Protein: RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)

Gene: RUBIC, RUBCN
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q92622

Gene Ontology (top 5):
GO:0002376 - immune system process
GO:0005654 - nucleoplasm
GO:0005764 - lysosome
GO:0005769 - early endosome
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1126730

BECN1
Beclin-1

21

3

Small-scale

0.765

High

1365941

UVRAG
UV radiation resistance-associated gene protein

11

1

Small-scale

0.759

High

1337299

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

9

1

Small-scale

0.756

High

1365936

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

4

1

Small-scale

0.683

High

901980

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.618

High

363657

EGFR
Epidermal growth factor receptor

3

0

Small-scale

0.606

High

1365932

REQU
Zinc finger protein ubi-d4

2

1

High-throughput

0.606

High

966694

1433G
14-3-3 protein gamma

2

10

High-throughput

0.601

High

1049633

1433F
14-3-3 protein eta

2

10

High-throughput

0.601

High

631385

RAB5A
Ras-related protein Rab-5A

1

0

Small-scale

0.586

High

353722

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

1118941

BYST
Bystin

2

0

High-throughput

0.580

High

1120690

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.580

High

1185299

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1316951

FAM9B
Protein FAM9B

2

0

High-throughput

0.580

High

1365944

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

1213239

ZN648
Zinc finger protein 648

2

1

High-throughput

0.553

High

562806

CY24A
Cytochrome b-245 light chain

2

1

Small-scale

0.549

High

1365933

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

Small-scale

0.537

High

990564

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.536

High

1228880

ZFY26
Zinc finger FYVE domain-containing protein 26

1

2

High-throughput

0.536

High

416967

CY24B
NADPH oxidase 2

2

1

Small-scale

0.533

High

1365940

EXOC1
Exocyst complex component 1

1

0

Small-scale

0.529

High

943397

H2BFS
Histone H2B type F-S

1

1

High-throughput

0.515

High

1208862

H2B2F
Histone H2B type 2-F

1

1

High-throughput

0.515

High

1140120

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1365935

SPT33
Spermatogenesis-associated protein 33

1

0

High-throughput

0.513

High

1365945

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1365937

ZFY21
Zinc finger FYVE domain-containing protein 21

1

2

Small-scale

0.512

High

1365943

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.501

High

1291555

HOOK3
Protein Hook homolog 3

1

1

High-throughput

0.489

High

1365942

HOOK1
Protein Hook homolog 1

1

1

High-throughput

0.489

High

1247959

ANR11
Ankyrin repeat domain-containing protein 11

1

1

High-throughput

0.481

High

71498

BECN2
Beclin-2

1

3

Small-scale

0.479

High

562280

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

730111

1433B
14-3-3 protein beta/alpha

1

10

Small-scale

0.479

High

839331

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.479

High

971842

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

1365947

X5D778
Ankyrin repeat domain 11 isoform A

1

1

High-throughput

0.470

High

223227

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

272721

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.458

High

712881

CASP1
Caspase-1

1

0

Small-scale

0.458

High

1093281

FLII
Protein flightless-1 homolog

1

0

Small-scale

0.458

High

1252915

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

Small-scale

0.458

High

1276259

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1280171

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

Small-scale

0.458

High

1315108

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.458

High

1365934

EXOC2
Exocyst complex component 2

1

0

Small-scale

0.458

High

1365939

CARD9
Caspase recruitment domain-containing protein 9

1

0

Small-scale

0.458

High

1365946

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.458

High

342276

BRD1
Bromodomain-containing protein 1

2

0

High-throughput

0.316

High

585077

ZN250
Zinc finger protein 250

2

0

High-throughput

0.316

High

1331076

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

1365938

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1257281

STXB4
Syntaxin-binding protein 4

1

0

High-throughput

0.279

Low

566779

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025