Protein: CWC2
Pre-mRNA-splicing factor CWC2 (Complexed with CEF1 protein 2) (PRP19-associated complex protein 40) (Synthetic lethal with CLF1 protein 3)

Gene: CWC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: Q12046

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0008270 - zinc ion binding
GO:0017070 - U6 snRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700162

PRP45
Pre-mRNA-processing protein 45

6

5

Small-scale

0.949

High

751804

PRP8
Pre-mRNA-splicing factor 8

6

5

Small-scale

0.949

High

1065578

RU2A
U2 small nuclear ribonucleoprotein A'

5

5

Small-scale

0.922

High

796472

SLT11
Pre-mRNA-splicing factor SLT11

3

2

High-throughput

0.861

High

638091

ISY1
Pre-mRNA-splicing factor ISY1

3

2

High-throughput

0.847

High

672084

BUD31
Pre-mRNA-splicing factor BUD31

3

2

High-throughput

0.839

High

863103

CWC26
Pre-mRNA-splicing factor CWC26

3

1

High-throughput

0.839

High

1047395

RSE1
Pre-mRNA-splicing factor RSE1

3

4

High-throughput

0.839

High

1065107

NCBP2
Nuclear cap-binding protein subunit 2

3

9

High-throughput

0.827

High

826531

IST3
U2 snRNP component IST3

3

10

High-throughput

0.805

High

757553

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.789

High

826555

MSL1
U2 small nuclear ribonucleoprotein B''

2

11

High-throughput

0.776

High

739218

PRP19
Pre-mRNA-processing factor 19

11

4

Small-scale

0.761

High

1043514

CEF1
Pre-mRNA-splicing factor CEF1

7

5

Small-scale

0.748

High

892797

SF3B1
U2 snRNP component HSH155

2

6

High-throughput

0.737

High

1037762

CUS1
Cold sensitive U2 snRNA suppressor 1

2

2

High-throughput

0.737

High

1084189

HSH49
Protein HSH49

2

9

High-throughput

0.737

High

1084185

CLF1
Pre-mRNA-splicing factor CLF1

6

9

Small-scale

0.733

High

702291

YJU2
Splicing factor YJU2

6

2

Small-scale

0.732

High

744179

BRR2
Pre-mRNA-splicing helicase BRR2

5

15

Small-scale

0.718

High

1044952

SYF1
Pre-mRNA-splicing factor SYF1

5

8

Small-scale

0.718

High

1084187

PRP46
Pre-mRNA-splicing factor PRP46

5

3

Small-scale

0.718

High

780236

SN114
Pre-mRNA-splicing factor SNU114

4

4

High-throughput

0.699

High

829966

PRP17
Pre-mRNA-processing factor 17

4

4

High-throughput

0.699

High

817177

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

6

High-throughput

0.694

High

933153

RUXF
Small nuclear ribonucleoprotein F

4

4

High-throughput

0.687

High

847842

SMD3
Small nuclear ribonucleoprotein Sm D3

3

6

High-throughput

0.667

High

919738

CWC22
Pre-mRNA-splicing factor CWC22

3

1

High-throughput

0.667

High

1036188

SMD1
Small nuclear ribonucleoprotein Sm D1

3

2

High-throughput

0.667

High

923323

CWC24
Pre-mRNA-splicing factor CWC24

1

0

High-throughput

0.656

High

923942

CWC25
Pre-mRNA-splicing factor CWC25

3

2

High-throughput

0.650

High

1054392

SMD2
Small nuclear ribonucleoprotein Sm D2

3

1

High-throughput

0.650

High

628241

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

11

Small-scale

0.646

High

664627

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

3

11

Small-scale

0.646

High

919228

SYF2
Pre-mRNA-splicing factor SYF2

3

0

High-throughput

0.638

High

1053566

SN309
Pre-mRNA-splicing factor SNT309

3

0

High-throughput

0.638

High

1037093

SPP2
Pre-mRNA-splicing factor SPP2

3

0

Small-scale

0.632

High

1042540

CWC21
Pre-mRNA-splicing factor CWC21

3

0

Small-scale

0.628

High

797699

NTC20
Pre-mRNA-splicing factor NTC20

3

0

High-throughput

0.622

High

1044029

CWC15
Pre-mRNA-splicing factor CWC15

3

0

High-throughput

0.622

High

403693

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

8

High-throughput

0.618

High

625143

PRP9
Pre-mRNA-splicing factor PRP9

1

3

High-throughput

0.618

High

1059214

PRP11
Pre-mRNA-splicing factor PRP11

1

4

High-throughput

0.618

High

1038544

SLU7
Pre-mRNA-splicing factor SLU7

2

1

High-throughput

0.611

High

642488

MCK1
Protein kinase MCK1

1

5

High-throughput

0.579

High

1084188

SKM1
Serine/threonine-protein kinase SKM1

1

1

High-throughput

0.579

High

917504

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

10

High-throughput

0.574

High

820849

RUXG
Small nuclear ribonucleoprotein G

2

7

High-throughput

0.571

High

914889

CWC23
Pre-mRNA-splicing factor CWC23

1

2

High-throughput

0.536

High

527954

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.504

High

546650

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.504

High

801989

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.494

High

590229

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

11

High-throughput

0.479

High

739284

PRP21
Pre-mRNA-splicing factor PRP21

1

4

High-throughput

0.479

High

1057305

RDS3
Pre-mRNA-splicing factor RDS3

1

3

High-throughput

0.479

High

752053

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.458

High

918873

DRN1
CWF19-like protein DRN1

1

2

High-throughput

0.445

High

460749

CDC4
Cell division control protein 4

1

1

High-throughput

0.417

High

825183

NU159
Nucleoporin NUP159

1

1

High-throughput

0.417

High

394992

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.407

High

592561

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

609247

CLC1
Clathrin light chain

1

3

High-throughput

0.407

High

727386

HS104
Heat shock protein 104

1

3

High-throughput

0.407

High

742622

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

820059

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.407

High

836947

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.407

High

893176

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.407

High

1044266

WDR59
Maintenance of telomere capping protein 5

1

2

High-throughput

0.407

High

1084186

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

1055005

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.328

High

781593

NTR2
Pre-mRNA-splicing factor NTR2

2

0

High-throughput

0.318

High

781983

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.249

Low

796686

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.249

Low

798675

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.238

Low

1055039

TDA5
Uncharacterized oxidoreductase TDA5

1

0

High-throughput

0.238

Low

416924

CDC25
Cell division control protein 25

1

0

High-throughput

0.232

Low

646204

SLY1
Protein SLY1

1

0

High-throughput

0.232

Low

723212

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

1035303

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.232

Low

1065101

FEX1
Fluoride export protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025