Protein: ARPC4
Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)

Gene: ARPC4
Organism: Homo sapiens
Interactions: 136
UniProt ID: P59998

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005885 - Arp2/3 protein complex
GO:0019899 - enzyme binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

887492

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

10

5

Small-scale

0.976

High

168761

ARC1B
Actin-related protein 2/3 complex subunit 1B

7

5

Small-scale

0.968

High

181308

ARPC5
Actin-related protein 2/3 complex subunit 5

8

5

Small-scale

0.966

High

887507

ARP3B
Actin-related protein 3B

5

7

High-throughput

0.932

High

887447

ARP2
Actin-related protein 2

5

6

High-throughput

0.930

High

168906

ARPC2
Actin-related protein 2/3 complex subunit 2

5

3

Small-scale

0.928

High

887446

ARP3
Actin-related protein 3

4

7

Small-scale

0.900

High

887486

ARC1A
Actin-related protein 2/3 complex subunit 1A

3

5

Small-scale

0.871

High

169058

ARPC3
Actin-related protein 2/3 complex subunit 3

7

3

Small-scale

0.749

High

887444

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.691

High

887502

ANLN
Anillin

3

0

High-throughput

0.628

High

528857

CFTR
Cystic fibrosis transmembrane conductance regulator

3

0

High-throughput

0.622

High

887451

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.618

High

887461

SRC8
Src substrate cortactin

2

1

Small-scale

0.611

High

126925

WASL
Actin nucleation-promoting factor WASL

2

3

High-throughput

0.606

High

496675

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

887482

MT21A
Protein N-lysine methyltransferase METTL21A

2

0

High-throughput

0.580

High

596385

RASA1
Ras GTPase-activating protein 1

2

2

High-throughput

0.571

High

227010

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

322395

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

346362

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

887494

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

261095

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

598028

FLNA
Filamin-A

1

1

High-throughput

0.536

High

790651

WASP
Actin nucleation-promoting factor WAS

1

4

Small-scale

0.536

High

809230

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

812975

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

813283

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

887453

CALD1
Caldesmon

1

2

High-throughput

0.536

High

887484

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.536

High

887489

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.536

High

887476

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.518

High

211546

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

362984

FINC
Fibronectin

1

0

High-throughput

0.513

High

440443

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

724735

MYH9
Myosin-9

1

0

High-throughput

0.513

High

862014

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

887448

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.513

High

887455

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

887460

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

887466

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

887468

DREB
Drebrin

1

0

High-throughput

0.513

High

887477

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

887503

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

887504

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

887508

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

328788

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.493

High

833699

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.480

High

301702

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

308548

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

501891

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

841597

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

887459

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

887463

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

887469

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

887473

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.479

High

887475

ZN547
Zinc finger protein 547

1

1

High-throughput

0.479

High

887491

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

887493

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

887496

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

887511

DUX4
Double homeobox protein 4

1

1

High-throughput

0.479

High

887513

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

887516

TTLL3
Tubulin monoglycylase TTLL3

1

1

High-throughput

0.479

High

525885

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.470

High

128086

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

162561

XPO1
Exportin-1

1

0

High-throughput

0.458

High

167878

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

233322

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

294596

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

364219

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

373964

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

450789

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

503783

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

530540

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

552370

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

590754

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

632232

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

650815

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714944

PROF2
Profilin-2

1

0

High-throughput

0.458

High

720102

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

742172

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

779119

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

785799

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

786295

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.458

High

817847

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

832281

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

870717

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

887445

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

887449

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

887454

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

887456

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

887458

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

887464

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

887465

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

887467

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

887478

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

887481

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

Small-scale

0.458

High

887485

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

887487

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

887495

RHBT2
Rho-related BTB domain-containing protein 2

1

0

High-throughput

0.458

High

887498

SIK2
Serine/threonine-protein kinase SIK2

1

0

Small-scale

0.458

High

887500

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

887501

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

887509

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

887510

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

887512

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

717608

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

846592

INSL3
Insulin-like 3

1

1

High-throughput

0.437

High

887452

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

887472

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

887483

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

887497

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

887499

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

401725

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

484090

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

484542

TBA3D
Tubulin alpha-3D chain

1

0

High-throughput

0.426

High

581585

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

887450

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

887457

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

887514

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

887490

PNMA5
Paraneoplastic antigen-like protein 5

4

0

High-throughput

0.364

High

151296

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.279

Low

887479

CHUR
Protein Churchill

1

0

High-throughput

0.279

Low

887480

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

High-throughput

0.279

Low

887488

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

887505

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

329556

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

239542

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

823774

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

887462

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

887470

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

887471

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

887506

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

887515

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.249

Low

887474

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.238

Low

239885

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024