Protein: NOC2
Nucleolar complex protein 2

Gene: NOC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 210
UniProt ID: P39744

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814418

MAK21
Ribosome biogenesis protein MAK21

18

6

Small-scale

0.987

High

814400

NOC3
Nucleolar complex-associated protein 3

12

2

Small-scale

0.979

High

814385

RRP5
rRNA biogenesis protein RRP5

12

1

Small-scale

0.757

High

791058

NOP4
Nucleolar protein 4

8

1

Small-scale

0.753

High

814382

ERB1
Ribosome biogenesis protein ERB1

8

1

Small-scale

0.752

High

814349

PESC
Pescadillo homolog

10

1

Small-scale

0.750

High

814333

NOP2
25S rRNA

8

2

Small-scale

0.748

High

814326

NUG1
Nuclear GTP-binding protein NUG1

9

1

Small-scale

0.748

High

814420

DBP10
ATP-dependent RNA helicase DBP10

7

1

High-throughput

0.747

High

814332

RLP7
Ribosome biogenesis protein RLP7

8

2

Small-scale

0.745

High

814374

HAS1
ATP-dependent RNA helicase HAS1

8

3

Small-scale

0.745

High

682287

SPB4
ATP-dependent rRNA helicase SPB4

8

3

Small-scale

0.744

High

814414

YTM1
Ribosome biogenesis protein YTM1

7

1

Small-scale

0.740

High

814359

NOP15
Ribosome biogenesis protein 15

7

3

Small-scale

0.740

High

804611

SSF1
Ribosome biogenesis protein SSF1

7

1

Small-scale

0.739

High

746628

DRS1
ATP-dependent RNA helicase DRS1

6

2

Small-scale

0.723

High

763075

RRP1
Ribosomal RNA-processing protein 1

6

2

Small-scale

0.723

High

782337

RPF2
Ribosome biogenesis protein RPF2

10

0

Small-scale

0.722

High

814336

LOC1
60S ribosomal subunit assembly/export protein LOC1

7

0

Small-scale

0.718

High

814327

NSA2
Ribosome biogenesis protein NSA2

8

0

Small-scale

0.715

High

803863

CIC1
Proteasome-interacting protein CIC1

7

0

Small-scale

0.712

High

814402

NOP12
Nucleolar protein 12

5

2

Small-scale

0.711

High

814373

NOG1
Nucleolar GTP-binding protein 1

7

0

Small-scale

0.709

High

814403

BRX1
Ribosome biogenesis protein BRX1

5

4

Small-scale

0.707

High

677203

SPB1
27S pre-rRNA

5

1

Small-scale

0.704

High

793479

MAK5
ATP-dependent RNA helicase MAK5

5

3

Small-scale

0.704

High

780267

EBP2
rRNA-processing protein EBP2

6

0

Small-scale

0.697

High

814346

NSA1
Ribosome biogenesis protein NSA1

6

0

Small-scale

0.695

High

805047

RPF1
Ribosome production factor 1

6

0

High-throughput

0.695

High

750084

MRT4
Ribosome assembly factor MRT4

4

2

Small-scale

0.686

High

534111

MAK16
Protein MAK16

4

1

Small-scale

0.680

High

814410

RRS1
Regulator of ribosome biosynthesis

5

0

Small-scale

0.678

High

814401

RLP24
Ribosome biogenesis protein RLP24

4

1

Small-scale

0.676

High

814325

NOP16
Nucleolar protein 16

5

0

Small-scale

0.672

High

814389

FKBP4
FK506-binding protein 4

3

3

High-throughput

0.669

High

637222

PWP1
Periodic tryptophan protein 1

3

2

High-throughput

0.666

High

684737

RL5
Large ribosomal subunit protein uL18

4

0

Small-scale

0.657

High

814423

IF6
Eukaryotic translation initiation factor 6

4

0

Small-scale

0.657

High

780678

RRP14
Ribosomal RNA-processing protein 14

4

0

Small-scale

0.651

High

585279

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

1

High-throughput

0.650

High

781623

DBP7
ATP-dependent RNA helicase DBP7

3

3

High-throughput

0.650

High

513369

RL23B
Large ribosomal subunit protein uL14B

4

0

Small-scale

0.648

High

814323

NOC2
Nucleolar complex protein 2

3

1

High-throughput

0.646

High

738211

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

3

2

High-throughput

0.643

High

570024

RL3
Large ribosomal subunit protein uL3

4

1

Small-scale

0.626

High

544952

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

High-throughput

0.624

High

814348

UTP22
U3 small nucleolar RNA-associated protein 22

3

0

High-throughput

0.622

High

814405

NOP8
60S ribosome subunit biogenesis protein NOP8

3

0

High-throughput

0.618

High

814415

NOP53
Ribosome biogenesis protein NOP53

3

0

High-throughput

0.618

High

814395

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.618

High

601051

RL8A
Large ribosomal subunit protein eL8A

4

2

Small-scale

0.617

High

814357

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

2

High-throughput

0.614

High

814335

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

814376

RRP17
Ribosomal RNA-processing protein 17

3

0

High-throughput

0.613

High

814379

PUF6
Pumilio homology domain family member 6

3

0

Small-scale

0.613

High

814404

REXO4
RNA exonuclease 4

3

0

High-throughput

0.613

High

689040

RL16A
Large ribosomal subunit protein uL13A

2

2

Small-scale

0.611

High

814399

RIX7
Ribosome biogenesis ATPase RIX7

2

2

Small-scale

0.611

High

518026

SSBP1
Single-stranded nucleic acid-binding protein

2

1

High-throughput

0.595

High

814356

NOG2
Nucleolar GTP-binding protein 2

2

1

High-throughput

0.594

High

814352

H1
Histone H1

2

0

High-throughput

0.587

High

814358

NOP13
Nucleolar protein 13

2

0

Small-scale

0.585

High

433213

RL17A
Large ribosomal subunit protein uL22A

2

1

Small-scale

0.584

High

433655

