Protein: SRS2
ATP-dependent DNA helicase SRS2 (EC 5.6.2.4) (DNA 3'-5' helicase SRS2)

Gene: SRS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 158
UniProt ID: P12954

Gene Ontology (top 5):
GO:0000725 - recombinational repair
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523333

PCNA
Proliferating cell nuclear antigen

9

1

Small-scale

0.759

High

523346

RAD51
DNA repair protein RAD51

12

4

Small-scale

0.758

High

523463

SMT3
Ubiquitin-like protein SMT3

7

2

Small-scale

0.752

High

419591

RAD52
DNA repair and recombination protein RAD52

3

1

Small-scale

0.655

High

523420

UBC9
SUMO-conjugating enzyme UBC9

2

3

Small-scale

0.622

High

523439

SIZ1
E3 SUMO-protein ligase SIZ1

2

3

Small-scale

0.614

High

523460

SIZ2
E3 SUMO-protein ligase SIZ2

2

3

Small-scale

0.614

High

523361

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.606

High

523345

RAD57
DNA repair protein RAD57

2

3

Small-scale

0.595

High

523382

RAD55
DNA repair protein RAD55

2

0

Small-scale

0.591

High

500600

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

2

1

Small-scale

0.584

High

523407

GLDS1
Protein GDS1

2

0

Small-scale

0.570

High

523360

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

2

0

Small-scale

0.569

High

339392

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.561

High

523390

EXO1
Exodeoxyribonuclease 1

1

5

Small-scale

0.561

High

523452

BRE1
E3 ubiquitin-protein ligase BRE1

1

3

Small-scale

0.561

High

523417

DPOD3
DNA polymerase delta subunit 3

2

0

Small-scale

0.559

High

523366

SGS1
ATP-dependent helicase SGS1

1

4

Small-scale

0.552

High

523456

ULS1
ATP-dependent helicase ULS1

1

2

Small-scale

0.552

High

523446

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.549

High

510079

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

523461

RAD59
DNA repair protein RAD59

1

1

Small-scale

0.527

High

523352

PYC2
Pyruvate carboxylase 2

1

1

High-throughput

0.515

High

426354

PMM
Phosphomannomutase

1

0

High-throughput

0.513

High

523385

DUN1
DNA damage response protein kinase DUN1

1

0

High-throughput

0.513

High

523403

MSL1
U2 small nuclear ribonucleoprotein B''

