Protein: KDM1B
Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B)

Gene: KDM1B
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q8NB78

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998553

H31
Histone H3.1

3

8

Small-scale

0.817

High

1333164

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

6

5

Small-scale

0.732

High

1260602

ASXL2
Putative Polycomb group protein ASXL2

5

4

High-throughput

0.718

High

1163066

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.691

High

1193347

GLYR1
Cytokine-like nuclear factor N-PAC

3

2

High-throughput

0.667

High

1161944

H31T
Histone H3.1t

1

8

Small-scale

0.647

High

1333160

KDM1B
Lysine-specific histone demethylase 2

1

8

Small-scale

0.647

High

980931

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.618

High

1017029

H33
Histone H3.3

1

8

High-throughput

0.618

High

1333170

NSD3
Histone-lysine N-methyltransferase NSD3

2

6

Small-scale

0.611

High

333691

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

3

1

High-throughput

0.609

High

1333172

SH22A
SH2 domain-containing protein 2A

3

3

High-throughput

0.609

High

260184

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

1141219

BRD3
Bromodomain-containing protein 3

2

7

High-throughput

0.584

High

396526

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

185857

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

Small-scale

0.561

High

183485

CASC3
Protein CASC3

1

6

High-throughput

0.536

High

445218

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

1014163

CBX1
Chromobox protein homolog 1

1

6

High-throughput

0.536

High

1144076

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1310234

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1333175

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.513

High

456955

CO8B
Complement component C8 beta chain

1

2

High-throughput

0.489

High

1104220

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

6

High-throughput

0.489

High

1233163

ABLM2
Actin-binding LIM protein 2

1

4

High-throughput

0.489

High

957134

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

0

Small-scale

0.480

High

143121

NFIB
Nuclear factor 1 B-type

1

6

High-throughput

0.479

High

474128

NFIC
Nuclear factor 1 C-type

1

10

High-throughput

0.479

High

674249

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

675589

TYY1
Transcriptional repressor protein YY1

1

7

High-throughput

0.479

High

739007

ELF1
ETS-related transcription factor Elf-1

1

1

High-throughput

0.479

High

904938

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

965092

WDR5
WD repeat-containing protein 5

1

3

Small-scale

0.479

High

979997

H4
Histone H4

1

1

High-throughput

0.479

High

1029714

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.479

High

1045530

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1087870

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.479

High

1113717

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1129652

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.479

High

1130108

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

Small-scale

0.479

High

1257075

PAXI1
PAX-interacting protein 1

1

4

Small-scale

0.479

High

1333161

KMT2C
Histone-lysine N-methyltransferase 2C

1

10

Small-scale

0.479

High

1333165

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1333167

MBD6
Methyl-CpG-binding domain protein 6

1

6

High-throughput

0.479

High

1333168

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

9

Small-scale

0.479

High

1333174

MBD5
Methyl-CpG-binding domain protein 5

1

1

High-throughput

0.479

High

251624

CCNT1
Cyclin-T1

1

0

Small-scale

0.458

High

1218601

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1333173

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

96010

E7EWD6
ASXL transcriptional regulator 2

1

5

High-throughput

0.445

High

107393

F8W6N3
Ubiquitin carboxyl-terminal hydrolase

1

5

High-throughput

0.445

High

1333171

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

1333163

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.407

High

1333169

SPT17
Spermatogenesis-associated protein 17

3

0

High-throughput

0.342

High

1279008

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

1333162

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

634135

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

1278613

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1333166

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025