Protein: UBE2S
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)

Gene: UBE2S
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q16763

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1086928

APC11
Anaphase-promoting complex subunit 11

31

20

Small-scale

0.993

High

475832

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

11

20

Small-scale

0.977

High

1086900

UBE2S
Ubiquitin-conjugating enzyme E2 S

9

15

Small-scale

0.977

High

607082

UBA1
Ubiquitin-like modifier-activating enzyme 1

8

20

Small-scale

0.965

High

1086945

FZR1
Fizzy-related protein homolog

5

8

Small-scale

0.933

High

1086942

ANC2
Anaphase-promoting complex subunit 2

4

18

Small-scale

0.901

High

1017389

CDC20
Cell division cycle protein 20 homolog

4

8

Small-scale

0.896

High

1086932

RBX2
RING-box protein 2

3

20

Small-scale

0.861

High

227592

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.768

High

1036277

BIRC2
Baculoviral IAP repeat-containing protein 2

2

20

Small-scale

0.767

High

475044

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.710

High

771991

VHL
von Hippel-Lindau disease tumor suppressor

4

4

Small-scale

0.708

High

672842

CDC27
Cell division cycle protein 27 homolog

5

4

Small-scale

0.704

High

1086922

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.698

High

256268

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

14

High-throughput

0.691

High

921584

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.665

High

1086938

CDC23
Cell division cycle protein 23 homolog

3

7

Small-scale

0.664

High

48113

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

20

Small-scale

0.647

High

800589

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

8

Small-scale

0.647

High

962806

MDM2
E3 ubiquitin-protein ligase Mdm2

1

15

Small-scale

0.647

High

1077999

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

20

Small-scale

0.647

High

1086902

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.647

High

1086904

OTU7B
OTU domain-containing protein 7B

1

7

Small-scale

0.647

High

1086918

OTUB1
Ubiquitin thioesterase OTUB1

1

12

Small-scale

0.647

High

1086909

IFTAP
Intraflagellar transport-associated protein

3

0

High-throughput

0.638

High

717125

CTNB1
Catenin beta-1

2

3

Small-scale

0.624

High

135937

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

17

Small-scale

0.618

High

282667

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.618

High

895799

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

16

Small-scale

0.618

High

908625

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

16

High-throughput

0.618

High

1029483

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.618

High

1086903

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

20

Small-scale

0.618

High

1086937

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

1086910

YAF2
YY1-associated factor 2

2

0

High-throughput

0.602

High

1086934

ZRAN1
Ubiquitin thioesterase ZRANB1

2

15

Small-scale

0.595

High

1086946

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

5

Small-scale

0.595

High

1086925

LRC4C
Leucine-rich repeat-containing protein 4C

2

1

High-throughput

0.574

High

639755

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.561

High

681877

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.561

High

890690

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.559

High

1086906

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

452796

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1086914

US6NL
USP6 N-terminal-like protein

1

2

High-throughput

0.536

High

1086920

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1086927

ING3
Inhibitor of growth protein 3

1

1

High-throughput

0.536

High

1086947

TNPO3
Transportin-3

1

1

High-throughput

0.528

High

1086911

CDK20
Cyclin-dependent kinase 20

1

4

High-throughput

0.515

High

801515

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.513

High

1086913

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1086921

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.513

High

1086933

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

1086944

FBX5
F-box only protein 5

1

0

Small-scale

0.513

High

271103

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.501

High

317730

STABP
STAM-binding protein

1

1

Small-scale

0.501

High

394803

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

868204

ATX3
Ataxin-3

1

1

Small-scale

0.501

High

1022904

CDC16
Cell division cycle protein 16 homolog

1

7

Small-scale

0.501

High

1086915

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.501

High

1086939

APC7
Anaphase-promoting complex subunit 7

1

4

Small-scale

0.501

High

1086943

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

Small-scale

0.501

High

1086908

MILR1
Allergin-1

1

3

High-throughput

0.489

High

1086919

LRC3B
Leucine-rich repeat-containing protein 3B

1

2

High-throughput

0.489

High

548104

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.480

High

1086923

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.480

High

1086926

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.480

High

1086940

APC5
Anaphase-promoting complex subunit 5

1

0

Small-scale

0.480

High

1086941

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.480

High

202189

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

2

Small-scale

0.479

High

244512

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

338491

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

502155

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

504152

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.479

High

523793

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

524942

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

552845

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

582316

NUCL
Nucleolin

1

3

Small-scale

0.479

High

651334

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

713987

HS71L
Heat shock 70 kDa protein 1-like

1

3

Small-scale

0.479

High

720585

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

790795

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

Small-scale

0.479

High

804128

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

3

Small-scale

0.479

High

824067

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

830372

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.479

High

874986

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

998780

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1035241

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

7

High-throughput

0.479

High

1086917

OPTN
Optineurin

1

5

High-throughput

0.479

High

1086935

SRP68
Signal recognition particle subunit SRP68

1

1

Small-scale

0.479

High

1086936

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

455499

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

1069247

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.458

High

1086905

PMF1
Polyamine-modulated factor 1

1

0

Small-scale

0.458

High

1086907

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1086929

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

Small-scale

0.458

High

1086930

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

Small-scale

0.458

High

1086931

DPM3
Dolichol-phosphate mannosyltransferase subunit 3

1

0

Small-scale

0.458

High

1086901

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1086924

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

529188

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

213124

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

1086916

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.279

Low

1086912

SVOPL
Putative transporter SVOPL

1

0

Small-scale

0.249

Low

283647

JTB
Protein JTB

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024