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

633163

MAK11
Protein MAK11

2

1

Small-scale

0.584

High

814351

YG5X
Putative methyltransferase YGR283C

2

1

High-throughput

0.584

High

814381

UTP14
U3 small nucleolar RNA-associated protein 14

2

1

High-throughput

0.584

High

814383

YM91
Putative methyltransferase YMR310C

2

1

High-throughput

0.584

High

814391

DBP9
ATP-dependent RNA helicase DBP9

2

2

High-throughput

0.584

High

814416

SSF2
Ribosome biogenesis protein SSF2

2

1

High-throughput

0.584

High

814421

NOP58
Nucleolar protein 58

2

1

High-throughput

0.584

High

814377

DHR1
Probable ATP-dependent RNA helicase DHR1

2

0

High-throughput

0.576

High

579430

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

814328

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.571

High

410149

RL25
Large ribosomal subunit protein uL23

2

0

Small-scale

0.559

High

677405

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

758215

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

Small-scale

0.559

High

798220

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

814331

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

814340

URB2
Nucleolar pre-ribosomal-associated protein 2

2

0

High-throughput

0.559

High

814394

RRP15
Ribosomal RNA-processing protein 15

2

0

High-throughput

0.559

High

814411

NIP7
60S ribosome subunit biogenesis protein NIP7

2

0

Small-scale

0.559

High

814425

RRP12
Ribosomal RNA-processing protein 12

2

0

High-throughput

0.559

High

526752

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

751402

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.547

High

432591

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.536

High

721956

XPO1
Exportin-1

1

1

High-throughput

0.536

High

814343

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.536

High

814367

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

511205

RL20B
Large ribosomal subunit protein eL20B

2

1

Small-scale

0.533

High

427289

RLA0
Large ribosomal subunit protein uL10

2

2

Small-scale

0.521

High

666468

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.518

High

700240

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

814345

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

1

High-throughput

0.515

High

814417

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.515

High

814341

YMR1
Phosphoinositide 3-phosphatase

1

0

High-throughput

0.513

High

814355

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

814398

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

609061

SKI3
Superkiller protein 3

1

0

High-throughput

0.493

High

744553

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

0

High-throughput

0.493

High

809314

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

814388

PDP3
NuA3 HAT complex component PDP3

1

0

High-throughput

0.493

High

409734

RL24A
Large ribosomal subunit protein eL24A

1

1

Small-scale

0.479

High

419741

H2A2
Histone H2A.2

1

3

High-throughput

0.479

High

435981

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

441920

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

503390

RL11A
Large ribosomal subunit protein uL5A

1

1

Small-scale

0.479

High

512452

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

515262

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

531750

RL4A
Large ribosomal subunit protein uL4A

1

2

Small-scale

0.479

High

645424

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

679705

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

689221

RL16B
Large ribosomal subunit protein uL13B

1

2

High-throughput

0.479

High

707159

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

754284

DCA13
Protein SOF1

1

1

High-throughput

0.479

High

807075

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

814329

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

814337

ROK1
ATP-dependent RNA helicase ROK1

1

1

High-throughput

0.479

High

814338

MTR4
ATP-dependent RNA helicase DOB1

1

1

Small-scale

0.479

High

814354

DBP6
ATP-dependent RNA helicase DBP6

1

3

High-throughput

0.479

High

814360

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

814361

RCM1
25S rRNA

1

2

High-throughput

0.479

High

814362

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

814363

H3
Histone H3

1

4

High-throughput

0.479

High

814365

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

814372

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

814384

RTN1
Reticulon-like protein 1

1

1

High-throughput

0.479

High

814386

HRQ1
ATP-dependent helicase HRQ1

1

1

Small-scale

0.479

High

814390

JIP5
WD repeat-containing protein JIP5

1

2

High-throughput

0.479

High

814412

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

814380

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.460

High

814419

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.460

High

149777

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

403519

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.458

High

434026

RL33A
Large ribosomal subunit protein eL33A

1

0

