Protein: TIGIT
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)

Gene: TIGIT
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q495A1

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0032695 - negative regulation of interleukin-12 production
GO:0032733 - positive regulation of interleukin-10 production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1193158

NECT2
Nectin-2

3

3

Small-scale

0.879

High

580780

PVR
Poliovirus receptor

3

3

Small-scale

0.865

High

1193161

NECT4
Nectin-4

1

3

Small-scale

0.724

High

1193164

NECT3
Nectin-3

1

4

Small-scale

0.724

High

522676

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

High-throughput

0.691

High

658889

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

1

High-throughput

0.691

High

690091

AVR2A
Activin receptor type-2A

1

1

High-throughput

0.691

High

787303

ACV1B
Activin receptor type-1B

1

1

High-throughput

0.691

High

1193151

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

Small-scale

0.687

High

1153390

CD226
CD226 antigen

1

5

Small-scale

0.665

High

1006906

KC1G2
Casein kinase I isoform gamma-2

1

0

High-throughput

0.656

High

1023430

AT8B2
Phospholipid-transporting ATPase ID

1

0

High-throughput

0.656

High

1062982

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

High-throughput

0.656

High

1193160

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

0

High-throughput

0.656

High

1193166

PLLP
Plasmolipin

2

1

High-throughput

0.606

High

732613

ARRB2
Beta-arrestin-2

1

0

Small-scale

0.586

High

1193159

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.586

High

322730

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.578

High

1193152

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

0

High-throughput

0.578

High

1193154

RSLBA
Ras-like protein family member 11A

1

0

High-throughput

0.578

High

636222

MAL
Myelin and lymphocyte protein

2

1

High-throughput

0.553

High

1193157

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

71333

F1712
Protein FAM171A2

1

0

High-throughput

0.279

Low

1193153

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.279

Low

1193155

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low

1193156

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1193162

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.279

Low

1193163

ZDHC6
Palmitoyltransferase ZDHHC6

1

0

High-throughput

0.279

Low

1193165

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025