Protein: GGCT
Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21)

Gene: GGCT
Organism: Homo sapiens
Interactions: 56
UniProt ID: O75223

Gene Ontology (top 5):
GO:0001836 - release of cytochrome c from mitochondria
GO:0003839 - gamma-glutamylcyclotransferase activity
GO:0005829 - cytosol
GO:0042803 - protein homodimerization activity
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275162

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.585

High

66472

RASFA
Ras association domain-containing protein 10

1

1

High-throughput

0.536

High

275152

RASF9
Ras association domain-containing protein 9

1

2

High-throughput

0.536

High

275168

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

275169

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

275158

RASK
GTPase KRas

1

0

High-throughput

0.513

High

275166

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.513

High

275173

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.513

High

275191

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

275184

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.493

High

275171

RASF7
Ras association domain-containing protein 7

1

2

High-throughput

0.489

High

275159

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

275153

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

275160

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

275161

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

275163

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

275167

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

275170

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

275172

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.458

High

275175

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

275177

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

275178

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

275180

SMBT2
Scm-like with four MBT domains protein 2

1

0

High-throughput

0.458

High

275183

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

275187

OPTN
Optineurin

1

0

High-throughput

0.458

High

275189

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

275192

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

275193

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

275194

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

275199

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

275202

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

275156

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.426

High

275164

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

275174

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.426

High

275179

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

275181

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

275188

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.426

High

275157

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.305

High

275201

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.279

Low

275203

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.279

Low

275151

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

275154

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

275155

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

275165

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

275176

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

275182

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

275185

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

275186

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

275190

MTEF1
Transcription termination factor 1, mitochondrial

1

0

High-throughput

0.249

Low

275195

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.249

Low

275196

RNF38
E3 ubiquitin-protein ligase RNF38

1

0

Small-scale

0.249

Low

275197

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

275198

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

275200

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

275204

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

275205

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025