Protein: MARH4
E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4)

Gene: MARH4, MARCHF4
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9P2E8

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004842 - ubiquitin-protein transferase activity
GO:0005795 - Golgi stack
GO:0005802 - trans-Golgi network
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1436055

DJC18
DnaJ homolog subfamily C member 18

2

4

High-throughput

0.558

High

180087

BET1
BET1 homolog

1

6

High-throughput

0.536

High

246317

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

11

High-throughput

0.536

High

294798

CAN15
Calpain-15

1

1

High-throughput

0.536

High

1276351

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.536

High

1317125

ABCA7
Phospholipid-transporting ATPase ABCA7

1

4

High-throughput

0.536

High

1446649

AT132
Polyamine-transporting ATPase 13A2

1

4

High-throughput

0.536

High

1448881

RAB6B
Ras-related protein Rab-6B

1

3

High-throughput

0.536

High

1454536

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

2

High-throughput

0.536

High

258348

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.513

High

1085480

SRBP2
Sterol regulatory element-binding protein 2

1

0

High-throughput

0.513

High

508754

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.501

High

906806

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

19

Small-scale

0.501

High

971221

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

Small-scale

0.501

High

161162

ABCD4
Lysosomal cobalamin transporter ABCD4

1

6

High-throughput

0.489

High

297076

DHRS3
Short-chain dehydrogenase/reductase 3

1

2

High-throughput

0.489

High

614739

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

7

High-throughput

0.489

High

787262

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.489

High

790182

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

1

High-throughput

0.489

High

1043241

TAP2
Antigen peptide transporter 2

1

3

High-throughput

0.489

High

1116848

AVR2B
Activin receptor type-2B

1

6

High-throughput

0.489

High

1127865

ERG1
Squalene monooxygenase

1

1

High-throughput

0.489

High

1195398

ANO6
Anoctamin-6

1

1

High-throughput

0.489

High

1212504

MRP7
ATP-binding cassette sub-family C member 10

1

2

High-throughput

0.489

High

1238383

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.489

High

1248258

KCNT2
Potassium channel subfamily T member 2

1

1

High-throughput

0.489

High

1260352

ANO5
Anoctamin-5

1

1

High-throughput

0.489

High

1278330

LRP10
Low-density lipoprotein receptor-related protein 10

1

3

High-throughput

0.489

High

1294516

VRK2
Serine/threonine-protein kinase VRK2

1

2

High-throughput

0.489

High

1329685

AN13C
Ankyrin repeat domain-containing protein 13C

1

2

High-throughput

0.489

High

1351788

ST7L
Suppressor of tumorigenicity 7 protein-like

1

1

High-throughput

0.489

High

1352389

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.489

High

1372410

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.489

High

1407225

ABCA3
Phospholipid-transporting ATPase ABCA3

1

3

High-throughput

0.489

High

1416697

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.489

High

1419576

ABCA2
ATP-binding cassette sub-family A member 2

1

2

High-throughput

0.489

High

1434877

PCX3
Pecanex-like protein 3

1

2

High-throughput

0.489

High

1445988

ABCB9
ABC-type oligopeptide transporter ABCB9

1

3

High-throughput

0.489

High

1448165

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

1454526

NB5R1
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.489

High

1454527

S12A6
Solute carrier family 12 member 6

1

4

High-throughput

0.489

High

1454530

S12A4
Solute carrier family 12 member 4

1

4

High-throughput

0.489

High

1454532

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.489

High

1454533

LRP12
Low-density lipoprotein receptor-related protein 12

1

3

High-throughput

0.489

High

1454534

SNX14
Sorting nexin-14

1

1

High-throughput

0.489

High

1454535

S12A7
Solute carrier family 12 member 7

1

4

High-throughput

0.489

High

445084

S10A9
Protein S100-A9

1

2

High-throughput

0.479

High

1364066

NICA
Nicastrin

1

1

High-throughput

0.479

High

1454529

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.479

High

156170

TRAD1
TRAF-type zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

912021

DGKE
Diacylglycerol kinase epsilon

1

0

High-throughput

0.458

High

1214922

WLS
Protein wntless homolog

1

0

High-throughput

0.458

High

1338491

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.458

High

347382

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.437

High

399744

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

2

High-throughput

0.437

High

416772

TYSY
Thymidylate synthase

1

2

High-throughput

0.437

High

535622

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.437

High

592910

CBR1
Carbonyl reductase [NADPH] 1

1

3

High-throughput

0.437

High

722760

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

1

High-throughput

0.437

High

1049861

1433F
14-3-3 protein eta

1

1

High-throughput

0.437

High

1207904

S27A3
Long-chain fatty acid transport protein 3

1

1

High-throughput

0.437

High

1218493

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.437

High

1293304

LSR
Lipolysis-stimulated lipoprotein receptor

1

2

High-throughput

0.437

High

1386226

ASTRA
Protein Aster-A

1

1

High-throughput

0.437

High

1405061

SORT
Sortilin

1

1

High-throughput

0.437

High

1420107

ULBP1
UL16-binding protein 1

1

1

Small-scale

0.437

High

1451538

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

1

High-throughput

0.437

High

1452162

DJB12
DnaJ homolog subfamily B member 12

1

2

High-throughput

0.437

High

1454531

DJC16
DnaJ homolog subfamily C member 16

1

3

High-throughput

0.437

High

295891

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.318

High

1103596

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

2

0

High-throughput

0.318

High

155515

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.279

Low

243834

ADCY3
Adenylate cyclase type 3

1

0

High-throughput

0.279

Low

261302

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

274924

LRP5
Low-density lipoprotein receptor-related protein 5

1

0

High-throughput

0.279

Low

450280

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

1010541

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1015146

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.279

Low

1085164

TMM94
Transmembrane protein 94

1

0

High-throughput

0.279

Low

1164179

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.279

Low

1212319

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

1214136

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1217666

MARC1
Mitochondrial amidoxime-reducing component 1

1

0

High-throughput

0.279

Low

1219681

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1231481

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1248685

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.279

Low

1279555

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.279

Low

1324317

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.279

Low

1358627

BT2A2
Butyrophilin subfamily 2 member A2

1

0

High-throughput

0.279

Low

1382788

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.279

Low

1384192

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

1385211

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1388353

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

1411077

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.279

Low

1414838

ABHD6
Monoacylglycerol lipase ABHD6

1

0

High-throughput

0.279

Low

1416273

CA043
Protein C1orf43

1

0

High-throughput

0.279

Low

1446232

NRN1
Neuritin

1

0

High-throughput

0.279

Low

1450252

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.279

Low

1454528

KCNG1
Voltage-gated potassium channel regulatory subunit KCNG1

1

0

High-throughput

0.279

Low

441516

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.249

Low

460889

CATB
Cathepsin B

1

0

High-throughput

0.249

Low

884798

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

934295

BI1
Bax inhibitor 1

1

0

High-throughput

0.249

Low

944346

TMM33
Transmembrane protein 33

1

0

High-throughput

0.249

Low

1143808

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.249

Low

1388113

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.249

Low

1395877

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.249

Low

1439370

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.249

Low

1439470

SEC12
Guanine nucleotide-exchange factor SEC12

1

0

High-throughput

0.249

Low

1211084

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025