Protein: COX6
Cytochrome c oxidase subunit 6, mitochondrial (Cytochrome c oxidase polypeptide VI)

Gene: COX6
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: P00427

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0016491 - oxidoreductase activity
GO:0045277 - respiratory chain complex IV

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360623

COX2
Cytochrome c oxidase subunit 2

5

0

Small-scale

0.852

High

360760

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

1

High-throughput

0.754

High

360846

COX4
Cytochrome c oxidase subunit 4, mitochondrial

2

1

High-throughput

0.754

High

360894

MTC3
Maintenance of telomere capping protein 3, mitochondrial

2

0

High-throughput

0.716

High

360306

COX1
Cytochrome c oxidase subunit 1

5

1

Small-scale

0.699

High

360853

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

3

3

Small-scale

0.640

High

360813

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.618

High

360852

COX9
Cytochrome c oxidase subunit 9, mitochondrial

3

0

High-throughput

0.616

High

360735

COX3
Cytochrome c oxidase subunit 3

3

0

Small-scale

0.613

High

360879

MIC60
MICOS complex subunit MIC60

3

0

High-throughput

0.613

High

360865

ADT2
ADP,ATP carrier protein 2

2

2

Small-scale

0.611

High

360897

SHY1
Cytochrome oxidase assembly protein SHY1

2

1

Small-scale

0.611

High

360855

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

3

0

Small-scale

0.606

High

360850

CY1
Cytochrome c1, heme protein, mitochondrial

2

1

High-throughput

0.584

High

360892

TOM22
Mitochondrial import receptor subunit TOM22

2

0

High-throughput

0.559

High

360903

COX12
Cytochrome c oxidase subunit 12, mitochondrial

2

0

High-throughput

0.559

High

360898

RCF2
Respiratory supercomplex factor 2, mitochondrial

2

0

Small-scale

0.547

High

360900

ATP9
ATP synthase subunit 9, mitochondrial

2

0

Small-scale

0.547

High

360843

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

360845

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

360848

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.479

High

360849

ATPF
ATP synthase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

360851

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

360854

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.479

High

360857

ATPO
ATP synthase subunit 5, mitochondrial

1

1

High-throughput

0.479

High

360866

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

360872

ATP7
ATP synthase subunit d, mitochondrial

1

1

High-throughput

0.479

High

360875

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

1

High-throughput

0.479

High

360883

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

1

High-throughput

0.479

High

360885

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

1

High-throughput

0.479

High

360887

PHB1
Prohibitin-1

1

1

High-throughput

0.479

High

360893

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

360906

YHM2
Citrate/oxoglutarate carrier protein

1

2

High-throughput

0.479

High

360907

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

357742

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.458

High

357792

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.458

High

360844

ATP6
ATP synthase subunit a

1

0

Small-scale

0.458

High

360847

COX8
Cytochrome c oxidase subunit 8, mitochondrial

1

0

High-throughput

0.458

High

360856

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

0

High-throughput

0.458

High

360858

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.458

High

360860

COX7
Cytochrome c oxidase subunit 7, mitochondrial

1

0

High-throughput

0.458

High

360864

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

360867

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.458

High

360868

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

360870

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

360873

MSS51
Protein MSS51, mitochondrial

1

0

Small-scale

0.458

High

360876

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

360877

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

360880

QCR10
Cytochrome b-c1 complex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

360881

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

360884

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

360890

COX16
Cytochrome c oxidase assembly protein COX16, mitochondrial

1

0

Small-scale

0.458

High

360891

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.458

High

360895

GEP7
Genetic interactor of prohibitin 7, mitochondrial

1

0

High-throughput

0.458

High

360896

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.458

High

360899

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

360902

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

360908

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.458

High

360909

YD157
Uncharacterized protein YDL157C, mitochondrial

1

0

Small-scale

0.458

High

360910

COA3
Cytochrome c oxidase assembly factor 3, mitochondrial

1

0

Small-scale

0.458

High

360862

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

357872

CYB
Cytochrome b

1

0

Small-scale

0.426

High

360905

RCF1
Respiratory supercomplex factor 1, mitochondrial

1

0

Small-scale

0.426

High

360904

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.417

High

360861

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

360869

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

360874

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

360888

NOP2
25S rRNA

1

0

High-throughput

0.279

Low

64205

YP010
UPF0495 protein YPR010C-A

1

0

Small-scale

0.249

Low

360859

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

360871

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

360878

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

360882

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

360886

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

360889

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

360901

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.249

Low

360863

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025