Protein: NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59)

Gene: NUDT3
Organism: Homo sapiens
Interactions: 93
UniProt ID: O95989

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000298 - endopolyphosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

352719

NUD10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

1

5

High-throughput

0.691

High

352739

NUDT5
ADP-sugar pyrophosphatase

1

0

High-throughput

0.622

High

352665

RLA1
Large ribosomal subunit protein P1

2

0

High-throughput

0.594

High

352722

ASB13
Ankyrin repeat and SOCS box protein 13

2

0

High-throughput

0.594

High

352700

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.541

High

289236

SPB7
Serpin B7

1

4

High-throughput

0.536

High

352659

AACT
Alpha-1-antichymotrypsin

1

4

High-throughput

0.536

High

352663

APOD
Apolipoprotein D

1

1

High-throughput

0.536

High

352664

S10A8
Protein S100-A8

1

2

High-throughput

0.536

High

352666

S10A9
Protein S100-A9

1

4

High-throughput

0.536

High

352670

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.536

High

352671

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

352675

PLAK
Junction plakoglobin

1

1

High-throughput

0.536

High

352680

SPR1B
Cornifin-B

1

1

High-throughput

0.536

High

352687

SPB3
Serpin B3

1

4

High-throughput

0.536

High

352688

S10A7
Protein S100-A7

1

4

High-throughput

0.536

High

352691

SPR1A
Cornifin-A

1

1

High-throughput

0.536

High

352696

SPB4
Serpin B4

1

4

High-throughput

0.536

High

352713

FBX50
F-box only protein 50

1

1

High-throughput

0.536

High

352716

S1A7A
Protein S100-A7A

1

4

High-throughput

0.536

High

352725

CPNS2
Calpain small subunit 2

1

1

High-throughput

0.536

High

352738

SPB13
Serpin B13

1

4

High-throughput

0.536

High

325201

SOX30
Transcription factor SOX-30

1

0

High-throughput

0.518

High

352731

RAB17
Ras-related protein Rab-17

1

0

High-throughput

0.518

High

352723

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.515

High

161852

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.513

High

276552

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.513

High

352660

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

352662

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

352667

INVO
Involucrin

1

0

High-throughput

0.513

High

352676

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

352677

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

352678

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.513

High

352681

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

352682

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

352684

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

352699

AP1S2
AP-1 complex subunit sigma-2

1

0

High-throughput

0.513

High

352708

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

352710

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.513

High

352715

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.513

High

352718

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.513

High

352726

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

352727

SH3G3
Endophilin-A3

1

0

High-throughput

0.513

High

352732

RNAS7
Ribonuclease 7

1

0

High-throughput

0.513

High

352735

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.513

High

352672

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

1

High-throughput

0.508

High

352679

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.508

High

352689

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.508

High

352690

MCM5
DNA replication licensing factor MCM5

1

1

High-throughput

0.508

High

352705

HES1
Transcription factor HES-1

1

1

High-throughput

0.508

High

352711

WDR74
WD repeat-containing protein 74

1

4

High-throughput

0.508

High

352712

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.508

High

352736

GCP4
Gamma-tubulin complex component 4

1

1

High-throughput

0.508

High

261577

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

352686

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

352702

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

162304

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.486

High

317390

KPCD3
Serine/threonine-protein kinase D3

1

0

High-throughput

0.486

High

352661

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.486

High

352673

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.486

High

352683

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.486

High

352685

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.486

High

352692

TNNT3
Troponin T, fast skeletal muscle

1

0

High-throughput

0.486

High

352697

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.486

High

352707

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.486

High

352709

DREB
Drebrin

1

0

High-throughput

0.486

High

352714

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.486

High

352717

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.486

High

352728

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.486

High

352730

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

1

0

High-throughput

0.486

High

352733

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.486

High

352734

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.486

High

352737

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.486

High

352669

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.479

High

352701

TPM4
Tropomyosin alpha-4 chain

1

1

High-throughput

0.479

High

352704

DDR1
Epithelial discoidin domain-containing receptor 1

1

1

High-throughput

0.464

High

352720

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.464

High

287427

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

352668

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.445

High

352694

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.445

High

75644

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

352674

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.426

High

352693

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.426

High

352695

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.426

High

69464

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

352721

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

352729

ROGDI
Protein rogdi homolog

1

0

High-throughput

0.279

Low

352698

CCL11
Eotaxin

1

0

High-throughput

0.265

Low

352703

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.265

Low

352706

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.265

Low

352724

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low

352740

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.232

Low

352741

TMM98
Transmembrane protein 98

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025