Protein: SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 (EC 2.3.2.27) (Hexose metabolism-related protein HEX3) (RING-type E3 ubiquitin transferase SLX5) (Synthetic lethal of unknown function protein 5)

Gene: SLX5
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: P32828

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0005634 - nucleus
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

745477

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

13

0

Small-scale

0.726

High

745510

SMT3
Ubiquitin-like protein SMT3

9

0

Small-scale

0.714

High

585693

UBC4
Ubiquitin-conjugating enzyme E2 4

4

1

Small-scale

0.686

High

745464

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

4

0

Small-scale

0.649

High

745499

EUC1
Transcription factor-like protein EUC1

3

0

Small-scale

0.644

High

745466

CENPA
Histone H3-like centromeric protein CSE4

3

0

Small-scale

0.613

High

738732

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

3

0

Small-scale

0.612

High

515408

HMAL2
Silenced mating-type protein ALPHA2

2

0

Small-scale

0.603

High

585747

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

1

Small-scale

0.602

High

745495

NSE5
Non-structural maintenance of chromosome element 5

2

0

Small-scale

0.587

High

745498

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

Small-scale

0.586

High

745507

ELG1
Telomere length regulation protein ELG1

2

0

Small-scale

0.583

High

557685

SRS2
ATP-dependent DNA helicase SRS2

2

0

Small-scale

0.569

High

745476

YEN1
Holliday junction resolvase YEN1

1

0

Small-scale

0.558

High

745505

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.529

High

448442

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.513

High

712756

PTP2
Tyrosine-protein phosphatase 2

1

0

High-throughput

0.513

High

745480

LSM1
LSM1-LSM7 complex subunit LSM1

1

1

High-throughput

0.508

High

745490

LSM3
LSM complex subunit LSM3

1

1

High-throughput

0.508

High

444758

SIR2
NAD-dependent histone deacetylase SIR2

1

0

Small-scale

0.504

High

739299

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.504

High

656405

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

656728

KC12
Casein kinase I homolog 2

1

1

High-throughput

0.501

High

745508

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

Small-scale

0.501

High

745506

THP3
Protein THP3

1

0

High-throughput

0.493

High

625081

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.486

High

745471

LIN1
Protein LIN1

1

0

Small-scale

0.486

High

745492

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.486

High

745485

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.481

High

509463

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.480

High

745465

HSL1
Probable serine/threonine-protein kinase HSL1

1

0

High-throughput

0.480

High

745469

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

745494

SKY1
Serine/threonine-protein kinase SKY1

1

0

High-throughput

0.480

High

745501

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

745513

NCB2
Negative cofactor 2 complex subunit beta

1

0

Small-scale

0.480

High

392458

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.479

High

486106

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.479

High

645344

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

745491

ACT
Actin

1

0

High-throughput

0.479

High

674399

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.460

High

704861

KIP1
Kinesin-like protein KIP1

1

0

High-throughput

0.460

High

734250

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.460

High

734402

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.460

High

745467

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

745470

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.460

High

745472

AURK
Aurora kinase

1

0

High-throughput

0.460

High

745475

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

745478

NDC80
Kinetochore protein NDC80

1

0

Small-scale

0.460

High

745482

BIR1
Chromosomal passenger complex protein BIR1

1

0

High-throughput

0.460

High

745493

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

706596

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

366981

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.457

High

452864

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

745496

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

745511

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

745473

MET30
F-box protein MET30

1

0

High-throughput

0.438

High

745502

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.438

High

381980

H4
Histone H4

1

0

High-throughput

0.426

High

544261

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

745486

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

745483

JSN1
Protein JSN1

1

0

High-throughput

0.282

High

745488

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.279

Low

745504

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.279

Low

745468

YRO2
Protein YRO2

1

0

High-throughput

0.269

Low

745509

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.269

Low

704677

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.261

Low

745479

PRK1
Actin-regulating kinase PRK1

1

0

High-throughput

0.261

Low

745487

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

450553

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

453498

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.261

Low

644739

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

745497

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.249

Low

745500

ECM7
Protein ECM7

1

0

High-throughput

0.238

Low

745512

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.238

Low

745474

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.232

Low

745481

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

745484

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

745489

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

745503

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025