Small-scale

0.458

High

435109

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436420

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

670738

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

673181

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

674639

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677930

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

709772

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

734992

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

781198

RL14A
Large ribosomal subunit protein eL14A

1

0

Small-scale

0.458

High

795818

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

802188

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

804108

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.458

High

806128

NMD3
60S ribosomal export protein NMD3

1

0

Small-scale

0.458

High

806612

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

808824

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

814324

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

814344

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

814347

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

814350

SDA1
Protein SDA1

1

0

High-throughput

0.458

High

814353

PAP2
Poly(A) RNA polymerase protein 2

1

0

Small-scale

0.458

High

814364

RL34A
Large ribosomal subunit protein eL34A

1

0

Small-scale

0.458

High

814378

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

814387

RSA3
Ribosome assembly protein 3

1

0

High-throughput

0.458

High

814406

SGO1
Shugoshin

1

0

High-throughput

0.458

High

814413

MDN1
Midasin

1

0

Small-scale

0.458

High

814422

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.458

High

814426

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.458

High

392767

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

524018

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

741625

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

752284

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

383132

RLA4
Large ribosomal subunit protein P2B

1

1

Small-scale

0.437

High

427573

RLA1
Large ribosomal subunit protein P1A

1

1

Small-scale

0.437

High

427702

RLA2
Large ribosomal subunit protein P2A

1

1

Small-scale

0.437

High

434166

RL36A
Large ribosomal subunit protein eL36A

1

1

Small-scale

0.437

High

434379

RL15A
Large ribosomal subunit protein eL15A

1

1

Small-scale

0.437

High

504225

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

514003

RL18B
Large ribosomal subunit protein eL18B

1

1

Small-scale

0.437

High

515106

RL19B
Large ribosomal subunit protein eL19

1

1

Small-scale

0.437

High

528825

RLA3
Large ribosomal subunit protein P1B

1

1

Small-scale

0.437

High

814424

RL13A
Large ribosomal subunit protein eL13A

1

1

Small-scale

0.437

High

804179

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

814330

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.426

High

814366

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

814407

FOLE
Folylpolyglutamate synthase

1

0

High-throughput

0.426

High

814334

RL10
Large ribosomal subunit protein uL16

2

0

Small-scale

0.305

High

799683

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

0

High-throughput

0.279

Low

814392

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.279

Low

814408

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

814393

NAT3
N-terminal acetyltransferase B complex catalytic subunit NAT3

1

0

High-throughput

0.269

Low

415020

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.249

Low

432848

RL9A
Large ribosomal subunit protein uL6A

1

0

Small-scale

0.249

Low

511428

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.249

Low

513021

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514292

RL12B
Large ribosomal subunit protein uL11B

1

0

Small-scale

0.249

Low

558734

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

734108

EF2
Elongation factor 2

1

0

High-throughput

0.249

Low

748404

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

753384

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778342

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

792524

RL32
Large ribosomal subunit protein eL32

1

0

Small-scale

0.249

Low

812315

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

814342

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

814368

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

814369

RL6A
Large ribosomal subunit protein eL6A

1

0

Small-scale

0.249

Low

814371

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

814375

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

814397

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

814409

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

553998

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.232

Low

671641

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

814339

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

814370

NU116
Nucleoporin NUP116/NSP116

1

0

Small-scale

0.232

Low

814396

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025