Protein: SAP3
Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]

Gene: SAP3, GM2A
Organism: Homo sapiens
Interactions: 73
UniProt ID: P17900

Gene Ontology (top 5):
GO:0005319 - lipid transporter activity
GO:0005576 - extracellular region
GO:0005829 - cytosol
GO:0006689 - ganglioside catabolic process
GO:0006869 - lipid transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338679

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

609303

ACTA
Actin, aortic smooth muscle

2

0

High-throughput

0.585

High

609301

CF298
Cilia- and flagella-associated protein 298

2

0

High-throughput

0.585

High

609345

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

222351

TSN6
Tetraspanin-6

1

0

High-throughput

0.513

High

292542

RENR
Renin receptor

1

0

High-throughput

0.513

High

348350

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.513

High

352678

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

391560

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

609297

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

609299

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

609332

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

609333

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

609337

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

609340

KLH11
Kelch-like protein 11

1

0

High-throughput

0.513

High

609341

GID8
Glucose-induced degradation protein 8 homolog

1

0

High-throughput

0.513

High

609304

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.493

High

552117

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

484904

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

555860

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

609293

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

406959

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.426

High

449558

HEXA
Beta-hexosaminidase subunit alpha

1

0

Small-scale

0.426

High

536457

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

609302

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

609307

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

609321

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.426

High

609344

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.407

High

609308

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

0

High-throughput

0.347

High

609322

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

609331

SSBP4
Single-stranded DNA-binding protein 4

3

0

High-throughput

0.347

High

231100

AIRE
Autoimmune regulator

2

0

High-throughput

0.328

High

609309

SF3A1
Splicing factor 3A subunit 1

2

0

High-throughput

0.328

High

609310

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.328

High

609316

POC5
Centrosomal protein POC5

2

0

High-throughput

0.328

High

609335

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.328

High

609339

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

609305

HSF2
Heat shock factor protein 2

2

0

High-throughput

0.318

High

609312

MYOME
Myomegalin

2

0

High-throughput

0.318

High

609323

GMCL1
Germ cell-less protein-like 1

2

0

High-throughput

0.318

High

609324

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

135772

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

325277

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

609292

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.279

Low

609294

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

609295

HXD3
Homeobox protein Hox-D3

1

0

High-throughput

0.279

Low

609296

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

609298

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

609300

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

609306

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

609311

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

609314

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

609315

CERS3
Ceramide synthase 3

1

0

High-throughput

0.279

Low

609317

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

609318

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

609319

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.279

Low

609320

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

609325

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

609327

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

609328

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.279

Low

609329

SH23A
SH2 domain-containing protein 3A

1

0

High-throughput

0.279

Low

609336

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

609338

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

609342

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.279

Low

609343

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

609346

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

217805

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

293167

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

609330

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.249

Low

609334

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

261079

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

609313

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.232

Low

609326

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025