Protein: CCNK
Cyclin-K

Gene: CCNK
Organism: Homo sapiens
Interactions: 109
UniProt ID: O75909

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0002944 - cyclin K-CDK12 complex
GO:0002945 - cyclin K-CDK13 complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296988

CDK13
Cyclin-dependent kinase 13

7

20

Small-scale

0.968

High

297037

CDK12
Cyclin-dependent kinase 12

4

20

Small-scale

0.890

High

296985

CDK18
Cyclin-dependent kinase 18

3

20

High-throughput

0.861

High

296969

CDK9
Cyclin-dependent kinase 9

2

20

Small-scale

0.783

High

296986

TLE5
TLE family member 5

3

0

High-throughput

0.646

High

296971

ATX1
Ataxin-1

2

1

High-throughput

0.643

High

296948

MYC
Myc proto-oncogene protein

3

6

High-throughput

0.640

High

296983

RUNX1
Runt-related transcription factor 1

3

0

High-throughput

0.625

High

297021

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.618

High

296950

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.618

High

296981

CDK5
Cyclin-dependent kinase 5

1

20

High-throughput

0.618

High

180190

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

3

High-throughput

0.606

High

296954

MYCL
Protein L-Myc

2

6

High-throughput

0.606

High

296963

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

6

High-throughput

0.606

High

296967

HXA1
Homeobox protein Hox-A1

2

4

High-throughput

0.606

High

296972

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

2

5

High-throughput

0.606

High

296977

PO6F2
POU domain, class 6, transcription factor 2

2

4

High-throughput

0.606

High

297024

HSFY1
Heat shock transcription factor, Y-linked

2

1

High-throughput

0.606

High

297036

ZN446
Zinc finger protein 446

2

1

High-throughput

0.606

High

296994

DDB1
DNA damage-binding protein 1

2

6

Small-scale

0.602

High

296959

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

5

Small-scale

0.594

High

296982

CDK16
Cyclin-dependent kinase 16

1

20

Small-scale

0.590

High

163875

NDC80
Kinetochore protein NDC80 homolog

1

2

High-throughput

0.573

High

296949

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

297022

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

154923

BHE40
Class E basic helix-loop-helix protein 40

1

0

High-throughput

0.549

High

296992

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

297020

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

3

High-throughput

0.541

High

297028

RHXF2
Rhox homeobox family member 2

1

3

High-throughput

0.541

High

297032

HM20A
High mobility group protein 20A

1

6

High-throughput

0.541

High

297042

T22D4
TSC22 domain family protein 4

1

2

High-throughput

0.541

High

296960

1433T
14-3-3 protein theta

1

4

High-throughput

0.536

High

296962

RXRB
Retinoic acid receptor RXR-beta

1

17

High-throughput

0.536

High

296990

IMB1
Importin subunit beta-1

1

1

High-throughput

0.536

High

296991

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

297000

CDC73
Parafibromin

1

1

Small-scale

0.536

High

297029

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.523

High

297007

RFX6
DNA-binding protein RFX6

1

0

High-throughput

0.518

High

297019

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.515

High

297031

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

297001

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

Small-scale

0.500

High

297014

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

Small-scale

0.500

High

286606

STX11
Syntaxin-11

1

4

High-throughput

0.494

High

296947

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

1

High-throughput

0.494

High

297012

KCNRG
Potassium channel regulatory protein

1

3

High-throughput

0.494

High

297013

USBP1
Harmonin-binding protein USHBP1

1

2

High-throughput

0.494

High

297027

KR412
Keratin-associated protein 4-12

1

3

High-throughput

0.494

High

296956

ZEP1
Zinc finger protein 40

1

3

High-throughput

0.481

High

297009

HOMEZ
Homeobox and leucine zipper protein Homez

1

1

High-throughput

0.481

High

296974

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.480

High

296987

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.480

High

128679

MEN1
Menin

1

1

High-throughput

0.479

High

175817

SET1A
Histone-lysine N-methyltransferase SETD1A

1

4

Small-scale

0.479

High

240316

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

259228

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

296945

EYA4
Protein phosphatase EYA4

1

7

High-throughput

0.479

High

296946

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

High-throughput

0.479

High

296951

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

296952

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

296953

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

296955

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

296957

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

296961

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

296964

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

296965

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

296966

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

296968

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.479

High

296970

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

296973

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

296975

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

296980

VIGLN
Vigilin

1

2

High-throughput

0.479

High

296984

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

296989

DHX8
ATP-dependent RNA helicase DHX8

1

3

High-throughput

0.479

High

296993

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

297003

PAXI1
PAX-interacting protein 1

1

2

High-throughput

0.479

High

297006

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

297010

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

297017

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

297018

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

297026

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.479

High

297030

DDX23
Probable ATP-dependent RNA helicase DDX23

1

4

High-throughput

0.479

High

297034

RNC
Ribonuclease 3

1

5

High-throughput

0.479

High

297039

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

297041

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

296978

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

297023

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

297025

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

297035

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

296979

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

296976

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.437

High

296999

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

297002

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

297011

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

297033

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

3

High-throughput

0.437

High

297038

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

297040

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

50310

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

70059

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

296995

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

296996

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

296997

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

296998

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.316

High

297004

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

297008

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

297016

OXER1
Oxoeicosanoid receptor 1

2

0

High-throughput

0.316

High

276651

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

0

High-throughput

0.282

High

297015

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.282

High

297005

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.251

Low

296958

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025