Protein: SPC25
Kinetochore protein SPC25

Gene: SPC25
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P40014

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0005634 - nucleus
GO:0007059 - chromosome segregation
GO:0031262 - Ndc80 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817026

SPC24
Kinetochore protein SPC24

27

0

Small-scale

0.737

High

816990

NDC80
Kinetochore protein NDC80

14

0

Small-scale

0.730

High

816993

DSN1
Kinetochore-associated protein DSN1

11

0

Small-scale

0.722

High

817000

CENPT
Inner kinetochore subunit CNN1

7

0

Small-scale

0.721

High

755242

NUF2
Kinetochore protein NUF2

6

0

Small-scale

0.706

High

814073

MTW1
Kinetochore-associated protein MTW1

4

0

Small-scale

0.669

High

817010

KNL1
Outer kinetochore KNL1 complex subunit SPC105

3

0

Small-scale

0.633

High

817018

MPS1
Serine/threonine-protein kinase MPS1

2

0

Small-scale

0.592

High

817004

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.576

High

816987

SPC25
Kinetochore protein SPC25

2

0

Small-scale

0.570

High

817022

ADA2
SAGA complex subunit ADA2

2

0

High-throughput

0.570

High

817044

NSL1
Kinetochore-associated protein NSL1

2

0

Small-scale

0.569

High

816995

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.486

High

684911

DAL80
Nitrogen regulatory protein DAL80

1

1

High-throughput

0.481

High

806860

SKN7
Transcription factor SKN7

1

1

High-throughput

0.481

High

816996

GZF3
Protein GZF3

1

1

High-throughput

0.481

High

817005

HMS2
Probable transcription factor HMS2

1

1

High-throughput

0.481

High

817001

STU2
Protein STU2

1

0

Small-scale

0.480

High

438145

NOT2
General negative regulator of transcription subunit 2

1

0

High-throughput

0.460

High

454039

GCR1
Glycolytic genes transcriptional activator GCR1

1

0

High-throughput

0.460

High

466791

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.460

High

483781

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.460

High

577553

CYC8
General transcriptional corepressor CYC8

1

0

High-throughput

0.460

High

585710

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.460

High

617795

SNF6
Transcription regulatory protein SNF6

1

0

High-throughput

0.460

High

624462

RDS2
Regulator of drug sensitivity 2

1

0

High-throughput

0.460

High

625097

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.460

High

646044

KIN3
Serine/threonine-protein kinase KIN3

1

0

High-throughput

0.460

High

664297

SSD1
Protein SSD1

1

0

High-throughput

0.460

High

670273

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.460

High

678684

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

High-throughput

0.460

High

726268

DEP1
Transcriptional regulatory protein DEP1

1

0

High-throughput

0.460

High

736789

AROG
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

1

0

High-throughput

0.460

High

745475

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.460

High

749676

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

750252

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.460

High

750672

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

777053

BDF1
Bromodomain-containing factor 1

1

0

High-throughput

0.460

High

781901

SPC34
DASH complex subunit SPC34

1

0

High-throughput

0.460

High

803984

RSC30
Chromatin structure-remodeling complex protein RSC30

1

0

High-throughput

0.460

High

804021

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.460

High

806257

SSP1
Sporulation-specific protein 1

1

0

High-throughput

0.460

High

813330

MBP1
Transcription factor MBP1

1

0

High-throughput

0.460

High

813800

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.460

High

815645

LIS1
Nuclear distribution protein PAC1

1

0

High-throughput

0.460

High

816989

NUP82
Nucleoporin NUP82

1

0

High-throughput

0.460

High

816991

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.460

High

816992

SDS3
Transcriptional regulatory protein SDS3

1

0

High-throughput

0.460

High

816994

MND2
Anaphase-promoting complex subunit MND2

1

0

High-throughput

0.460

High

816997

EPL1
Enhancer of polycomb-like protein 1

1

0

High-throughput

0.460

High

817008

PHO23
Transcriptional regulatory protein PHO23

1

0

High-throughput

0.460

High

817009

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.460

High

817011

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.460

