Protein: TCAF1
TRPM8 channel-associated factor 1 (TRP channel-associated factor 1)

Gene: TCAF1
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q9Y4C2

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0030336 - negative regulation of cell migration
GO:0044325 - transmembrane transporter binding
GO:0090314 - positive regulation of protein targeting to membrane
GO:1901529 - positive regulation of anion channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1461231

IKZF3
Zinc finger protein Aiolos

5

4

High-throughput

0.657

High

508887

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

1

High-throughput

0.651

High

1046444

UBXN1
UBX domain-containing protein 1

3

1

High-throughput

0.609

High

1380314

CNKR1
Connector enhancer of kinase suppressor of ras 1

2

1

High-throughput

0.606

High

1151694

TRIP6
Thyroid receptor-interacting protein 6

2

0

High-throughput

0.606

High

1460666

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

4

High-throughput

0.604

High

355116

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

0

High-throughput

0.576

High

377299

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

2

0

High-throughput

0.576

High

1446831

GPC5C
G-protein coupled receptor family C group 5 member C

2

0

High-throughput

0.576

High

1277455

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.560

High

913913

ZN143
Zinc finger protein 143

2

1

High-throughput

0.553

High

950734

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

1090991

TRAF2
TNF receptor-associated factor 2

2

1

High-throughput

0.553

High

1307478

KRA13
Keratin-associated protein 1-3

2

1

High-throughput

0.553

High

1311489

TRI42
Tripartite motif-containing protein 42

2

3

High-throughput

0.553

High

1419274

TRI54
Tripartite motif-containing protein 54

2

3

High-throughput

0.553

High

1429062

PRD14
PR domain zinc finger protein 14

2

4

High-throughput

0.553

High

1432151

IKZF4
Zinc finger protein Eos

2

2

High-throughput

0.553

High

1447537

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

3

High-throughput

0.553

High

1452843

RBAK
RB-associated KRAB zinc finger protein

2

1

High-throughput

0.553

High

221202

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.549

High

401756

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.547

High

182851

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

171949

ZN263
Zinc finger protein 263

1

1

High-throughput

0.523

High

600399

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.523

High

987508

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

1060941

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.513

High

1341070

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.513

High

289377

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.489

High

1006324

CTG1B
Cancer/testis antigen 1

1

2

High-throughput

0.489

High

1129289

LAGE3
EKC/KEOPS complex subunit LAGE3

1

2

High-throughput

0.489

High

412868

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

1434321

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1459898

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

1491384

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

1

High-throughput

0.479

High

517143

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.470

High

538166

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

791870

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

927185

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

1024959

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1114740

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1249360

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1047788

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.445

High

1338616

ZN397
Zinc finger protein 397

1

2

High-throughput

0.445

High

1351547

HAVR2
Hepatitis A virus cellular receptor 2

1

1

High-throughput

0.445

High

1256239

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

844903

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

906375

GPC3
Glypican-3

1

0

High-throughput

0.426

High

1209836

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1273836

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

1310988

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.426

High

1452340

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.426

High

653748

PROZ
Vitamin K-dependent protein Z

1

1

High-throughput

0.407

High

1380373

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

3

High-throughput

0.407

High

1387716

VWCE
von Willebrand factor C and EGF domain-containing protein

1

2

High-throughput

0.407

High

1148581

SF3B4
Splicing factor 3B subunit 4

5

0

High-throughput

0.378

High

587541

TFE2
Transcription factor E2-alpha

3

0

High-throughput

0.352

High

1458260

TFP11
Tuftelin-interacting protein 11

3

0

High-throughput

0.352

High

1161278

MK06
Mitogen-activated protein kinase 6

3

0

High-throughput

0.345

High

659714

NFYA
Nuclear transcription factor Y subunit alpha

3

0

High-throughput

0.341

High

590119

RFA2
Replication protein A 32 kDa subunit

3

0

High-throughput

0.339

High

1350538

ZN398
Zinc finger protein 398

3

0

High-throughput

0.339

High

1112354

PWP1
Periodic tryptophan protein 1 homolog

2

0

High-throughput

0.328

High

1286757

CLC14
C-type lectin domain family 14 member A

2

0

High-throughput

0.328

High

1332165

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.328

High

1287232

PEG10
Retrotransposon-derived protein PEG10

2

0

Small-scale

0.318

High

70544

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1107510

BIRC2
Baculoviral IAP repeat-containing protein 2

2

0

High-throughput

0.316

High

1198058

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.316

High

1291019

TAXB1
Tax1-binding protein 1

2

0

High-throughput

0.316

High

1316318

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

2

0

High-throughput

0.316

High

1340392

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1448592

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.316

High

1462766

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

0

High-throughput

0.316

High

1491386

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

0

High-throughput

0.316

High

259189

DNJA2
DnaJ homolog subfamily A member 2

2

0

High-throughput

0.313

High

1389322

T3HPD
Trans-3-hydroxy-L-proline dehydratase

2

0

High-throughput

0.313

High

1447248

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.313

High

1365477

ZN592
Zinc finger protein 592

1

0

High-throughput

0.299

High

351621

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

0

High-throughput

0.282

High

800189

COIL
Coilin

1

0

High-throughput

0.282

High

337425

TGDS
dTDP-D-glucose 4,6-dehydratase

1

0

High-throughput

0.279

Low

387158

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.279

Low

1041808

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.279

Low

1232777

CPIN1
Anamorsin

1

0

High-throughput

0.279

Low

1272447

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low

1359402

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.279

Low

1371389

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.279

Low

1398214

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1429895

TOLIP
Toll-interacting protein

1

0

High-throughput

0.279

Low

1430009

SHRPN
Sharpin

1

0

High-throughput

0.279

Low

1430179

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

1460697

DDX41
Probable ATP-dependent RNA helicase DDX41

1

0

High-throughput

0.279

Low

1490932

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

0

High-throughput

0.279

Low

1186819

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

663

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

159932

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.249

Low

243386

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

294578

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

325192

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

335943

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.249

Low

414909

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

600482

ZNF28
Zinc finger protein 28

1

0

High-throughput

0.249

Low

755041

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.249

Low

769602

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831703

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1138810

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

1277024

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1280632

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.249

Low

1327292

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1360852

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1370495

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.249

Low

1383290

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1397595

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1414991

CP250
Centrosome-associated protein CEP250

1

0

High-throughput

0.249

Low

1432735

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.249

Low

1435493

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1438957

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1451337

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1459436

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1460330

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1491029

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1156099

ZNF79
Zinc finger protein 79

1

0

High-throughput

0.232

Low

1185879

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1358920

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

High-throughput

0.232

Low

1384581

RNF25
E3 ubiquitin-protein ligase RNF25

1

0

High-throughput

0.232

Low

1390929

LRC46
Leucine-rich repeat-containing protein 46

1

0

High-throughput

0.232

Low

1391884

AURKB
Aurora kinase B

1

0

High-throughput

0.232

Low

1402857

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.232

Low

1412061

WDR83
WD repeat domain-containing protein 83

1

0

High-throughput

0.232

Low

1451230

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1491385

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025