1

4

High-throughput

0.508

High

523438

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.504

High

523448

ESC2
Protein ESC2

1

0

Small-scale

0.504

High

523363

RAD54
DNA repair and recombination protein RAD54

1

2

Small-scale

0.501

High

381676

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

1

High-throughput

0.500

High

397569

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.500

High

485436

SSBP1
Single-stranded nucleic acid-binding protein

1

6

High-throughput

0.500

High

523336

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.500

High

523338

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

523431

ACT
Actin

1

1

High-throughput

0.500

High

523340

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.493

High

523412

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.493

High

523383

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

High-throughput

0.486

High

425537

RAD2
DNA repair protein RAD2

1

3

Small-scale

0.481

High

523354

KNS1
Dual specificity protein kinase KNS1

1

1

Small-scale

0.481

High

523362

RAD5
DNA repair protein RAD5

1

3

Small-scale

0.481

High

523378

ECM29
Proteasome component ECM29

1

3

Small-scale

0.481

High

523387

IFH1
Protein IFH1

1

1

Small-scale

0.481

High

523399

ULP2
Ubiquitin-like-specific protease 2

1

2

Small-scale

0.481

High

523400

PDR11
ATP-dependent permease PDR11

1

1

Small-scale

0.481

High

523401

MPH1
ATP-dependent DNA helicase MPH1

1

3

Small-scale

0.481

High

523414

NMD5
Nonsense-mediated mRNA decay protein 5

1

2

Small-scale

0.481

High

523416

IKS1
Probable serine/threonine-protein kinase IKS1

1

2

Small-scale

0.481

High

523418

JHD2
Histone demethylase JHD2

1

1

Small-scale

0.481

High

523421

IMB5
Importin subunit beta-5

1

1

Small-scale

0.481

High

523425

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

3

Small-scale

0.481

High

523427

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

Small-scale

0.481

High

523432

SEN1
Helicase SEN1

1

2

Small-scale

0.481

High

523450

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

Small-scale

0.481

High

523454

MLH2
DNA mismatch repair protein MLH2

1

1

Small-scale

0.481

High

523455

SMC5
Structural maintenance of chromosomes protein 5

1

3

Small-scale

0.481

High

523470

MTR10
mRNA transport regulator MTR10

1

2

Small-scale

0.481

High

343512

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.479

High

378264

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.479

High

523335

HXKG
Glucokinase-1

1

0

High-throughput

0.479

High

424979

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.479

High

523349

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

523388

DHE5
NADP-specific glutamate dehydrogenase 2

1

1

High-throughput

0.479

High

523433

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.479

High

523437

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

523424

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.470

High

523449

CORO
Coronin-like protein

1

4

High-throughput

0.470

High

420075

TOP2
DNA topoisomerase 2

1

0

Small-scale

0.460

High

523339

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

Small-scale

0.460

High

523341

KIN3
Serine/threonine-protein kinase KIN3

1

0

Small-scale

0.460

High

523343

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.460

High

523344

NAP1
Nucleosome assembly protein

1

0

Small-scale

0.460

High

523348

RAD14
DNA repair protein RAD14

1

0

Small-scale

0.460

High

523351

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.460

High

523353

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

Small-scale

0.460

High

523356

MEI5
Meiosis protein 5

1

0

Small-scale

0.460

High

523359

TOA1
Transcription initiation factor IIA large subunit

1

0

Small-scale

0.460

High

523377

KSP1
Serine/threonine-protein kinase KSP1

1

0

Small-scale

0.460

High

523379

ORC6
Origin recognition complex subunit 6

1

0

Small-scale

0.460

High

523381

YH02
Uncharacterized protein YHR202W

1

0

Small-scale

0.460

High

523384

SMC2
Structural maintenance of chromosomes protein 2

1

0

Small-scale

0.460

High

523391

SAP1
Protein SAP1

1

0

Small-scale

0.460

High

523404

MTA70
N6-adenosine-methyltransferase IME4

1

0

Small-scale

0.460

High

523413

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.460

High

523423

YGK1
5'-deoxynucleotidase YGK1

1

0

Small-scale

0.460

High

523429

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

523444

FAR8
Factor arrest protein 8

1

0

Small-scale

0.460

High

523445

DUS3
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]

1

0

Small-scale

0.460

High

523447

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.460

High

523451

ELP1
Elongator complex protein 1

1

0

Small-scale

0.460

High

523465

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.460

High

523466

NDJ1
Non-disjunction protein 1

1

0

Small-scale

0.460

High

523467

RLF2
Chromatin assembly factor 1 subunit p90

1

0

Small-scale

0.460

High

472538

YD14B
Transposon Ty1-DR5 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

501276

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.458

High

523355

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

523372

SPO14
Phospholipase D1

1

0

High-throughput

0.458

High

523376

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.458

High

523386

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.458

High

523405

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

523406

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

523426

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.458

High

523430

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.458

High

523442

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.458

High

452942

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

490168

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

493055

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

523334

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

523350

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

523357

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

523368

LHS1
Heat shock protein 70 homolog LHS1

1

8

High-throughput

0.445

High

523402

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.445

High

523410

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.445

High

333678

ADH1
Alcohol dehydrogenase 1

1

2

Small-scale

0.439

High

523337

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.439

High

523409

EGT2
Protein EGT2

1

1

Small-scale

0.439

High

523435

ESC1
Silent chromatin protein ESC1

1

3

Small-scale

0.439

High

523436

WDR59
Maintenance of telomere capping protein 5

1

4

Small-scale

0.439

High

523380

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.437

High

523440

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.437

High

523443

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.437

High

523453

WHI4
Protein WHI4

1

2

High-throughput

0.437

High

523428

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

523464

HSP42
Heat shock protein 42

2

0

High-throughput

0.307

High

523469

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

523332

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.279

Low

523358

FIMB
Fimbrin

1

0

High-throughput

0.269

Low

523365

KTR2
Probable mannosyltransferase KTR2

1

0

Small-scale

0.251

Low

523367

NU120
Nucleoporin NUP120

1

0

Small-scale

0.251

Low

523370

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

Small-scale

0.251

Low

523371

BCH2
Protein BCH2

1

0

Small-scale

0.251

Low

523374

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

Small-scale

0.251

Low

523375

FZO1
Mitofusin FZO1

1

0

Small-scale

0.251

Low

523389

HPH2
Protein HPH2

1

0

Small-scale

0.251

Low

523392

PPOX
Protoporphyrinogen oxidase

1

0

Small-scale

0.251

Low

523393

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

523394

COX15
Heme A synthase COX15

1

0

Small-scale

0.251

Low

523395

GAT2
Protein GAT2

1

0

Small-scale

0.251

Low

523397

YIQ1
Uncharacterized protein YIL161W

1

0

Small-scale

0.251

Low

523408

SSU1
Sulfite efflux pump SSU1

1

0

Small-scale

0.251

Low

523415

ASG7
Protein ASG7

1

0

Small-scale

0.251

Low

523419

BNS1
Protein BNS1

1

0

Small-scale

0.251

Low

523434

HEH2
Inner nuclear membrane protein HEH2

1

0

Small-scale

0.251

Low

523441

GLU2B
Glucosidase 2 subunit beta

1

0

Small-scale

0.251

Low

523457

PLP2
Phosducin-like protein 2

1

0

Small-scale

0.251

Low

523459

SIA1
Protein SIA1

1

0

Small-scale

0.251

Low

523462

UBX3
UBX domain-containing protein 3

1

0

Small-scale

0.251

Low

523468

TAR1
Protein TAR1

1

0

Small-scale

0.251

Low

523342

MAN1
Alpha-mannosidase

1

0

High-throughput

0.249

Low

523347

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.249

Low

523364

SFC1
Succinate/fumarate mitochondrial transporter

1

0

High-throughput

0.249

Low

523373

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.249

Low

523396

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.249

Low

523398

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.249

Low

523411

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.249

Low

523422

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.249

Low

523458

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low

523369

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024