HitPredict

Interactor 1: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21822214
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~SH2, SH2~SH2, SH2~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0050853 - B cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 847
+	Hs
		548737 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		655500 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Gg
		1257382 BLNK_CHICK (1-456): 4.27e-37: 144: 38.41		Q8UUX6_CHICK (1-847): 0: 651: 86.19
+	Hs
		548645 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		548696 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		655471 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		ECT2_HUMAN (101-625): 2.68e-83: 287: 18.71
+	Hs
		655405 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		FGD2_HUMAN (95-577): 5.98e-82: 278: 14.23
+	Hs
		562659 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		581031 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Mm
		1208607 BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56		PLCG2_MOUSE (661-845): 2.07e-14: 79.7: 30.69
+	Hs
		924727 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		222321 O54737_MOUSE (1-444): 3.19e-60: 206: 58.22		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		562627 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580936 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		129269 P85B_HUMAN (129-453): 1.23e-44: 168: 17.05		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		655306 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		643091 P85A_MOUSE (121-453): 4.26e-43: 163: 14.41		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		580995 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924670 CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924534 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39