HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: K2C1B (Q7Z794)
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)
Gene: KRT77

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 35575683, unassigned1304
Identification Methods	two hybrid, cross-linking study, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 578
+	Hs
		407363 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C1_HUMAN (129-510): 2.72e-162: 479: 68.06
+	Hs
		475506 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C3_HUMAN (136-480): 1.68e-149: 446: 68.01
+	Hs
		437062 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C8_HUMAN (136-521): 2.31e-135: 404: 55.70
+	Hs
		475501 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C7_HUMAN (94-491): 1.86e-132: 396: 56.75
+	Hs
		341726 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C75_HUMAN (1-566): 5.19e-96: 305: 53.95
+	Hs
		475621 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C73_HUMAN (1-559): 9e-95: 301: 52.95
+	Hs
		475559 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT83_HUMAN (44-485): 3.6e-90: 288: 42.89
+	Hs
		475576 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT81_HUMAN (49-479): 1.37e-89: 287: 43.52
+	Hs
		227200 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT86_HUMAN (46-485): 1.37e-88: 284: 43.31
+	Hs
		475560 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT85_HUMAN (39-535): 1.52e-87: 282: 40.00
+	Hs
		475598 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C79_HUMAN (3-554): 4.26e-85: 276: 52.34
+	Hs
		475510 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C5_HUMAN (1-480): 3.6e-83: 272: 59.26
+	Hs
		475588 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C71_HUMAN (1-557): 1.54e-82: 269: 50.63
+	Hs
		407240 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6B_HUMAN (4-501): 2.56e-81: 267: 58.12
+	Hs
		475542 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6C_HUMAN (4-501): 3.09e-81: 267: 57.52
+	Hs
		385220 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6A_HUMAN (4-501): 1.36e-77: 257: 58.12
+	Hs
		475579 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C72_HUMAN (1-480): 4.23e-76: 252: 52.50
+	Hs
		475613 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C74_HUMAN (1-545): 1.27e-74: 248: 50.46
+	Hs
		475516 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C4_HUMAN (5-496): 5.67e-73: 244: 57.72
+	Hs
		475561 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K22O_HUMAN (1-492): 1.46e-67: 232: 55.06