High

817015

SOK2
Protein SOK2

1

0

High-throughput

0.460

High

817019

DAD4
DASH complex subunit DAD4

1

0

High-throughput

0.460

High

817020

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.460

High

817021

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.460

High

817023

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

817030

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

817031

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

817032

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.460

High

817037

MFG1
Morphogenetic regulator of filamentous growth protein 1

1

0

High-throughput

0.460

High

817042

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

817043

YP022
Zinc finger protein YPR022C

1

0

High-throughput

0.460

High

817045

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

817047

NSI1
RNA polymerase I termination factor

1

0

High-throughput

0.460

High

817048

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.460

High

707196

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

797880

CENPU
Inner kinetochore subunit AME1

1

0

Small-scale

0.458

High

817012

YBP2
YAP1-binding protein 2

1

0

Small-scale

0.458

High

817025

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.458

High

817040

SGO1
Shugoshin

1

0

High-throughput

0.458

High

817029

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.438

High

736010

SP110
Spindle pole body component 110

1

0

Small-scale

0.426

High

741651

HSP7F
Heat shock protein homolog SSE1

1

0

High-throughput

0.426

High

779760

DYHC
Dynein heavy chain, cytoplasmic

2

0

High-throughput

0.310

High

796313

FL2D
Protein MUM2

2

0

High-throughput

0.310

High

816998

FAR7
Factor arrest protein 7

2

0

High-throughput

0.306

High

782938

JNM1
Nuclear migration protein JNM1

2

0

High-throughput

0.304

High

817035

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.269

Low

781091

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.265

Low

150172

THP2
THO complex subunit THP2

1

0

High-throughput

0.251

Low

672415

STE50
Protein STE50

1

0

High-throughput

0.251

Low

677753

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

0

High-throughput

0.251

Low

753089

NIP80
Protein NIP100

1

0

High-throughput

0.251

Low

802512

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.251

Low

803293

ETP1
RING finger protein ETP1

1

0

High-throughput

0.251

Low

804894

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

806284

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.251

Low

809185

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.251

Low

814902

VPS52
Vacuolar protein sorting-associated protein 52

1

0

High-throughput

0.251

Low

816988

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

816999

KEG1
Beta-1,6-glucan synthesis-associated protein KEG1

1

0

High-throughput

0.251

Low

817002

STB2
Protein STB2

1

0

High-throughput

0.251

Low

817003

ATG36
Autophagy-related protein 36

1

0

High-throughput

0.251

Low

817006

ASK10
Activator of SKN7 protein 10

1

0

High-throughput

0.251

Low

817007

ASE1
Anaphase spindle elongation protein

1

0

High-throughput

0.251

Low

817013

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

817014

PXR1
Protein PXR1

1

0

High-throughput

0.251

Low

817016

BSC5
Bypass of stop codon protein 5

1

0

High-throughput

0.251

Low

817024

CEF1
Pre-mRNA-splicing factor CEF1

1

0

High-throughput

0.251

Low

817033

IRC3
Putative ATP-dependent helicase IRC3

1

0

High-throughput

0.251

Low

817034

MDM36
Mitochondrial distribution and morphology protein 36

1

0

High-throughput

0.251

Low

817036

ATG20
Autophagy-related protein 20

1

0

High-throughput

0.251

Low

817039

YL031
Putative uncharacterized protein YLR031W

1

0

High-throughput

0.251

Low

817041

YP257
Uncharacterized membrane protein YPL257W

1

0

High-throughput

0.251

Low

817046

GYP5
GTPase-activating protein GYP5

1

0

High-throughput

0.251

Low

817049

HPH1
Protein HPH1

1

0

High-throughput

0.251

Low

817017

FAR11
Factor arrest protein 11

1

0

High-throughput

0.249

Low

817027

FAR8
Factor arrest protein 8

1

0

High-throughput

0.249

Low

817028

FAR10
Factor arrest protein 10

1

0

High-throughput

0.249

Low

817038

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.249

Low

631933

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025