Protein: IST2
Increased sodium tolerance protein 2

Gene: IST2
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P38250

Gene Ontology (top 5):
GO:0005254 - chloride channel activity
GO:0005886 - plasma membrane
GO:0008289 - lipid binding
GO:0032541 - cortical endoplasmic reticulum
GO:0033101 - cellular bud membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

796670

OSH6
Oxysterol-binding protein homolog 6

3

1

Small-scale

0.670

High

392632

HSP82
ATP-dependent molecular chaperone HSP82

3

1

High-throughput

0.640

High

523742

HSP71
Heat shock protein SSA1

3

1

High-throughput

0.633

High

735823

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

0

Small-scale

0.588

High

796652

IST2
Increased sodium tolerance protein 2

1

0

Small-scale

0.586

High

796659

YNT4
Uncharacterized plasma membrane protein YNL194C

1

0

High-throughput

0.518

High

656442

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

656756

KC12
Casein kinase I homolog 2

1

1

High-throughput

0.501

High

796672

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.501

High

796691

SKM1
Serine/threonine-protein kinase SKM1

1

1

High-throughput

0.501

High

796655

OSH7
Oxysterol-binding protein homolog 7

1

1

Small-scale

0.481

High

579282

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

645246

GAS1
1,3-beta-glucanosyltransferase GAS1

1

2

High-throughput

0.479

High

796673

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

2

High-throughput

0.479

High

420923

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.458

High

569400

DPM1
Dolichol-phosphate mannosyltransferase

1

0

Small-scale

0.458

High

740329

SNQ2
Protein SNQ2

1

0

High-throughput

0.458

High

746426

SSO1
Protein SSO1

1

0

High-throughput

0.458

High

778977

MYO3
Myosin-3

1

0

High-throughput

0.458

High

796521

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.458

High

796658

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

Small-scale

0.458

High

796660

QDR2
Quinidine resistance protein 2

1

0

High-throughput

0.458

High

796664

EXG2
Glucan 1,3-beta-glucosidase 2

1

0

High-throughput

0.458

High

796677

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.458

High

796680

FMP27
Protein FMP27, mitochondrial

1

0

High-throughput

0.458

High

796681

YL413
Cell membrane protein YLR413W

1

0

High-throughput

0.458

High

796687

MRH1
Protein MRH1

1

0

High-throughput

0.458

High

796688

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.458

High

796692

ATG40
Autophagy-related protein 40

1

0

Small-scale

0.458

High

740569

IME2
Meiosis induction protein kinase IME2/SME1

1

1

High-throughput

0.457

High

526521

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

796683

GAS5
1,3-beta-glucanosyltransferase GAS5

1

2

High-throughput

0.437

High

544641

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

706918

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.335

High

510430

HSP77
Import motor subunit, mitochondrial

2

0

High-throughput

0.318

High

796667

BTN2
Protein BTN2

1

0

Small-scale

0.276

Low

642374

MCK1
Protein kinase MCK1

1

0

High-throughput

0.261

Low

796654

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.261

Low

796665

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

796669

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.261

Low

796685

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.261

Low

364494

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.249

Low

454295

CARP
Saccharopepsin

1

0

High-throughput

0.249

Low

679607

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

780739

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

794924

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.249

Low

796653

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

796656

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

796657

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

Small-scale

0.249

Low

796661

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

796662

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

796663

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

796666

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

796668

PGA2
Processing of GAS1 and ALP protein 2

1

0

High-throughput

0.249

Low

796671

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

796674

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.249

Low

796675

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

796676

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

796678

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

796679

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

796682

EXP1
ER export of PMA1 protein 1

1

0

High-throughput

0.249

Low

796684

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

796686

CWC2
Pre-mRNA-splicing factor CWC2

1

0

High-throughput

0.249

Low

796689

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.249

Low

796690

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

792777

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

675948

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

780097

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025