Protein: ILV5
Ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Isoleucine-plus-valine requiring protein 5)

Gene: ILV5
Organism: Saccharomyces cerevisiae S288C
Interactions: 138
UniProt ID: P06168

Gene Ontology (top 5):
GO:0003690 - double-stranded DNA binding
GO:0004455 - ketol-acid reductoisomerase activity
GO:0005739 - mitochondrion
GO:0009082 - branched-chain amino acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439055

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

2

High-throughput

0.618

High

439076

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

439064

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

2

0

High-throughput

0.559

High

439070

HSP77
Import motor subunit, mitochondrial

2

0

High-throughput

0.559

High

439081

MDHM
Malate dehydrogenase, mitochondrial

2

0

Small-scale

0.559

High

439127

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

2

0

Small-scale

0.559

High

439148

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

439058

SIR3
Regulatory protein SIR3

1

1

High-throughput

0.536

High

439159

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

439106

HS104
Heat shock protein 104

2

1

Small-scale

0.533

High

391987

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.521

High

439074

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

0

High-throughput

0.513

High

439094

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.513

High

439158

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

368105

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.493

High

439087

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.479

High

439096

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.479

High

439109

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.479

High

439154

RHO5
GTP-binding protein RHO5

1

0

High-throughput

0.479

High

366870

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

439060

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

439061

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.479

High

439083

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

439089

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

439114

YPT7
Ypt/Rab-type GTPase YPT7

1

1

Small-scale

0.479

High

439117

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

439157

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

439168

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.479

High

358930

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.458

High

367846

ENO2
Enolase 2

1

0

High-throughput

0.458

High

370489

STF1
F(1)-ATPase inhibitor STF1, mitochondrial

1

0

High-throughput

0.458

High

394009

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

416332

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

416979

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.458

High

439059

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

439066

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

439067

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

439072

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

439077

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

439082

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

439086

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.458

High

439090

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

439092

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

439093

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

439099

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

439100

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

439102

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

439103

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.458

High

439108

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

439111

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

439112

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.458

High

439119

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

439121

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.458

High

439135

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

439139

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.458

High

439140

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

439142

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.458

High

439144

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

439146

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

439152

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

439153

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

439156

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

439137

ACON2
Homocitrate dehydratase, mitochondrial

1

1

High-throughput

0.445

High

439104

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

439105

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

439164

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

439176

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

439177

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

439143

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.426

High

439155

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.426

High

439095

SIS1
Protein SIS1

2

0

High-throughput

0.313

High

439132

TCPD
T-complex protein 1 subunit delta

2

0

High-throughput

0.298

High

439088

NUP1
Nucleoporin NUP1

1

0

High-throughput

0.279

Low

439116

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

0

High-throughput

0.279

Low

439120

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

439128

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

439138

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.279

Low

439165

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.279

Low

439056

KAPB
cAMP-dependent protein kinase type 2

1

0

High-throughput

0.261

Low

439065

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

439073

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.261

Low

439075

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.261

Low

439080

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.261

Low

439084

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.261

Low

439085

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

439107

CDC3
Cell division control protein 3

1

0

High-throughput

0.261

Low

439110

CDC13
Cell division control protein 13

1

0

High-throughput

0.261

Low

439113

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

439124

IMB2
Importin subunit beta-2

1

0

High-throughput

0.261

Low

439130

DUN1
DNA damage response protein kinase DUN1

1

0

High-throughput

0.261

Low

439131

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.261

Low

439133

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.261

Low

439145

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.261

Low

439174

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.261

Low

439175

ATG5
Autophagy protein 5

1

0

High-throughput

0.261

Low

439179

AP2M
AP-2 complex subunit mu

1

0

High-throughput

0.261

Low

432265

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.249

Low

433338

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

434682

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

439057

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

439062

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.249

Low

439063

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

439068

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

439069

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

439071

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

439091

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

439097

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

439098

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

439101

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

439115

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

439118

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

439122

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

439123

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.249

Low

439125

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

439126

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

439129

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

439134

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

439136

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

439147

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

439150

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

439151

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

439160

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

439161

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.249

Low

439162

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

439163

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.249

Low

439166

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

439167

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

439169

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

439170

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

439171

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

439173

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

439078

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.232

Low

439079

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

439141

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.232

Low

439149

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

439172

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low

439178

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025