

835119

EIF1
Eukaryotic translation initiation factor 1

1

1

Small-scale

0.479

High

958732

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.479

High

1089056

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1129780

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

1257163

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1294895

KI18B
Kinesin-like protein KIF18B

1

1

Small-scale

0.479

High

1406275

KIF2C
Kinesin-like protein KIF2C

1

3

Small-scale

0.479

High

1415131

TBB2B
Tubulin beta-2B chain

1

1

Small-scale

0.479

High

1460280

XPO7
Exportin-7

1

2

High-throughput

0.479

High

238637

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

342361

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

443551

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

700753

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

769468

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

771616

HXD13
Homeobox protein Hox-D13

1

0

Small-scale

0.458

High

799561

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

874206

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.458

High

896211

MXI1
Max-interacting protein 1

1

0

Small-scale

0.458

High

905701

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.458

High

916059

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

Small-scale

0.458

High

920347

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

986802

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

994414

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

1005229

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1033812

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1040504

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

0

Small-scale

0.458

High

1060140

BAX
Apoptosis regulator BAX

1

0

Small-scale

0.458

High

1147875

DHC24
Delta(24)-sterol reductase

1

0

Small-scale

0.458

High

1214598

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1259560

TBA1A
Tubulin alpha-1A chain

1

0

Small-scale

0.458

High

1287026

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.458

High

1289700

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1313512

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1329933

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1336185

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

Small-scale

0.458

High

1336879

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1338425

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1339221

NUP35
Nucleoporin NUP35

1

0

Small-scale

0.458

High

1367543

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1430094

RGAP1
Rac GTPase-activating protein 1

1

0

Small-scale

0.458

High

1437232

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1437678

PKHA5
Pleckstrin homology domain-containing family A member 5

1

0

Small-scale

0.458

High

1447550

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

Small-scale

0.458

High

1454769

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

1458844

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

1460770

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.458

High

1460771

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

1214499

Q5T8C6
Cell division cycle 16

1

10

High-throughput

0.445

High

1385647

DCPS
m7GpppX diphosphatase

1

0

Small-scale

0.426

High

351294

TTLL1
Polyglutamylase complex subunit TTLL1

3

0

High-throughput

0.347

High

377088

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

0

High-throughput

0.347

High

1435267

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

1244449

CP087
UPF0547 protein C16orf87

3

0

High-throughput

0.345

High

1339407

GP156
Probable G-protein coupled receptor 156

3

0

High-throughput

0.345

High

505113

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

1180549

FHOD3
FH1/FH2 domain-containing protein 3

1

0

High-throughput

0.279

Low

1206200

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1357442

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.279

Low

1454470

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

1460769

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.279

Low

49947

LNP1
Leukemia NUP98 fusion partner 1

1

0

Small-scale

0.249

Low

1225984

F91A1
Protein FAM91A1

1

0

Small-scale

0.249

Low

1256020

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1460772

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

Small-scale

0.249

Low

1238302

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025