Protein: LCF4
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Fatty acid activator 4) (Fatty acyl-CoA synthetase) (FACS) (Long-chain acyl-CoA synthetase 4)

Gene: LCF4, FAA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: P47912

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

544044

HSC82
ATP-dependent molecular chaperone HSC82

3

4

High-throughput

0.646

High

746650

FAT1
Very long-chain fatty acid transport protein

1

1

Small-scale

0.618

High

758989

LCF3
Long-chain-fatty-acid--CoA ligase 3

1

4

High-throughput

0.618

High

814699

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

4

High-throughput

0.618

High

814733

PGC1
Phosphatidylglycerol phospholipase C

2

0

High-throughput

0.585

High

491743

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.571

High

494370

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.571

High

594342

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.536

High

604274

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.536

High

814727

PSR2
Probable phosphatase PSR2

1

1

High-throughput

0.536

High

814728

RBX1
RING-box protein HRT1

1

2

High-throughput

0.536

High

797462

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.533

High

424598

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.513

High

424883

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

614515

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

0

High-throughput

0.513

High

696463

FIMB
Fimbrin

1

0

High-throughput

0.513

High

710514

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.513

High

814707

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

814715

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.513

High

691825

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.489

High

715352

SPT7
Transcriptional activator SPT7

1

5

High-throughput

0.489

High

744646

TAF5
Transcription initiation factor TFIID subunit 5

1

3

High-throughput

0.489

High

758678

TEM1
Protein TEM1

1

5

High-throughput

0.489

High

814714

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.489

High

814717

UTP5
U3 small nucleolar RNA-associated protein 5

1

4

High-throughput

0.489

High

404353

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

411039

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

366554

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.479

High

402981

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

407166

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

482342

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

524378

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

691081

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

700976

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

746517

IMB2
Importin subunit beta-2

1

1

High-throughput

0.479

High

753871

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

764996

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

814711

NUM1
Nuclear migration protein NUM1

1

3

High-throughput

0.479

High

814716

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

814718

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

814737

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

814738

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

814725

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.460

High

343407

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

408001

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

485767

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.458

High

549821

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.458

High

572804

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.458

High

631967

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

688320

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

730001

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

748154

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

752546

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

755099

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.458

High

755585

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.458

High

763171

FHP
Flavohemoprotein

1

0

High-throughput

0.458

High

777122

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

814700

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

814706

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.458

High

814708

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

814712

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

814720

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

814726

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

814729

SGO1
Shugoshin

1

0

High-throughput

0.458

High

814730

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

814734

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

814735

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

814736

HSP42
Heat shock protein 42

1

0

High-throughput

0.458

High

477356

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.457

High

368201

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

511905

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

695044

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

768859

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

356574

H4
Histone H4

1

1

High-throughput

0.437

High

628238

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

662688

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

730854

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

762357

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

792491

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

814701

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

814710

H3
Histone H3

1

3

High-throughput

0.437

High

814732

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

360944

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

520279

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.426

High

556150

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

700505

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.426

High

762144

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

785098

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

814704

YGI2
Uncharacterized protein YGL082W

1

0

High-throughput

0.426

High

584176

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

696550

DSS4
Protein DSS4

1

0

High-throughput

0.279

Low

707888

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.279

Low

814705

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.279

Low

814713

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.279

Low

814719

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.279

Low

378367

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

748494

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.251

Low

769984

PEX17
Peroxisomal membrane protein PEX17

1

0

High-throughput

0.251

Low

814724

YP097
PX domain-containing protein YPR097W

1

0

Small-scale

0.251

Low

383233

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

413597

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

471143

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

472280

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

480762

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

606695

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

633875

SGF29
SAGA-associated factor 29

1

0

Small-scale

0.249

Low

756971

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

775772

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

776455

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

814709

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

814721

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

814722

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

814723

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

814731

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

757437

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

814702

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.232

Low

814703

SPT20
Transcription factor SPT20

1

0

High-throughput

0.232

Low

814739

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024