Protein: BTK
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) (Kinase EMB)

Gene: BTK
Organism: Mus musculus
Interactions: 44
UniProt ID: P35991

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001805 - positive regulation of type III hypersensitivity
GO:0001812 - positive regulation of type I hypersensitivity
GO:0001818 - negative regulation of cytokine production
GO:0002250 - adaptive immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

729739

BTK
Tyrosine-protein kinase BTK

2

20

Small-scale

0.778

High

643064

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

729764

BLNK
B-cell linker protein

2

20

Small-scale

0.754

High

729741

STAT3
Signal transducer and activator of transcription 3

1

15

Small-scale

0.647

High

729744

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

Small-scale

0.618

High

729760

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

16

Small-scale

0.618

High

729763

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

729748

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.596

High

729751

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.590

High

607535

MYD88
Myeloid differentiation primary response protein MyD88

1

15

Small-scale

0.536

High

729757

TCAM1
TIR domain-containing adapter molecule 1

1

8

Small-scale

0.536

High

648950

TNR5
Tumor necrosis factor receptor superfamily member 5

1

12

Small-scale

0.515

High

93619

E9Q604
Integrin alpha M

1

6

High-throughput

0.501

High

639483

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.479

High

729745

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

3

Small-scale

0.479

High

729752

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

729756

ARI3A
AT-rich interactive domain-containing protein 3A

1

1

Small-scale

0.479

High

729762

Q9ERL0
Btk-PH-domain binding protein

1

3

Small-scale

0.479

High

621178

IRF2
Interferon regulatory factor 2

1

0

Small-scale

0.458

High

729761

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

Small-scale

0.458

High

729765

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

393843

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.457

High

470227

H2AZ
Histone H2A.Z

1

1

High-throughput

0.457

High

666793

FRIL1
Ferritin light chain 1

1

2

High-throughput

0.457

High

729740

SMBP2
DNA-binding protein SMUBP-2

1

1

High-throughput

0.457

High

729742

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

2

High-throughput

0.457

High

729743

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.457

High

729746

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.457

High

729747

TBA1A
Tubulin alpha-1A chain

1

10

High-throughput

0.457

High

729749

CBX1
Chromobox protein homolog 1

1

5

High-throughput

0.457

High

729753

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.457

High

729754

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

High-throughput

0.457

High

729755

MRC1
Macrophage mannose receptor 1

1

4

High-throughput

0.457

High

729758

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

7

High-throughput

0.457

High

729766

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.457

High

140348

MA2B1
Lysosomal alpha-mannosidase

1

0

High-throughput

0.438

High

535698

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.438

High

543093

GLNA
Glutamine synthetase

1

0

High-throughput

0.438

High

729750

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.438

High

222666

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

High-throughput

0.417

High

729767

AP3B1
AP-3 complex subunit beta-1

1

6

High-throughput

0.417

High

657695

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.238

Low

729759

Q8BTX4
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024