Protein: HSP31
Glutathione-independent glyoxalase HSP31 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31)

Gene: HSP31
Organism: Saccharomyces cerevisiae S288C
Interactions: 121
UniProt ID: Q04432

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0005737 - cytoplasm
GO:0010494 - cytoplasmic stress granule
GO:0019172 - glyoxalase III activity
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1046600

HSP31
Glutathione-independent glyoxalase HSP31

1

9

Small-scale

0.710

High

1046602

SNO4
Probable glutathione-independent glyoxalase SNO4

2

9

High-throughput

0.588

High

580032

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

752708

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.571

High

393301

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.568

High

1039034

IMA1
Importin subunit alpha

1

1

High-throughput

0.541

High

795683

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.513

High

727302

HS104
Heat shock protein 104

1

2

Small-scale

0.479

High

795529

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

735556

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.457

High

149948

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.445

High

525085

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

546201

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

742355

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

799695

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

High-throughput

0.445

High

819743

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

1046605

CYK2
Cytokinesis protein 2

1

1

High-throughput

0.445

High

359352

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

367809

ENO1
Enolase 1

1

0

High-throughput

0.426

High

376195

RAS1
Ras-like protein 1

1

0

High-throughput

0.426

High

394887

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

404989

PUR3
Phosphoribosylglycinamide formyltransferase

1

0

High-throughput

0.426

High

408347

GAL1
Galactokinase

1

0

High-throughput

0.426

High

531400

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

653898

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

672620

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.426

High

740613

IME2
Meiosis induction protein kinase IME2/SME1

1

0

High-throughput

0.426

High

751296

BUD2
Inhibitory regulator protein BUD2/CLA2

1

0

High-throughput

0.426

High

757905

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.426

High

763854

SKI2
Antiviral helicase SKI2

1

0

High-throughput

0.426

High

782183

LAS1
Protein LAS1

1

0

High-throughput

0.426

High

789791

ADCS
Aminodeoxychorismate synthase

1

0

High-throughput

0.426

High

808662

AURK
Aurora kinase

1

0

High-throughput

0.426

High

814744

EXO1
Exodeoxyribonuclease 1

1

0

High-throughput

0.426

High

835551

BUD6
Bud site selection protein 6

1

0

High-throughput

0.426

High

863183

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.426

High

893098

YG51
Uncharacterized protein YGR237C

1

0

High-throughput

0.426

High

916948

VID30
GID complex subunit 1

1

0

High-throughput

0.426

High

923815

PDR17
Phosphatidylinositol transfer protein PDR17

1

0

High-throughput

0.426

High

923959

YNX4
Uncharacterized globin-like protein YNL234W

1

0

High-throughput

0.426

High

924373

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.426

High

925492

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

932837

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.426

High

1026616

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

0

High-throughput

0.426

High

1033340

MDM1
Structural protein MDM1

1

0

High-throughput

0.426

High

1038422

YP067
Uncharacterized protein YPL067C

1

0

High-throughput

0.426

High

1046601

YMW4
Uncharacterized protein YMR074C

1

0

High-throughput

0.426

High

1046604

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.426

High

1046609

ELP1
Elongator complex protein 1

1

0

High-throughput

0.426

High

1046610

YD129
Uncharacterized protein YDL129W

1

0

High-throughput

0.426

High

435630

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.407

High

699427

CIN8
Kinesin-like protein CIN8

1

1

High-throughput

0.407

High

727685

TPS2
Trehalose-phosphatase

1

1

High-throughput

0.407

High

739766

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.407

High

737040

CDC3
Cell division control protein 3

2

0

High-throughput

0.307

High

826076

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.251

Low

680045

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

367399

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.232

Low

368748

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.232

Low

381252

H2B1
Histone H2B.1

1

0

High-throughput

0.232

Low

415245

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.232

Low

434649

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.232

Low

454269

MRS1
Mitochondrial RNA-splicing protein MRS1

1

0

High-throughput

0.232

Low

536052

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

0

High-throughput

0.232

Low

564788

ATN1
Sodium/potassium exporting P-type ATPase 1

1

0

High-throughput

0.232

Low

581816

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

585568

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.232

Low

672717

BPH1
Beige protein homolog 1

1

0

High-throughput

0.232

Low

713590

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.232

Low

744701

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

High-throughput

0.232

Low

744773

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.232

Low

754722

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

High-throughput

0.232

Low

758489

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.232

Low

778864

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.232

Low

779636

VPS21
Vacuolar protein sorting-associated protein 21

1

0

High-throughput

0.232

Low

782555

NU133
Nucleoporin NUP133

1

0

High-throughput

0.232

Low

784508

RM40
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.232

Low

790343

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.232

Low

792671

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.232

Low

793454

ATR
Serine/threonine-protein kinase MEC1

1

0

High-throughput

0.232

Low

795755

STU1
Protein STU1

1

0

High-throughput

0.232

Low

804954

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.232

Low

806853

MNL1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.232

Low

807142

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.232

Low

812179

FKHL1
Pre-rRNA-processing protein FHL1

1

0

High-throughput

0.232

Low

816132

AVT2
Vacuolar amino acid transporter 2

1

0

High-throughput

0.232

Low

816178

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.232

Low

817760

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.232

Low

820303

IES2
Ino eighty subunit 2

1

0

High-throughput

0.232

Low

825835

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.232

Low

826398

MPH1
ATP-dependent DNA helicase MPH1

1

0

High-throughput

0.232

Low

849949

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.232

Low

863591

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

High-throughput

0.232

Low

865847

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.232

Low

869463

GCST
Aminomethyltransferase, mitochondrial

1

0

High-throughput

0.232

Low

874342

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.232

Low

916532

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.232

Low

917268

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.232

Low

917403

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.232

Low

918399

FMP48
Probable serine/threonine-protein kinase FMP48

1

0

High-throughput

0.232

Low

918549

YG27
Putative uncharacterized protein YGR064W

1

0

High-throughput

0.232

Low

923201

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low

1018322

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.232

Low

1036922

MLP1
Protein MLP1

1

0

High-throughput

0.232

Low

1042689

PKH1
Serine/threonine-protein kinase PKH1

1

0

High-throughput

0.232

Low

1044294

VPS61
Putative uncharacterized protein VPS61

1

0

High-throughput

0.232

Low

1044887

UPS3
Protein UPS3, mitochondrial

1

0

High-throughput

0.232

Low

1046503

TAP42
Type 2A phosphatase-associated protein 42

1

0

High-throughput

0.232

Low

1046603

SPR28
Sporulation-regulated protein 28

1

0

High-throughput

0.232

Low

1046606

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.232

Low

1046607

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.232

Low

1046608

EAF1
Chromatin modification-related protein EAF1

1

0

High-throughput

0.232

Low

1046611

ALE1
Lysophospholipid acyltransferase

1

0

High-throughput

0.232

Low

1046612

ESA1
Histone acetyltransferase ESA1

1

0

High-throughput

0.232

Low

1046613

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

0

High-throughput

0.232

Low

1046614

EMC10
Endoplasmic reticulum membrane protein complex subunit 10

1

0

High-throughput

0.232

Low

1046615

UPPS
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.232

Low

1046616

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.232

Low

1046617

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.232

Low

1046618

AIM44
Altered inheritance of mitochondria protein 44

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025