Protein: FAN1
Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)

Gene: FAN1
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q9Y2M0

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000724 - double-strand break repair via homologous recombination
GO:0004528 - phosphodiesterase I activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1490820

FAN1
Fanconi-associated nuclease 1

3

0

Small-scale

0.809

High

827526

MLH1
DNA mismatch repair protein Mlh1

11

6

Small-scale

0.755

High

928725

PMS2
Mismatch repair endonuclease PMS2

7

6

Small-scale

0.743

High

928674

PMS1
PMS1 protein homolog 1

5

6

Small-scale

0.714

High

1417531

FACD2
Fanconi anemia group D2 protein

6

0

Small-scale

0.693

High

551347

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.598

High

1435904

ZN703
Zinc finger protein 703

2

0

High-throughput

0.585

High

508864

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

0

Small-scale

0.569

High

1450563

FANCI
Fanconi anemia group I protein

2

0

Small-scale

0.559

High

128086

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.513

High

130661

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

217296

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

323806

AP2A2
AP-2 complex subunit alpha-2

1

0

High-throughput

0.513

High

346751

CAVN2
Caveolae-associated protein 2

1

0

High-throughput

0.513

High

449584

HEXA
Beta-hexosaminidase subunit alpha

1

0

High-throughput

0.513

High

1032447

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1090595

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.513

High

1109247

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.513

High

1309722

WDR75
WD repeat-containing protein 75

1

0

High-throughput

0.513

High

1322550

MIER1
Mesoderm induction early response protein 1

1

0

High-throughput

0.513

High

1329584

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.513

High

1394735

PKHA8
Pleckstrin homology domain-containing family A member 8

1

0

High-throughput

0.513

High

1438845

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.513

High

926439

BLM
RecQ-like DNA helicase BLM

1

0

Small-scale

0.493

High

144029

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

1

High-throughput

0.479

High

628032

ANXA7
Annexin A7

1

1

High-throughput

0.479

High

718053

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.479

High

769809

RFC4
Replication factor C subunit 4

1

1

Small-scale

0.479

High

829292

RFC3
Replication factor C subunit 3

1

1

Small-scale

0.479

High

990898

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

1239492

H3C
Histone H3.3C

1

1

High-throughput

0.479

High

1459792

MLH3
DNA mismatch repair protein Mlh3

1

6

Small-scale

0.479

High

185252

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.458

High

214078

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.458

High

431281

LA
Lupus La protein

1

0

High-throughput

0.458

High

841503

RBM34
RNA-binding protein 34

1

0

High-throughput

0.458

High

925996

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

972163

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

1134438

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1240523

DHX57
Putative ATP-dependent RNA helicase DHX57

1

0

High-throughput

0.458

High

1281645

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1292983

AROS
Active regulator of SIRT1

1

0

High-throughput

0.458

High

1347121

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.458

High

1357071

FBLI1
Filamin-binding LIM protein 1

1

0

High-throughput

0.458

High

1380791

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1387367

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.458

High

1460317

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1462542

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

1490821

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

104003

F5GWN5
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

1

1

High-throughput

0.445

High

998968

H31
Histone H3.1

1

1

High-throughput

0.445

High

1161088

FSCN1
Fascin

1

0

Small-scale

0.426

High

76397

B4DT77
Annexin

1

1

High-throughput

0.407

High

91608

C9J9C1
Protein phosphatase 2 scaffold subunit Aalpha

1

1

High-throughput

0.407

High

733472

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.282

High

1294032

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

1350303

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.279

Low

1453410

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.249

Low

947082

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025