Protein: SIGL1
SIGLEC family-like protein 1

Gene: SIGL1, SIGLECL1
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q8N7X8

Gene Ontology (top 5):
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334841

IPO7
Importin-7

3

7

High-throughput

0.662

High

1124208

EI2BA
Translation initiation factor eIF2B subunit alpha

3

2

High-throughput

0.662

High

1330735

IPO9
Importin-9

3

6

High-throughput

0.662

High

248913

GSDME
Gasdermin-E

3

0

High-throughput

0.634

High

828406

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.634

High

1330737

S29A1
Equilibrative nucleoside transporter 1

3

0

High-throughput

0.634

High

641210

FGFR2
Fibroblast growth factor receptor 2

2

1

High-throughput

0.628

High

761262

RYK
Tyrosine-protein kinase RYK

2

2

High-throughput

0.628

High

1088155

CNTN1
Contactin-1

2

1

High-throughput

0.628

High

1140563

KIF14
Kinesin-like protein KIF14

2

1

High-throughput

0.628

High

1221111

CD276
CD276 antigen

2

1

High-throughput

0.628

High

1325361

STAG2
Cohesin subunit SA-2

2

1

High-throughput

0.628

High

1330719

IPO4
Importin-4

2

6

High-throughput

0.628

High

1330765

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

2

3

High-throughput

0.628

High

189222

IPO8
Importin-8

3

6

High-throughput

0.604

High

251239

RNBP6
Ran-binding protein 6

3

5

High-throughput

0.604

High

273212

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

4

High-throughput

0.604

High

890142

EI2BB
Translation initiation factor eIF2B subunit beta

3

2

High-throughput

0.604

High

1095908

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

2

High-throughput

0.604

High

1277500

MON2
Protein MON2 homolog

3

3

High-throughput

0.604

High

1330724

TNPO1
Transportin-1

3

7

High-throughput

0.604

High

1330730

INT4
Integrator complex subunit 4

3

1

High-throughput

0.604

High

1330746

EI2BG
Translation initiation factor eIF2B subunit gamma

3

1

High-throughput

0.604

High

1330757

EI2BD
Translation initiation factor eIF2B subunit delta

3

2

High-throughput

0.604

High

1330758

IPO11
Importin-11

3

6

High-throughput

0.604

High

1330763

TNPO3
Transportin-3

3

7

High-throughput

0.604

High

71642

ELAP2
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2

2

0

High-throughput

0.602

High

637927

NF1
Neurofibromin

2

0

High-throughput

0.602

High

890856

TSC2
Tuberin

2

0

High-throughput

0.602

High

944520

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.602

High

945274

NU107
Nuclear pore complex protein Nup107

2

0

High-throughput

0.602

High

1224752

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.602

High

1273956

DYM
Dymeclin

2

0

High-throughput

0.602

High

1315097

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.602

High

1330727

GCP3
Gamma-tubulin complex component 3

2

0

High-throughput

0.602

High

1330731

CK5P3
CDK5 regulatory subunit-associated protein 3

2

0

High-throughput

0.602

High

1330733

COG8
Conserved oligomeric Golgi complex subunit 8

2

0

High-throughput

0.602

High

1330755

DDX20
Probable ATP-dependent RNA helicase DDX20

2

0

High-throughput

0.602

High

1330761

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.602

High

164607

TNPO2
Transportin-2

3

7

High-throughput

0.593

High

318149

IPO13
Importin-13

2

7

High-throughput

0.574

High

333495

MPZL1
Myelin protein zero-like protein 1

2

1

High-throughput

0.574

High

1201819

SDK2
Protein sidekick-2

2

1

High-throughput

0.574

High

1216517

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

2

2

High-throughput

0.574

High

1272089

MIGA2
Mitoguardin 2

2

1

High-throughput

0.574

High

1330713

MIGA1
Mitoguardin 1

2

1

High-throughput

0.574

High

1330721

STAG1
Cohesin subunit SA-1

2

1

High-throughput

0.574

High

1330726

EVI5L
EVI5-like protein

2

1

High-throughput

0.574

High

1330741

XPO4
Exportin-4

2

1

High-throughput

0.574

High

1330744

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

1

High-throughput

0.574

High

1330750

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

1330766

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

2

3

High-throughput

0.574

High

1226408

TBC9B
TBC1 domain family member 9B

1

1

High-throughput

0.536

High

178333

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.513

High

211821

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

565665

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.513

High

1330734

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.513

High

1330752

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

1330762

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.513

High

1330756

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

134090

IPO5
Importin-5

1

5

High-throughput

0.445

High

472098

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.445

High

580804

PVR
Poliovirus receptor

1

2

High-throughput

0.445

High

1330715

CADM4
Cell adhesion molecule 4

1

1

High-throughput

0.445

High

1309849

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.426

High

1330720

