Protein: PPB
Repressible alkaline phosphatase (EC 3.1.3.1) (Fructose-2,6-bisphosphate 6-phosphatase) (EC 3.1.3.54) (Membrane-bound repressible alkaline phosphatase) [Cleaved into: Soluble alkaline phosphatase (EC 3.1.7.6) (Farnesyl diphosphatase)]

Gene: PPB, PHO8
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P11491

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0004035 - alkaline phosphatase activity
GO:0009166 - nucleotide catabolic process
GO:0046496 - nicotinamide nucleotide metabolic process
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547022

PPB
Repressible alkaline phosphatase

1

4

Small-scale

0.618

High

547067

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.517

High

547023

BPT1
Bile pigment transporter 1

1

2

High-throughput

0.479

High

547026

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.479

High

547030

PHO91
Low-affinity phosphate transporter PHO91

1

1

High-throughput

0.479

High

547034

YBT1
ATP-dependent bile acid permease

1

2

High-throughput

0.479

High

547051

YCFI
Metal resistance protein YCF1

1

2

High-throughput

0.479

High

547055

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

Small-scale

0.479

High

547056

VTC1
Vacuolar transporter chaperone complex subunit 1

1

3

High-throughput

0.479

High

547058

SYG1
Protein SYG1

1

1

High-throughput

0.479

High

547060

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

1

High-throughput

0.479

High

547061

VTC2
Vacuolar transporter chaperone complex subunit 2

1

5

High-throughput

0.479

High

547063

VTC4
Vacuolar transporter chaperone complex subunit 4

1

5

High-throughput

0.479

High

547068

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

5

High-throughput

0.479

High

547070

RMD1
Sporulation protein RMD1

1

1

High-throughput

0.479

High

547078

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

1

High-throughput

0.479

High

547081

YPK9
Vacuolar cation-transporting ATPase YPK9

1

1

High-throughput

0.479

High

547082

VCX1
Vacuolar calcium ion transporter

1

1

High-throughput

0.479

High

547077

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.460

High

522860

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.458

High

547025

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.458

High

547028

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.458

High

547029

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

547032

VATC
V-type proton ATPase subunit C

1

0

High-throughput

0.458

High

547033

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.458

High

547035

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.458

High

547037

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

547038

COT1
Vacuolar zinc transporter COT1

1

0

High-throughput

0.458

High

547039

VATL2
V-type proton ATPase subunit c'

1

0

High-throughput

0.458

High

547044

ZRT3
Zinc-regulated transporter 3

1

0

High-throughput

0.458

High

547047

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.458

High

547050

VTC5
Vacuole transporter chaperone complex subunit 5

1

0

High-throughput

0.458

High

547053

KC13
Casein kinase I homolog 3

1

0

High-throughput

0.458

High

547054

VAC8
Vacuolar protein 8

1

0

High-throughput

0.458

High

547057

PPN2
Zinc-dependent endopolyphosphatase

1

0

Small-scale

0.458

High

547059

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.458

High

547064

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.458

High

547065

VOA1
V0 assembly protein 1

1

0

High-throughput

0.458

High

547066

VSB1
Vacuolar basic amino acid transporter VSB1

1

0

High-throughput

0.458

High

547076

SMF3
Iron transporter SMF3

1

0

High-throughput

0.458

High

547079

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.458

High

547080

YVC1
Calcium channel YVC1

1

0

High-throughput

0.458

High

510127

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.437

High

547031

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

547062

RMD8
Sporulation protein RMD8

1

1

High-throughput

0.437

High

547036

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.407

High

547049

SVP26
Protein SVP26

2

0

Small-scale

0.305

High

547027

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.279

Low

547074

AP3D
AP-3 complex subunit delta

1

0

Small-scale

0.261

Low

149540

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

409890

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433398

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

434755

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

441658

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

512770

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

547024

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

547040

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

547041

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

547042

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.249

Low

547043

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

547045

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

547046

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

547048

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

547052

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

547069

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

547071

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.249

Low

547072

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

547073

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

547075

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025