Protein: CDSN
Corneodesmosin (S protein)

Gene: CDSN
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q15517

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0003336 - corneocyte desquamation
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1098190

MMRN1
Multimerin-1

3

0

High-throughput

0.638

High

584546

VAV
Proto-oncogene vav

2

0

High-throughput

0.602

High

1149547

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

2

High-throughput

0.536

High

1149503

CEP55
Centrosomal protein of 55 kDa

2

1

High-throughput

0.526

High

193579

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.513

High

358059

ADH1G
Alcohol dehydrogenase 1C

1

0

High-throughput

0.513

High

420252

IFNA4
Interferon alpha-4

1

0

High-throughput

0.513

High

722786

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

733355

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

943056

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1149508

JADE1
Protein Jade-1

1

0

High-throughput

0.513

High

1149525

OR2LD
Olfactory receptor 2L13

1

0

High-throughput

0.513

High

1149530

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

1149543

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

1149555

RAB9B
Ras-related protein Rab-9B

1

0

High-throughput

0.513

High

1149560

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.513

High

1149558

UBQL4
Ubiquilin-4

1

6

High-throughput

0.494

High

1123910

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.493

High

691032

1433T
14-3-3 protein theta

1

1

High-throughput

0.489

High

1149532

ZDH19
Palmitoyltransferase ZDHHC19

1

1

High-throughput

0.489

High

1149536

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.489

High

968633

NCS1
Neuronal calcium sensor 1

1

7

High-throughput

0.481

High

1009651

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.481

High

1085994

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.481

High

1149506

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

1

High-throughput

0.481

High

1149521

EXOC8
Exocyst complex component 8

1

1

High-throughput

0.481

High

1149551

ENKD1
Enkurin domain-containing protein 1

1

1

High-throughput

0.481

High

1149553

PARVG
Gamma-parvin

1

1

High-throughput

0.481

High

1149564

UBQL2
Ubiquilin-2

1

6

High-throughput

0.481

High

1149565

CTNA3
Catenin alpha-3

1

1

High-throughput

0.481

High

1149567

UBQL1
Ubiquilin-1

1

6

High-throughput

0.481

High

1149571

CSEN
Calsenilin

1

7

High-throughput

0.481

High

892104

KLK7
Kallikrein-7

1

0

Small-scale

0.480

High

1149500

CDSN
Corneodesmosin

1

0

Small-scale

0.480

High

714143

PML
Protein PML

1

1

High-throughput

0.479

High

1113184

CUL3
Cullin-3

1

1

High-throughput

0.479

High

400879

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

423657

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

456740

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

537208

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

563812

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

729563

CASPE
Caspase-14

1

0

High-throughput

0.458

High

908830

NEK2
Serine/threonine-protein kinase Nek2

1

0

Small-scale

0.458

High

951688

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1024592

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1064431

DSC1
Desmocollin-1

1

0

High-throughput

0.458

High

1149535

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1149541

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

1149556

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

839458

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

131436

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.439

High

169562

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.439

High

225593

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.439

High

226777

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

3

High-throughput

0.439

High

505565

ATX1L
Ataxin-1-like

1

1

High-throughput

0.439

High

750422

CSTF2
Cleavage stimulation factor subunit 2

1

3

High-throughput

0.439

High

856705

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.439

High

979412

VISL1
Visinin-like protein 1

1

7

High-throughput

0.439

High

1149507

DESI1
Desumoylating isopeptidase 1

1

1

High-throughput

0.439

High

1149515

TRI69
E3 ubiquitin-protein ligase TRIM69

1

1

High-throughput

0.439

High

1149518

NELFD
Negative elongation factor C/D

1

1

High-throughput

0.439

High

1149522

FAM9B
Protein FAM9B

1

1

High-throughput

0.439

High

1149527

BANP
Protein BANP

1

1

High-throughput

0.439

High

1149531

CCHCR
Coiled-coil alpha-helical rod protein 1

1

1

High-throughput

0.439

High

1149537

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

3

High-throughput

0.439

High

1149539

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.439

High

1149540

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

1

High-throughput

0.439

High

1149544

PLVAP
Plasmalemma vesicle-associated protein

1

1

High-throughput

0.439

High

1149548

TSG10
Testis-specific gene 10 protein

1

1

High-throughput

0.439

High

1149552

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

3

High-throughput

0.439

High

1149566

HPCL4
Hippocalcin-like protein 4

1

7

High-throughput

0.439

High

907441

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

990258

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.437

High

1114841

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

1137712

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.437

High

1149502

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

1149546

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

1149570

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

Small-scale

0.437

High

583555

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.426

High

626238

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

948839

CD81
CD81 antigen

1

0

Small-scale

0.426

High

1129809

EPN4
Clathrin interactor 1

1

0

High-throughput

0.426

High

1149526

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

943843

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.347

High

1149538

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

1149559

GPT2L
G patch domain-containing protein 2-like

2

0

High-throughput

0.328

High

1149516

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

185196

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.279

Low

325433

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.279

Low

602792

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.279

Low

666833

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

720117

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.279

Low

764229

CAH8
Carbonic anhydrase-related protein

1

0

High-throughput

0.279

Low

983656

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.279

Low

1071245

TMM62
Transmembrane protein 62

1

0

High-throughput

0.279

Low

1149501

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1149505

SPO16
Protein SPO16 homolog

1

0

High-throughput

0.279

Low

1149512

ZN550
Zinc finger protein 550

1

0

High-throughput

0.279

Low

1149514

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.279

Low

1149517

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.279

Low

1149519

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

1149523

D106A
Beta-defensin 106

1

0

High-throughput

0.279

Low

1149524

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.279

Low

1149528

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.279

Low

1149533

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.279

Low

1149534

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

0

High-throughput

0.279

Low

1149542

CHCH5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5

1

0

High-throughput

0.279

Low

1149554

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

1149557

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

1149562

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.279

Low

1149568

OAZ3
Ornithine decarboxylase antizyme 3

1

0

High-throughput

0.279

Low

1149573

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.261

Low

315623

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

372108

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

711641

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.249

Low

904757

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

970561

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1106906

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1118216

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.249

Low

1149510

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1149511

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1149513

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

1149545

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.249

Low

1149549

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.249

Low

1149550

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1149561

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1149563

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1149569

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.249

Low

1149572

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

87468

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

952184

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.232

Low

1086161

CETN1
Centrin-1

1

0

High-throughput

0.232

Low

1149504

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

1149509

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.232

Low

1149520

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

1149529

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025