Protein: PELP1
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)

Gene: PELP1
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q8IZL8

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316580

WDR18
WD repeat-containing protein 18

11

14

Small-scale

0.981

High

1316586

SENP3
Sentrin-specific protease 3

7

4

Small-scale

0.751

High

1316595

TEX10
Testis-expressed protein 10

6

1

Small-scale

0.730

High

1316606

LAS1L
Ribosomal biogenesis protein LAS1L

5

2

Small-scale

0.713

High

1211315

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

4

1

Small-scale

0.694

High

992850

RACK1
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.691

High

447209

NPM
Nucleophosmin

4

2

Small-scale

0.691

High

396481

ESR1
Estrogen receptor

4

20

Small-scale

0.686

High

964362

SUMO2
Small ubiquitin-related modifier 2

4

7

Small-scale

0.683

High

998530

H31
Histone H3.1

3

20

Small-scale

0.678

High

1017012

H33
Histone H3.3

2

20

Small-scale

0.633

High

414187

P53
Cellular tumor antigen p53

2

18

Small-scale

0.629

High

288698

NPM3
Nucleoplasmin-3

2

2

High-throughput

0.628

High

1316555

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

High-throughput

0.618

High

1316560

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1316570

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.618

High

134085

IPO5
Importin-5

2

6

Small-scale

0.611

High

419078

H2A1B
Histone H2A type 1-B/E

2

14

High-throughput

0.611

High

586778

RS2
Small ribosomal subunit protein uS5

2

1

High-throughput

0.611

High

686267

RL13
Large ribosomal subunit protein eL13

2

1

High-throughput

0.611

High

693839

RL10
Large ribosomal subunit protein uL16

2

1

High-throughput

0.611

High

1161533

IF16
Gamma-interferon-inducible protein 16

2

7

High-throughput

0.611

High

1235466

IFIX
Pyrin and HIN domain-containing protein 1

2

7

High-throughput

0.611

High

246750

KDM1A
Lysine-specific histone demethylase 1A

1

13

Small-scale

0.597

High

557379

SRC
Proto-oncogene tyrosine-protein kinase Src

2

19

Small-scale

0.595

High

979967

H4
Histone H4

2

10

Small-scale

0.595

High

589128

RFA2
Replication protein A 32 kDa subunit

2

7

High-throughput

0.584

High

695912

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

High-throughput

0.584

High

768621

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

1067497

EP300
Histone acetyltransferase p300

2

18

Small-scale

0.584

High

1316592

ANLN
Anillin

2

4

High-throughput

0.584

High

626284

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

15

High-throughput

0.578

High

827841

STAT3
Signal transducer and activator of transcription 3

1

11

Small-scale

0.573

High

442764

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.561

High

1316589

BCAS3
BCAS3 microtubule associated cell migration factor

1

1

Small-scale

0.561

High

1316574

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

8

High-throughput

0.549

High

290254

TM1L1
TOM1-like protein 1

1

1

High-throughput

0.541

High

856791

BAG6
Large proline-rich protein BAG6

1

14

High-throughput

0.541

High

317416

KPCD3
Serine/threonine-protein kinase D3

1

7

High-throughput

0.536

High

338899

CBX6
Chromobox protein homolog 6

1

15

High-throughput

0.536

High

428859

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.536

High

502428

H2A1
Histone H2A type 1

1

14

High-throughput

0.536

High

504841

H2AB1
Histone H2A-Bbd type 1

1

17

High-throughput

0.536

High

624093

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

12

High-throughput

0.536

High

625484

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

833140

MNDA
Myeloid cell nuclear differentiation antigen

1

7

High-throughput

0.536

High

849205

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.536

High

859353

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

872518

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

897052

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

1006538

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.536

High

1100888

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.536

High

1213568

PHF19
PHD finger protein 19

1

7

High-throughput

0.536

High

1316575

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.536

High

1316579

RBM4B
RNA-binding protein 4B

1

7

High-throughput

0.536

High

1316591

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.536

High

1316600

SRP68
Signal recognition particle subunit SRP68

1

2

High-throughput

0.536

High

1316603

SRPK3
SRSF protein kinase 3

1

15

High-throughput

0.536

High

1316607

NGN3
Neurogenin-3

1

11

High-throughput

0.536

High

1316594

MDN1
Midasin

1

11

Small-scale

0.534

High

169649

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.523

High

884159

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

1260371

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.513

High

1281415

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1316572

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

181907

SMAD9
Mothers against decapentaplegic homolog 9

1

13

High-throughput

0.508

High

951751

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

1037262

H11
Histone H1.1

1

6

Small-scale

0.501

High

1162829

H2A2C
Histone H2A type 2-C

1

14

Small-scale

0.501

High

1163050

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.501

High

1316567

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

High-throughput

0.501

High

389439

FINC
Fibronectin

1

5

High-throughput

0.489

High

1316583

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.489

High

1316563

ESR2
Estrogen receptor beta

1

20

High-throughput

0.484

High

129247

MEN1
Menin

1

4

High-throughput

0.479

High

129768

CBX4
E3 SUMO-protein ligase CBX4

1

15

Small-scale

0.479

High

155119

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.479

High

157598

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

188932

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

190990

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

260169

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

272315

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

319897

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

