Protein: MPIP2
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)

Gene: MPIP2, CDC25B
Organism: Homo sapiens
Interactions: 120
UniProt ID: P30305

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000922 - spindle pole
GO:0001556 - oocyte maturation
GO:0004721 - phosphoprotein phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414768

CDK1
Cyclin-dependent kinase 1

4

18

Small-scale

0.873

High

625159

CDK2
Cyclin-dependent kinase 2

3

18

Small-scale

0.828

High

673479

MELK
Maternal embryonic leucine zipper kinase

2

1

Small-scale

0.806

High

673469

CDK5
Cyclin-dependent kinase 5

2

18

Small-scale

0.768

High

673533

FBW1B
F-box/WD repeat-containing protein 11

14

7

Small-scale

0.762

High

673539

FBW1A
F-box/WD repeat-containing protein 1A

11

7

Small-scale

0.758

High

673452

1433B
14-3-3 protein beta/alpha

11

20

Small-scale

0.758

High

673464

1433Z
14-3-3 protein zeta/delta

10

20

Small-scale

0.758

High

673463

1433E
14-3-3 protein epsilon

9

9

Small-scale

0.752

High

673471

1433F
14-3-3 protein eta

7

20

Small-scale

0.749

High

154137

CHK1
Serine/threonine-protein kinase Chk1

1

3

Small-scale

0.747

High

673466

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.747

High

673462

1433G
14-3-3 protein gamma

6

20

Small-scale

0.730

High

646656

1433T
14-3-3 protein theta

5

20

Small-scale

0.721

High

673483

MK14
Mitogen-activated protein kinase 14

1

12

Small-scale

0.692

High

673455

MK09
Mitogen-activated protein kinase 9

1

11

Small-scale

0.647

High

673456

MAPK2
MAP kinase-activated protein kinase 2

1

2

Small-scale

0.647

High

673497

BRSK2
Serine/threonine-protein kinase BRSK2

1

2

Small-scale

0.647

High

673453

1433S
14-3-3 protein sigma

3

20

Small-scale

0.633

High

673461

PSME3
Proteasome activator complex subunit 3

3

0

High-throughput

0.625

High

166537

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.618

High

230844

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

1

High-throughput

0.618

High

373754

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

Small-scale

0.618

High

673450

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.618

High

673468

CDK3
Cyclin-dependent kinase 3

1

18

High-throughput

0.618

High

673470

CDK16
Cyclin-dependent kinase 16

1

18

High-throughput

0.618

High

673501

TBC15
TBC1 domain family member 15

1

1

High-throughput

0.618

High

673529

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

High-throughput

0.586

High

538481

CCNB1
G2/mitotic-specific cyclin-B1

2

9

Small-scale

0.584

High

369058

ESR1
Estrogen receptor

1

2

Small-scale

0.573

High

673536

CC14A
Dual specificity protein phosphatase CDC14A

1

3

Small-scale

0.561

High

673516

ANM1
Protein arginine N-methyltransferase 1

2

0

High-throughput

0.559

High

673484

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.553

High

673522

WDR6
tRNA

1

9

High-throughput

0.536

High

673467

KRT85
Keratin, type II cuticular Hb5

1

1

High-throughput

0.515

High

673472

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.515

High

673482

K1H1
Keratin, type I cuticular Ha1

1

2

High-throughput

0.515

High

673507

KRT35
Keratin, type I cuticular Ha5

1

2

High-throughput

0.515

High

422489

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.513

High

448555

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

618534

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.513

High

673457

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.513

High

673476

MTMR3
Myotubularin-related protein 3

1

0

High-throughput

0.513

High

673514

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

414447

PRGR
Progesterone receptor

1

2

Small-scale

0.501

High

487164

ANDR
Androgen receptor

1

2

Small-scale

0.501

High

673492

LMTK1
Serine/threonine-protein kinase LMTK1

1

1

High-throughput

0.494

High

673515

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

673508

KAT2B
Histone acetyltransferase KAT2B

1

0

Small-scale

0.480

High

162430

XPO1
Exportin-1

1

4

High-throughput

0.479

High

196403

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

207895

XPOT
Exportin-T

1

3

High-throughput

0.479

High

237170

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

253319

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

264273

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

316233

NADK
NAD kinase

1

1

High-throughput

0.479

High

349147

RASH
GTPase HRas

1

1

Small-scale

0.479

High

590132

CCNA2
Cyclin-A2

1

8

Small-scale

0.479

High

598430

NF1
Neurofibromin

1

3

High-throughput

0.479

High

673454

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.479

High

673458

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

673459

AFAD
Afadin

1

4

High-throughput

0.479

High

673460

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

673465

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

673473

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

673474

CDC20
Cell division cycle protein 20 homolog

1

2

High-throughput

0.479

High

673475

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

673477

CUL1
Cullin-1

1

3

High-throughput

0.479

High

673478

FHL1
Four and a half LIM domains protein 1

1

5

Small-scale

0.479

High

673480

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

673485

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.479

High

673486

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.479

High

673488

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

673491

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.479

High

673494

PHLB2
Pleckstrin homology-like domain family B member 2

1

3

High-throughput

0.479

High

673495

KSR1
Kinase suppressor of Ras 1

1

4

High-throughput

0.479

High

673500

NAV1
Neuron navigator 1

1

1

High-throughput

0.479

High

673502

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

673503

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.479

High

673505

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

673512

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

2

High-throughput

0.479

High

673513

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.479

High

673517

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

673518

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

673519

RTKN
Rhotekin

1

1

High-throughput

0.479

High

673521

PKHA5
Pleckstrin homology domain-containing family A member 5

1

6

High-throughput

0.479

High

673523

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

673530

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.479

High

673531

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.479

High

673532

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

673534

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

673535

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

673538

GAB2
GRB2-associated-binding protein 2

1

6

High-throughput

0.479

High

673540

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

47920

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.458

High

673451

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.458

High

673487

IER5
Immediate early response gene 5 protein

1

0

Small-scale

0.458

High

673506

DOCK2
Dedicator of cytokinesis protein 2

1

0

High-throughput

0.458

High

673510

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

673511

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

673520

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

673524

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.458

High

673525

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

673526

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

673537

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.458

High

216182

CALU
Calumenin

1

1

High-throughput

0.437

High

216905

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

673481

RCN1
Reticulocalbin-1

1

1

High-throughput

0.437

High

673490

AN34A
Ankyrin repeat domain-containing protein 34A

1

2

High-throughput

0.437

High

673493

SYDE1
Rho GTPase-activating protein SYDE1

1

4

High-throughput

0.437

High

673496

CC28A
Coiled-coil domain-containing protein 28A

1

1

High-throughput

0.437

High

673498

DJC10
DnaJ homolog subfamily C member 10

1

2

High-throughput

0.437

High

673504

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.437

High

673509

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

Small-scale

0.437

High

673527

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.437

High

673528

CING
Cingulin

1

1

High-throughput

0.437

High

673541

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

673489

Q68DS0
Uncharacterized protein DKFZp781N011

1

7

High-throughput

0.407

High

673499

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024