Protein: SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SLX8) (Synthetic lethal of unknown function protein 8)

Gene: SLX8
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: P40072

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000776 - kinetochore
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585711

UBC4
Ubiquitin-conjugating enzyme E2 4

3

1

Small-scale

0.845

High

745477

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

13

0

Small-scale

0.726

High

585752

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

1

Small-scale

0.647

High

419751

H2A2
Histone H2A.2

1

0

High-throughput

0.631

High

818089

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.621

High

509574

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.614

High

818085

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

Small-scale

0.614

High

818100

SMT3
Ubiquitin-like protein SMT3

3

0

Small-scale

0.605

High

818099

SIZ2
E3 SUMO-protein ligase SIZ2

2

1

Small-scale

0.594

High

818092

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.590

High

515409

HMAL2
Silenced mating-type protein ALPHA2

2

0

Small-scale

0.577

High

818095

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

Small-scale

0.536

High

814199

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.515

High

739304

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.504

High

818098

ELG1
Telomere length regulation protein ELG1

1

0

Small-scale

0.504

High

382126

H4
Histone H4

1

0

High-throughput

0.493

High

448969

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

818088

ASE1
Anaphase spindle elongation protein

1

0

High-throughput

0.493

High

809320

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

818093

ABF2
ARS-binding factor 2, mitochondrial

1

0

High-throughput

0.493

High

818094

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

448455

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.480

High

602481

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

748849

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

672319

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.470

High

805820

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.460

High

818097

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.460

High

818096

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

392805

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

524089

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526809

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

545044

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

579477

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

741668

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

818086

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

818091

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

752312

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

804193

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

555086

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

818090

NUP84
Nucleoporin NUP84

1

0

Small-scale

0.249

Low

763154

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.238

Low

818087

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025