331136

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

341620

EYA4
Protein phosphatase EYA4

1

16

High-throughput

0.479

High

342953

HERC2
E3 ubiquitin-protein ligase HERC2

1

9

High-throughput

0.479

High

352488

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

372541

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

404212

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

430121

JUN
Transcription factor Jun

1

20

High-throughput

0.479

High

459311

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

504924

H2AB2
Histone H2A-Bbd type 2/3

1

17

High-throughput

0.479

High

520197

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

537492

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

591727

H2AX
Histone H2AX

1

14

High-throughput

0.479

High

652539

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.479

High

714261

PML
Protein PML

1

15

High-throughput

0.479

High

731451

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

755978

MCM5
DNA replication licensing factor MCM5

1

6

High-throughput

0.479

High

810213

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

831045

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

854887

RECQ1
ATP-dependent DNA helicase Q1

1

16

High-throughput

0.479

High

907495

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

923362

MK12
Mitogen-activated protein kinase 12

1

11

Small-scale

0.479

High

927405

ATX1
Ataxin-1

1

3

High-throughput

0.479

High

960168

RL26
Large ribosomal subunit protein uL24

1

1

Small-scale

0.479

High

967318

TSN5
Tetraspanin-5

1

3

Small-scale

0.479

High

970758

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

979056

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

1004808

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1033064

EWS
RNA-binding protein EWS

1

12

High-throughput

0.479

High

1035767

KIF23
Kinesin-like protein KIF23

1

7

High-throughput

0.479

High

1045500

TF65
Transcription factor p65

1

16

High-throughput

0.479

High

1088441

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

7

High-throughput

0.479

High

1107011

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1132215

CBX2
Chromobox protein homolog 2

1

15

Small-scale

0.479

High

1134980

CUL7
Cullin-7

1

5

High-throughput

0.479

High

1138386

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1146248

ZMY11
Zinc finger MYND domain-containing protein 11

1

15

Small-scale

0.479

High

1155531

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.479

High

1254584

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1312457

PHC2
Polyhomeotic-like protein 2

1

8

Small-scale

0.479

High

1313253

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1316557

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.479

High

1316558

SIR6
NAD-dependent protein deacylase sirtuin-6

1

11

High-throughput

0.479

High

1316559

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1316561

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1316564

HDAC2
Histone deacetylase 2

1

15

Small-scale

0.479

High

1316565

CBP
CREB-binding protein

1

18

Small-scale

0.479

High

1316566

KAT6A
Histone acetyltransferase KAT6A

1

19

High-throughput

0.479

High

1316568

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.479

High

1316576

NELL2
Protein kinase C-binding protein NELL2

1

3

Small-scale

0.479

High

1316577

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1316578

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

2

High-throughput

0.479

High

1316582

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

1316584

FOXQ1
Forkhead box protein Q1

1

13

High-throughput

0.479

High

1316587

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

15

High-throughput

0.479

High

1316588

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

1316590

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

1316593

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.479

High

1316599

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

1316604

CHTOP
Chromatin target of PRMT1 protein

1

1

Small-scale

0.479

High

1316605

TRAF6
TNF receptor-associated factor 6

1

12

Small-scale

0.479

High

560447

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

1128775

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1159308

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.458

High

1161022

FSCN1
Fascin

1

0

High-throughput

0.458

High

1316571

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1316573

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1316598

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

965083

WDR5
WD repeat-containing protein 5

1

11

Small-scale

0.445

High

1111102

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1130336

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

6

High-throughput

0.445

High

1316596

S39A1
Zinc transporter ZIP1

1

1

High-throughput

0.445

High

1316601

AGO1
Protein argonaute-1

1

1

High-throughput

0.445

High

1219846

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.438

High

412240

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

897149

TNF10
Tumor necrosis factor ligand superfamily member 10

1

4

Small-scale

0.437

High

1126122

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1286827

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.437

High

1316556

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1316562

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

1316569

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1316581

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.437

High

1316585

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

Small-scale

0.437

High

1316597

TMOD3
Tropomodulin-3

1

2

Small-scale

0.437

High

1316602

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

516554

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

791522

SYUA
Alpha-synuclein

1

1

Small-scale

0.408

High

1127427

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1008478

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

Small-scale

0.251

Low

404607

TFF1
Trefoil factor 1

1

0

Small-scale

0.249

Low

1092419

IL24
Interleukin-24

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025