Protein: PHS2
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)

Gene: PHS2, PCBD2
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q9H0N5

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0006729 - tetrahydrobiopterin biosynthetic process
GO:0008124 - 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0045893 - positive regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961638

PHS
Pterin-4-alpha-carbinolamine dehydratase

2

5

High-throughput

0.817

High

635217

HNF1A
Hepatocyte nuclear factor 1-alpha

4

6

Small-scale

0.694

High

848939

MAGAB
Melanoma-associated antigen 11

3

1

High-throughput

0.616

High

775907

HNF1B
Hepatocyte nuclear factor 1-beta

2

6

High-throughput

0.611

High

1242698

KLC3
Kinesin light chain 3

2

1

High-throughput

0.606

High

848437

MAGA6
Melanoma-associated antigen 6

2

1

High-throughput

0.553

High

1306983

CERS3
Ceramide synthase 3

2

1

High-throughput

0.553

High

1430249

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

Small-scale

0.552

High

423130

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.550

High

539410

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

827921

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.518

High

1393377

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.518

High

1430244

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.518

High

238789

SSX5
Protein SSX5

1

1

High-throughput

0.494

High

320356

PHF14
PHD finger protein 14

1

1

High-throughput

0.494

High

714415

PML
Protein PML

1

1

High-throughput

0.494

High

1315049

ZZZ3
ZZ-type zinc finger-containing protein 3

1

1

High-throughput

0.494

High

1371355

TF3B
Transcription factor IIIB 90 kDa subunit

1

1

High-throughput

0.494

High

1408098

SSX3
Protein SSX3

1

1

High-throughput

0.494

High

1430243

HES4
Transcription factor HES-4

1

1

High-throughput

0.494

High

1430248

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

242876

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

298075

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.316

High

1349654

PPL13
Placental protein 13-like

2

0

High-throughput

0.316

High

1399228

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1430246

SPG21
Maspardin

2

0

High-throughput

0.316

High

1430250

MOFA1
MORF4 family-associated protein 1

2

0

High-throughput

0.316

High

219516

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.282

High

608989

XBP1
X-box-binding protein 1

1

0

High-throughput

0.282

High

708916

T2EA
General transcription factor IIE subunit 1

1

0

High-throughput

0.282

High

1055274

MTG8
Protein CBFA2T1

1

0

High-throughput

0.282

High

1094732

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.282

High

1108398

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.282

High

1111258

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.282

High

1119076

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.282

High

1158750

TAL2
T-cell acute lymphocytic leukemia protein 2

1

0

High-throughput

0.282

High

1306956

I2BP1
Interferon regulatory factor 2-binding protein 1

1

0

High-throughput

0.282

High

1307244

TF2LY
Homeobox protein TGIF2LY

1

0

High-throughput

0.282

High

1383461

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.282

High

1404383

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.282

High

1412120

CENPK
Centromere protein K

1

0

High-throughput

0.282

High

1430242

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.282

High

1430245

AATF
Protein AATF

1

0

High-throughput

0.282

High

1430247

CSEN
Calsenilin

1

0

High-throughput

0.282

High

897076

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.269

Low

1389479

NTCP4
Sodium/bile acid cotransporter 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025