Protein: LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81)

Gene: LRCH1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9Y2L9

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0034260 - negative regulation of GTPase activity
GO:1990869 - cellular response to chemokine
GO:2000405 - negative regulation of T cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1394210

LRCH3
DISP complex protein LRCH3

4

18

High-throughput

0.900

High

1338529

DOCK8
Dedicator of cytokinesis protein 8

8

12

High-throughput

0.751

High

692844

CALL3
Calmodulin-like protein 3

1

20

High-throughput

0.691

High

1251229

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

20

High-throughput

0.691

High

1398868

DOCK7
Dedicator of cytokinesis protein 7

7

12

High-throughput

0.682

High

972162

1433E
14-3-3 protein epsilon

3

10

High-throughput

0.650

High

1273135

MOB1B
MOB kinase activator 1B

2

5

High-throughput

0.621

High

1393347

DOCK6
Dedicator of cytokinesis protein 6

4

12

High-throughput

0.619

High

281545

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

18

High-throughput

0.618

High

1218321

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

20

High-throughput

0.618

High

1353683

LRC15
Leucine-rich repeat-containing protein 15

1

19

High-throughput

0.618

High

955770

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

1116156

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.618

High

1256173

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1436462

MOB1A
MOB kinase activator 1A

2

5

High-throughput

0.611

High

1461984

MYO6
Unconventional myosin-VI

2

7

High-throughput

0.611

High

1461060

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.590

High

516608

CALM3
Calmodulin-3

1

20

High-throughput

0.575

High

1449821

TM14B
Transmembrane protein 14B

2

2

High-throughput

0.553

High

1490819

TM14A
Transmembrane protein 14A

2

2

High-throughput

0.553

High

412846

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

710584

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

1490818

SGT1
Protein SGT1 homolog

2

20

High-throughput

0.549

High

136018

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.536

High

571012

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

990897

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1054673

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.536

High

1435480

EGLN3
Prolyl hydroxylase EGLN3

1

7

High-throughput

0.536

High

1014668

SMAD3
Mothers against decapentaplegic homolog 3

1

12

Small-scale

0.515

High

516735

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

5

High-throughput

0.514

High

61155

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.513

High

573915

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.513

High

754606

S10A3
Protein S100-A3

1

3

High-throughput

0.489

High

857602

NOTC1
Neurogenic locus notch homolog protein 1

1

6

High-throughput

0.489

High

1043246

TAP2
Antigen peptide transporter 2

1

2

High-throughput

0.489

High

1052128

CALD1
Caldesmon

1

6

High-throughput

0.489

High

1120995

TRI29
Tripartite motif-containing protein 29

1

6

High-throughput

0.489

High

1251763

CERS6
Ceramide synthase 6

1

2

High-throughput

0.489

High

1286486

DSG4
Desmoglein-4

1

6

High-throughput

0.489

High

1372424

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.489

High

1450102

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

2

High-throughput

0.489

High

173583

XPO1
Exportin-1

1

7

High-throughput

0.479

High

831678

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

986827

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1005263

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1141072

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

1404849

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

1459371

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1460316

XPO7
Exportin-7

1

7

High-throughput

0.479

High

935321

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

1338081

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.445

High

76592

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

19

High-throughput

0.437

High

279543

TULP3
Tubby-related protein 3

1

2

High-throughput

0.437

High

590073

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

696910

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

905308

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

1367634

ESR2
Estrogen receptor beta

1

14

High-throughput

0.437

High

1447466

ANLN
Anillin

1

6

High-throughput

0.437

High

1439510

S10AE
Protein S100-A14

1

3

High-throughput

0.407

High

326800

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

1098691

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1207494

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

1236053

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

1286417

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

1450860

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.279

Low

1383419

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low

839644

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

1211090

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low

1358603

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025