Protein: MED6
Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6)

Gene: MED6
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P38782

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740403

MED17
Mediator of RNA polymerase II transcription subunit 17

20

0

Small-scale

0.938

High

797704

MED8
Mediator of RNA polymerase II transcription subunit 8

6

1

Small-scale

0.932

High

668486

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.887

High

740456

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.872

High

804032

MED10
Mediator of RNA polymerase II transcription subunit 10

3

4

Small-scale

0.843

High

401992

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

3

Small-scale

0.817

High

619426

MED14
Mediator of RNA polymerase II transcription subunit 14

9

3

Small-scale

0.749

High

804033

MED7
Mediator of RNA polymerase II transcription subunit 7

8

4

Small-scale

0.744

High

740794

MED18
Mediator of RNA polymerase II transcription subunit 18

10

0

Small-scale

0.720

High

801147

MED31
Mediator of RNA polymerase II transcription subunit 31

4

3

High-throughput

0.676

High

804023

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.670

High

448714

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.663

High

804029

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.657

High

804028

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.652

High

624908

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.649

High

804038

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.649

High

751206

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.648

High

757581

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

Small-scale

0.638

High

804037

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

High-throughput

0.634

High

804019

SSN3
Meiotic mRNA stability protein kinase SSN3

1

3

High-throughput

0.618

High

804034

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

800697

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.586

High

594355

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

804036

RIO1
Serine/threonine-protein kinase RIO1

2

1

High-throughput

0.571

High

707017

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

470522

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

626501

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

408410

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.480

High

804020

IFH1
Protein IFH1

1

0

Small-scale

0.480

High

804025

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.479

High

734420

BTAF1
TATA-binding protein-associated factor MOT1

1

2

Small-scale

0.479

High

804027

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

2

High-throughput

0.479

High

804021

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

733539

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

763318

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776564

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

804018

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

804035

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

804039

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

544776

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

804022

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

804031

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.445

High

804030

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.417

High

676836

DCC1
Sister chromatid cohesion protein DCC1

2

0

Small-scale

0.295

High

804024

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

675329

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.269

Low

796412

TRM7
tRNA

1

0

High-throughput

0.238

Low

804026

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025