Protein: SIAS
N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase)

Gene: SIAS, NANS
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q9NR45

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006055 - CMP-N-acetylneuraminate biosynthetic process
GO:0016051 - carbohydrate biosynthetic process
GO:0046380 - N-acetylneuraminate biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

530425

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.547

High

224172

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.541

High

468835

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.536

High

170372

AURKA
Aurora kinase A

1

0

High-throughput

0.518

High

252376

TLR2
Toll-like receptor 2

1

0

High-throughput

0.518

High

353904

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.518

High

363904

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.518

High

549962

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.518

High

556365

CADH1
Cadherin-1

1

0

High-throughput

0.518

High

557488

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.518

High

659604

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.518

High

668724

APC
Adenomatous polyposis coli protein

1

0

High-throughput

0.518

High

764445

CTNA1
Catenin alpha-1

1

0

High-throughput

0.518

High

913410

MSH6
DNA mismatch repair protein Msh6

1

0

High-throughput

0.518

High

1090082

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

0

High-throughput

0.518

High

1154453

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

1338842

FLCN
Folliculin

1

0

High-throughput

0.518

High

1380189

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.518

High

209679

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.513

High

292933

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

317259

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.513

High

555526

SKIL
Ski-like protein

1

0

High-throughput

0.513

High

716395

BLVRB
Flavin reductase

1

0

High-throughput

0.513

High

963977

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.513

High

1106087

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.513

High

1447946

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

461962

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

967240

RRAS2
Ras-related protein R-Ras2

1

1

High-throughput

0.479

High

1157948

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

1162703

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

1

Small-scale

0.479

High

243033

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

347949

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

361927

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

446470

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

476198

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

568297

PLST
Plastin-3

1

0

High-throughput

0.458

High

607137

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

957848

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

1143982

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

1156870

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1185328

F161A
Protein FAM161A

1

0

High-throughput

0.458

High

1247008

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1255692

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1270430

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1327606

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.458

High

1391187

BICD1
Protein bicaudal D homolog 1

1

0

High-throughput

0.458

High

1431323

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1447939

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1447941

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

1447942

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1447943

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.458

High

142424

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.445

High

388016

FIBG
Fibrinogen gamma chain

1

0

High-throughput

0.426

High

598781

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1416722

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1447586

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1447938

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1447944

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

1447945

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.426

High

1144254

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

1447940

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.282

High

328267

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

1415876

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

260500

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

353575

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

373242

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

412663

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

589789

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

640298

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

696603

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769272

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1090558

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.249

Low

298091

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.232

Low

689862

CD27
CD27 antigen

1

0

High-throughput

0.232

Low

1104123

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1358206

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1420729

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

1435014

TM231
Transmembrane protein 231

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025