Protein: NR0B2
Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)

Gene: NR0B2
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q15466

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137538

NR5A2
Nuclear receptor subfamily 5 group A member 2

9

19

Small-scale

0.970

High

833946

HNF4A
Hepatocyte nuclear factor 4-alpha

8

20

Small-scale

0.967

High

976897

ERR3
Estrogen-related receptor gamma

5

19

Small-scale

0.925

High

625818

RXRA
Retinoic acid receptor RXR-alpha

3

19

Small-scale

0.833

High

1095498

NR1H3
Oxysterols receptor LXR-alpha

2

18

Small-scale

0.815

High

396174

ESR1
Estrogen receptor

2

20

Small-scale

0.793

High

520074

ANDR
Androgen receptor

2

20

Small-scale

0.793

High

520584

RARA
Retinoic acid receptor alpha

2

19

Small-scale

0.793

High

789500

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.792

High

933942

NR1H2
Oxysterols receptor LXR-beta

2

18

Small-scale

0.768

High

404073

GCR
Glucocorticoid receptor

2

20

Small-scale

0.715

High

1109752

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.707

High

282940

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.680

High

903164

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

3

20

Small-scale

0.678

High

1149276

SIN3A
Paired amphipathic helix protein Sin3a

3

1

Small-scale

0.664

High

1149284

CILK1
Serine/threonine-protein kinase ICK

3

5

High-throughput

0.662

High

533283

THA
Thyroid hormone receptor alpha

1

19

Small-scale

0.647

High

873159

RXRG
Retinoic acid receptor RXR-gamma

1

19

Small-scale

0.647

High

188285

HDAC3
Histone deacetylase 3

2

20

Small-scale

0.643

High

413891

P53
Cellular tumor antigen p53

2

3

Small-scale

0.641

High

1149287

EID1
EP300-interacting inhibitor of differentiation 1

3

0

Small-scale

0.633

High

389385

FINC
Fibronectin

1

1

High-throughput

0.621

High

543508

VDR
Vitamin D3 receptor

1

20

High-throughput

0.621

High

543575

ERR1
Steroid hormone receptor ERR1

1

20

High-throughput

0.621

High

565522

RARG
Retinoic acid receptor gamma

1

19

High-throughput

0.621

High

1041752

PPARD
Peroxisome proliferator-activated receptor delta

1

20

High-throughput

0.621

High

1127872

HNF4G
Hepatocyte nuclear factor 4-gamma

1

20

High-throughput

0.621

High

1149288

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.621

High

1028212

MDM2
E3 ubiquitin-protein ligase Mdm2

2

2

Small-scale

0.612

High

1149271

CIDEC
Lipid transferase CIDEC

2

1

High-throughput

0.606

High

1149272

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

14

Small-scale

0.589

High

1149285

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.580

High

1110777

NDF1
Neurogenic differentiation factor 1

1

7

Small-scale

0.573

High

141501

DDX3X
ATP-dependent RNA helicase DDX3X

1

11

Small-scale

0.561

High

1098551

GPS2
G protein pathway suppressor 2

1

2

Small-scale

0.561

High

1149281

HNF6
Hepatocyte nuclear factor 6

1

13

Small-scale

0.561

High

608973

XBP1
X-box-binding protein 1

1

1

High-throughput

0.541

High

849070

ZAP70
Tyrosine-protein kinase ZAP-70

1

3

High-throughput

0.541

High

938449

PAX9
Paired box protein Pax-9

1

14

High-throughput

0.541

High

1106546

SMAD4
Mothers against decapentaplegic homolog 4

1

8

High-throughput

0.541

High

1036519

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.527

High

294628

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

High-throughput

0.518

High

896760

DYN2
Dynamin-2

1

2

High-throughput

0.515

High

1149267

ARH
Low density lipoprotein receptor adapter protein 1

1

0

High-throughput

0.513

High

1149274

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

667310

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

Small-scale

0.501

High

1086598

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

Small-scale

0.501

High

1149270

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

7

Small-scale

0.501

High

1149282

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.501

High

927002

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1149280

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

1

1

High-throughput

0.489

High

180521

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.481

High

485163

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

15

High-throughput

0.481

High

1013193

RET5
Retinol-binding protein 5

1

4

High-throughput

0.481

High

1111005

SNW1
SNW domain-containing protein 1

1

8

High-throughput

0.481

High

1149283

PEF1
Peflin

1

1

High-throughput

0.481

High

297617

PIAS1
E3 SUMO-protein ligase PIAS1

1

8

Small-scale

0.479

High

648361

USF1
Upstream stimulatory factor 1

1

9

Small-scale

0.479

High

1034873

SP2
Transcription factor Sp2

1

20

Small-scale

0.479

High

1119470

RUNX2
Runt-related transcription factor 2

1

3

Small-scale

0.479

High

1149268

SIR6
NAD-dependent protein deacylase sirtuin-6

1

14

Small-scale

0.479

High

1149269

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

Small-scale

0.479

High

1149275

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

9

Small-scale

0.479

High

1149277

KLF6
Krueppel-like factor 6

1

20

Small-scale

0.479

High

1149279

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

Small-scale

0.479

High

1149286

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.479

High

1149273

RNF31
E3 ubiquitin-protein ligase RNF31

1

9

Small-scale

0.439

High

1149278

CHRD
Chordin

1

2

High-throughput

0.439

High

689945

IL3RA
Interleukin-3 receptor subunit alpha

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025