Protein: LON
Lon protease (EC 3.4.21.53) (ATP-dependent protease La)

Gene: LON
Organism: Escherichia coli K-12
Interactions: 81
UniProt ID: P0A9M0

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004176 - ATP-dependent peptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445400

DPO3X
DNA polymerase III subunit tau

1

9

High-throughput

0.691

High

496887

LON
Lon protease

1

18

Small-scale

0.647

High

490333

HSLU
ATP-dependent protease ATPase subunit HslU

1

2

High-throughput

0.625

High

496892

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

11

High-throughput

0.618

High

493871

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.588

High

496888

RL13
Large ribosomal subunit protein uL13

2

1

High-throughput

0.588

High

496904

RLME
Ribosomal RNA large subunit methyltransferase E

2

1

High-throughput

0.588

High

496905

EFTU1
Elongation factor Tu 1

2

5

High-throughput

0.588

High

492126

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.586

High

496901

SECB
Protein-export protein SecB

2

0

High-throughput

0.585

High

496903

SSB
Single-stranded DNA-binding protein

2

2

High-throughput

0.571

High

489378

END4
Endonuclease 4

2

0

High-throughput

0.563

High

490870

HFQ
RNA-binding protein Hfq

2

0

High-throughput

0.563

High

493139

RL9
Large ribosomal subunit protein bL9

2

0

High-throughput

0.563

High

496899

RL21
Large ribosomal subunit protein bL21

2

0

High-throughput

0.563

High

496902

SRP54
Signal recognition particle protein

2

0

High-throughput

0.563

High

496915

CBPA
Curved DNA-binding protein

1

1

High-throughput

0.536

High

496917

ZNTA
Zinc/cadmium/lead-transporting P-type ATPase

1

3

High-throughput

0.536

High

496936

SUFS
Cysteine desulfurase

1

4

High-throughput

0.536

High

496939

YAJO
1-deoxyxylulose-5-phosphate synthase YajO

1

1

High-throughput

0.536

High

395072

DNAA
Chromosomal replication initiator protein DnaA

1

0

High-throughput

0.513

High

480535

GRPE
Protein GrpE

1

0

High-throughput

0.513

High

495709

CLPS
ATP-dependent Clp protease adapter protein ClpS

1

0

High-throughput

0.513

High

495799

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.513

High

496889

SAPF
Putrescine export system ATP-binding protein SapF

1

0

High-throughput

0.513

High

496896

ENTB
Enterobactin synthase component B

1

0

High-throughput

0.513

High

496898

SSPB
Stringent starvation protein B

1

0

High-throughput

0.513

High

496906

YBHB
UPF0098 protein YbhB

1

0

High-throughput

0.513

High

496907

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.513

High

496908

NADE
NH(3)-dependent NAD(+) synthetase

1

0

High-throughput

0.513

High

496910

WAAY
Lipopolysaccharide core heptose(II) kinase WaaY

1

0

High-throughput

0.513

High

496912

MOAD
Molybdopterin synthase sulfur carrier subunit

1

0

High-throughput

0.513

High

496929

YBJD
Uncharacterized protein YbjD

1

0

High-throughput

0.513

High

496932

PBPC
Penicillin-binding protein 1C

1

0

High-throughput

0.513

High

496934

CITC
[Citrate [pro-3S]-lyase] ligase

1

0

High-throughput

0.513

High

496935

LSRK
Autoinducer-2 kinase

1

0

High-throughput

0.513

High

496891

YBDG
Mechanosensing system component YbdG

1

1

High-throughput

0.489

High

496893

CYOA
Cytochrome bo(3) ubiquinol oxidase subunit 2

1

5

High-throughput

0.489

High

496909

NARY
Respiratory nitrate reductase 2 beta chain

1

1

High-throughput

0.489

High

496918

MSCM
Miniconductance mechanosensitive channel MscM

1

3

High-throughput

0.489

High

382666

RS7
Small ribosomal subunit protein uS7

1

1

High-throughput

0.484

High

444341

ERA
GTPase Era

1

5

High-throughput

0.484

High

489528

CH60
Chaperonin GroEL

1

5

High-throughput

0.484

High

490250

CLPP
ATP-dependent Clp protease proteolytic subunit

1

3

High-throughput

0.484

High

491029

DNAK
Chaperone protein DnaK

1

7

High-throughput

0.484

High

492821

RL20
Large ribosomal subunit protein bL20

1

1

High-throughput

0.484

High

493705

RS2
Small ribosomal subunit protein uS2

1

2

High-throughput

0.484

High

494369

RS8
Small ribosomal subunit protein uS8

1

3

High-throughput

0.484

High

496922

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.484

High

496937

DXS
1-deoxy-D-xylulose-5-phosphate synthase

1

1

High-throughput

0.484

High

496940

FSAA
Fructose-6-phosphate aldolase 1

1

1

High-throughput

0.484

High

490134

CH10
Co-chaperonin GroES

1

1

High-throughput

0.479

High

395109

DPO3E
DNA polymerase III subunit epsilon

1

0

High-throughput

0.464

High

490668

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

496894

DPS
DNA protection during starvation protein

1

0

High-throughput

0.464

High

496911

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.464

High

496916

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

496923

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.464

High

496926

FLAV
Flavodoxin 1

1

0

High-throughput

0.464

High

496941

UACR
Putative uric acid sigma-54-dependent transcriptional regulator UacR

1

0

High-throughput

0.464

High

492698

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

495555

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

496897

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

496919

YJGL
Uncharacterized protein YjgL

3

0

High-throughput

0.335

High

496921

UBIU
Ubiquinone biosynthesis protein UbiU

2

0

High-throughput

0.307

High

496913

TORA
Trimethylamine-N-oxide reductase 1

1

0

Small-scale

0.287

High

496928

PGAD
Biofilm PGA synthesis protein PgaD

1

0

High-throughput

0.282

High

494776

SMG
Protein Smg

1

0

High-throughput

0.279

Low

496890

ALLH
Oxamate carbamoyltransferase subunit AllH

1

0

High-throughput

0.279

Low

496895

FLGG
Flagellar basal-body rod protein FlgG

1

0

High-throughput

0.279

Low

496900

SUBI
Sulfate-binding protein

1

0

High-throughput

0.279

Low

496930

BLUF
Blue light- and temperature-regulated antirepressor BluF

1

0

High-throughput

0.279

Low

496931

YCJX
Ras-like GTPase YcjX

1

0

High-throughput

0.279

Low

496933

DJLC
Uncharacterized J domain-containing protein DjlC

1

0

High-throughput

0.279

Low

496938

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

0

High-throughput

0.279

Low

496927

YODC
Uncharacterized protein YodC

1

0

High-throughput

0.261

Low

496924

LOLA
Outer-membrane lipoprotein carrier protein

1

0

High-throughput

0.253

Low

496920

YJJU
Uncharacterized protein YjjU

1

0

High-throughput

0.249

Low

496925

LOLB
Outer-membrane lipoprotein LolB

1

0

High-throughput

0.249

Low

496914

YDBA
Exported protein YdbA

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025