Protein: CENPU
Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)

Gene: CENPU
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q71F23

Gene Ontology (top 5):
GO:0000939 - inner kinetochore
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007059 - chromosome segregation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1258998

CENPQ
Centromere protein Q

7

0

Small-scale

0.919

High

1259010

CENPN
Centromere protein N

3

0

Small-scale

0.803

High

920061

PLK1
Serine/threonine-protein kinase PLK1

7

2

Small-scale

0.752

High

1259025

CENPH
Centromere protein H

7

0

Small-scale

0.715

High

1234720

CENPP
Centromere protein P

7

0

Small-scale

0.714

High

1259018

CENPO
Centromere protein O

6

0

Small-scale

0.702

High

1259005

CENPI
Centromere protein I

5

0

Small-scale

0.688

High

1102996

CENPR
Centromere protein R

5

0

High-throughput

0.686

High

789149

NUP62
Nuclear pore glycoprotein p62

3

1

High-throughput

0.674

High

1259012

ZN512
Zinc finger protein 512

2

1

High-throughput

0.628

High

1259032

CENPM
Centromere protein M

3

0

Small-scale

0.628

High

883589

CENPA
Histone H3-like centromeric protein A

3

0

Small-scale

0.613

High

208291

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

841390

RBM34
RNA-binding protein 34

2

0

High-throughput

0.602

High

859880

RL28
Large ribosomal subunit protein eL28

2

0

High-throughput

0.602

High

977027

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

0

High-throughput

0.602

High

1037534

RL18A
Large ribosomal subunit protein eL20

2

0

High-throughput

0.602

High

1041831

CENPC
Centromere protein C

2

0

High-throughput

0.602

High

1259004

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

1259017

ZNF2
Zinc finger protein 2

2

0

High-throughput

0.602

High

1259020

RBM4
RNA-binding protein 4

2

0

High-throughput

0.602

High

1259036

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.601

High

1259007

CENPT
Centromere protein T

2

0

Small-scale

0.585

High

1259016

CENPK
Centromere protein K

2

0

Small-scale

0.585

High

1259000

CENPL
Centromere protein L

2

0

Small-scale

0.559

High

287030

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.536

High

1008778

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.536

High

1089723

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.536

High

1099133

SRSF5
Serine/arginine-rich splicing factor 5

1

2

High-throughput

0.536

High

1099407

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1259037

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.536

High

70867

CENPX
Centromere protein X

1

0

High-throughput

0.513

High

163985

NDC80
Kinetochore protein NDC80 homolog

1

0

High-throughput

0.513

High

191685

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

253649

IMA7
Importin subunit alpha-7

1

0

High-throughput

0.513

High

428826

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.513

High

596184

H12
Histone H1.2

1

0

High-throughput

0.513

High

686226

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

693806

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

785245

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

788693

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

883913

CENPF
Centromere protein F

1

0

High-throughput

0.513

High

948545

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

960774

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

975769

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

985219

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

985728

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1063132

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.513

High

1117580

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

1137084

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.513

High

1210720

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.513

High

1228588

SPT2
Protein SPT2 homolog

1

0

High-throughput

0.513

High

1258999

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1259001

MIER1
Mesoderm induction early response protein 1

1

0

High-throughput

0.513

High

1259008

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1259014

ZNF48
Zinc finger protein 48

1

0

High-throughput

0.513

High

1259015

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1259030

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

0

High-throughput

0.513

High

1259031

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1259041

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.513

High

1259043

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

1259044

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.513

High

946153

MLF1
Myeloid leukemia factor 1

1

0

Small-scale

0.504

High

474772

VIME
Vimentin

1

0

High-throughput

0.493

High

208131

PLXB1
Plexin-B1

1

1

High-throughput

0.489

High

1247744

NHS
Actin remodeling regulator NHS

1

1

High-throughput

0.489

High

1259023

N62CL
Nucleoporin-62 C-terminal-like protein

1

1

High-throughput

0.489

High

558222

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

1047034

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.486

High

1259019

TBB2B
Tubulin beta-2B chain

1

0

High-throughput

0.486

High

1259024

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

0

High-throughput

0.486

High

1259042

GIT1
ARF GTPase-activating protein GIT1

1

0

High-throughput

0.486

High

185799

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1067453

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1129634

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

1257062

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

175388

PLXB2
Plexin-B2

1

1

High-throughput

0.464

High

282738

E2F6
Transcription factor E2F6

1

0

Small-scale

0.460

High

1259028

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

406309

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

799231

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

1259002

CENPS
Centromere protein S

1

0

Small-scale

0.458

High

1259011

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1259021

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1259035

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1259038

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1259040

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

529998

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

601744

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

967474

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.426

High

1063964

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.426

High

1259022

REXO4
RNA exonuclease 4

1

0

High-throughput

0.426

High

1259027

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1259026

PLK3
Serine/threonine-protein kinase PLK3

1

2

Small-scale

0.408

High

1259034

PLK2
Serine/threonine-protein kinase PLK2

1

2

Small-scale

0.408

High

546981

FGF3
Fibroblast growth factor 3

2

0

High-throughput

0.328

High

1168521

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.328

High

208696

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.279

Low

694364

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

1127412

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1218105

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1241176

MET2B
tRNA N(3)-cytidine methyltransferase METTL2B

1

0

High-throughput

0.279

Low

1259003

MITD1
MIT domain-containing protein 1

1

0

High-throughput

0.279

Low

1259006

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1259009

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1259013

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

130143

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.265

Low

275682

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.265

Low

535860

LAMC1
Laminin subunit gamma-1

1

0

High-throughput

0.265

Low

1259029

ROBO2
Roundabout homolog 2

1

0

High-throughput

0.265

Low

1259033

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low

1259039

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025