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.426

High

1330725

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.426

High

1330740

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.426

High

1330754

ATX10
Ataxin-10

1

0

High-throughput

0.426

High

505638

ELFN1
Protein ELFN1

1

2

High-throughput

0.407

High

1101756

PTK7
Inactive tyrosine-protein kinase 7

1

1

High-throughput

0.407

High

1195634

Q4LE60
TNPO2 variant protein

1

7

High-throughput

0.407

High

1209007

PPR29
Protein phosphatase 1 regulatory subunit 29

1

1

High-throughput

0.407

High

1203726

TTMP
TPA-induced transmembrane protein

4

0

High-throughput

0.364

High

208068

TTI1
TELO2-interacting protein 1 homolog

3

0

High-throughput

0.345

High

1229176

INT3
Integrator complex subunit 3

3

0

High-throughput

0.345

High

1278612

HEAT3
HEAT repeat-containing protein 3

3

0

High-throughput

0.345

High

1287756

NOP9
Nucleolar protein 9

3

0

High-throughput

0.345

High

1330723

SYMPK
Symplekin

3

0

High-throughput

0.345

High

1330729

SAAL1
Protein SAAL1

3

0

High-throughput

0.345

High

167104

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.328

High

173726

BTAF1
TATA-binding protein-associated factor 172

2

0

High-throughput

0.328

High

216105

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

2

0

High-throughput

0.328

High

317891

LTN1
E3 ubiquitin-protein ligase listerin

2

0

High-throughput

0.328

High

704446

GRAN
Grancalcin

2

0

High-throughput

0.328

High

834680

TNFL9
Tumor necrosis factor ligand superfamily member 9

2

0

High-throughput

0.328

High

897592

KNTC1
Kinetochore-associated protein 1

2

0

High-throughput

0.328

High

906321

GPC3
Glypican-3

2

0

High-throughput

0.328

High

1085250

NU160
Nuclear pore complex protein Nup160

2

0

High-throughput

0.328

High

1121127

UBE4A
Ubiquitin conjugation factor E4 A

2

0

High-throughput

0.328

High

1159755

OCLN
Occludin

2

0

High-throughput

0.328

High

1177603

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

0

High-throughput

0.328

High

1215446

DEP1A
DEP domain-containing protein 1A

2

0

High-throughput

0.328

High

1238553

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.328

High

1251537

THADA
tRNA

2

0

High-throughput

0.328

High

1275941

SETX
Probable helicase senataxin

2

0

High-throughput

0.328

High

1325267

VPS8
Vacuolar protein sorting-associated protein 8 homolog

2

0

High-throughput

0.328

High

1330716

EXOC6
Exocyst complex component 6

2

0

High-throughput

0.328

High

1330718

CIP2A
Protein CIP2A

2

0

High-throughput

0.328

High

1330728

HOOK2
Protein Hook homolog 2

2

0

High-throughput

0.328

High

1330732

RADIL
Ras-associating and dilute domain-containing protein

2

0

High-throughput

0.328

High

1330736

XPO6
Exportin-6

2

0

High-throughput

0.328

High

1330742

TTC12
Tetratricopeptide repeat protein 12

2

0

High-throughput

0.328

High

1330743

COG4
Conserved oligomeric Golgi complex subunit 4

2

0

High-throughput

0.328

High

1330745

NRN1
Neuritin

2

0

High-throughput

0.328

High

1330747

SOSSC
SOSS complex subunit C

2

0

High-throughput

0.328

High

1330748

F1142
Protein FAM114A2

2

0

High-throughput

0.328

High

1330760

S39AA
Zinc transporter ZIP10

2

0

High-throughput

0.328

High

1330764

SNX14
Sorting nexin-14

2

0

High-throughput

0.328

High

1330767

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

0

High-throughput

0.328

High

423805

APOD
Apolipoprotein D

2

0

High-throughput

0.316

High

932739

EMP3
Epithelial membrane protein 3

2

0

High-throughput

0.316

High

1330749

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

0

High-throughput

0.313

High

65308

RFOX3
RNA binding protein fox-1 homolog 3

1

0

High-throughput

0.279

Low

155607

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.279

Low

217322

PROM1
Prominin-1

1

0

High-throughput

0.279

Low

710365

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.279

Low

788535

SCNNA
Epithelial sodium channel subunit alpha

1

0

High-throughput

0.279

Low

1083278

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.279

Low

1204875

MKS3
Meckelin

1

0

High-throughput

0.279

Low

1330722

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.279

Low

1330751

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.279

Low

1330753

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.279

Low

1330759

ENPP5
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

1

0

High-throughput

0.279

Low

299883

C1QRF
C1q-related factor

1

0

High-throughput

0.232

Low

351139

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.232

Low

608304

EGLN
Endoglin

1

0

High-throughput

0.232

Low

1211074

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low

1330714

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.232

Low

1330717

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.232

Low

1330738

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.232

Low

1330739

MXRA8
Matrix remodeling-associated protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025