Protein: SCD
Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase)

Gene: SCD
Organism: Homo sapiens
Interactions: 131
UniProt ID: O00767

Gene Ontology (top 5):
GO:0004768 - stearoyl-CoA 9-desaturase activity
GO:0005506 - iron ion binding
GO:0005730 - nucleolus
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

144392

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.611

High

144396

CXB1
Gap junction beta-1 protein

2

2

High-throughput

0.606

High

144440

MF14B
Hippocampus abundant transcript-like protein 1

2

1

High-throughput

0.606

High

144447

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

3

High-throughput

0.606

High

144476

RNF5
E3 ubiquitin-protein ligase RNF5

2

1

High-throughput

0.606

High

144503

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.606

High

144377

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.580

High

144401

PVR
Poliovirus receptor

2

0

High-throughput

0.580

High

144406

STOM
Stomatin

2

0

High-throughput

0.580

High

144415

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.580

High

144434

CC50B
Cell cycle control protein 50B

2

0

High-throughput

0.580

High

144435

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.580

High

144449

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.580

High

144453

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

144456

MCFD2
Multiple coagulation factor deficiency protein 2

2

0

High-throughput

0.580

High

144463

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

144468

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

144472

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

144477

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.580

High

144478

REEP2
Receptor expression-enhancing protein 2

2

0

High-throughput

0.580

High

144480

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.580

High

144491

CERS4
Ceramide synthase 4

2

0

High-throughput

0.580

High

144496

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.580

High

144497

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.580

High

144504

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

144391

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

144403

CD33
Myeloid cell surface antigen CD33

2

1

High-throughput

0.553

High

144428

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

144432

CL12B
C-type lectin domain family 12 member B

2

2

High-throughput

0.553

High

144458

S7A14
Solute carrier family 7 member 14

2

2

High-throughput

0.553

High

144460

GP152
Probable G-protein coupled receptor 152

2

2

High-throughput

0.553

High

144501

CLC4K
C-type lectin domain family 4 member K

2

1

High-throughput

0.553

High

129907

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

144378

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

144418

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.536

High

144462

PANK1
Pantothenate kinase 1

1

2

High-throughput

0.536

High

144479

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.536

High

144498

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

144393

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

144398

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

144408

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

144416

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

144459

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

144466

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

144487

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

144489

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

144494

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

144399

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

144446

UBE3B
Ubiquitin-protein ligase E3B

1

3

High-throughput

0.489

High

144482

PANK2
Pantothenate kinase 2, mitochondrial

1

2

High-throughput

0.489

High

144490

PANK3
Pantothenate kinase 3

1

2

High-throughput

0.489

High

144420

VMAT1
Chromaffin granule amine transporter

1

2

High-throughput

0.481

High

144395

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

144384

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

144389

RASN
GTPase NRas

1

2

High-throughput

0.479

High

144390

RASK
GTPase KRas

1

2

High-throughput

0.479

High

144394

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.479

High

144402

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

144421

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

144422

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

144423

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

144426

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

144427

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

144448

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

144454

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

144474

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

144485

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

144502

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.479

High

144382

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.458

High

144386

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

144387

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

144388

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

144409

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

144411

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

144424

H4
Histone H4

1

0

High-throughput

0.458

High

144429

CUL3
Cullin-3

1

0

High-throughput

0.458

High

144430

IRF4
Interferon regulatory factor 4

1

0

Small-scale

0.458

High

144436

MIDN
Midnolin

1

0

High-throughput

0.458

High

144444

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

144461

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

144475

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

144473

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

High-throughput

0.457

High

144495

S35C2
Solute carrier family 35 member C2

1

1

High-throughput

0.439

High

126358

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

144385

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

144397

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.437

High

144417

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.437

High

144419

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.437

High

144425

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

144431

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.437

High

144442

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

144445

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

144450

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

144465

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

144469

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

144481

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.437

High

144410

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.426

High

144414

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

144405

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

144437

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.407

High

144464

YLAT2
Y+L amino acid transporter 2

1

2

High-throughput

0.407

High

144379

TMPS2
Transmembrane protease serine 2

2

0

High-throughput

0.316

High

144412

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

144433

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.316

High

144486

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

144492

SPAG4
Sperm-associated antigen 4 protein

2

0

High-throughput

0.316

High

144493

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.316

High

144438

RHG15
Rho GTPase-activating protein 15

1

0

High-throughput

0.279

Low

144443

TTC27
Tetratricopeptide repeat protein 27

1

0

High-throughput

0.279

Low

144451

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

144483

ASXL3
Putative Polycomb group protein ASXL3

1

0

High-throughput

0.269

Low

144380

GPR42
G-protein coupled receptor 42

1

0

High-throughput

0.268

Low

144439

F209A
Protein FAM209A

1

0

High-throughput

0.251

Low

144381

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

144383

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

144413

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

144441

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

144452

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

144455

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.249

Low

144457

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

144467

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

144470

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

144471

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

144484

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

144488

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

144499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

144500

TES
Testin

1

0

High-throughput

0.249

Low

144505

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

144400

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

144404

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.232

Low

144407

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025