Protein: TM222
Transmembrane protein 222

Gene: TM222, TMEM222
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9H0R3

Gene Ontology (top 5):
GO:0016020 - membrane
GO:0030425 - dendrite

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476030

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

0

High-throughput

0.638

High

1384348

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

138577

CLD5
Claudin-5

2

0

High-throughput

0.580

High

161366

PTGES
Prostaglandin E synthase

2

0

High-throughput

0.580

High

642287

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.580

High

850852

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

0

High-throughput

0.580

High

1242813

RNK
Ribonuclease kappa

2

0

High-throughput

0.580

High

1349112

F174A
Membrane protein FAM174A

2

0

High-throughput

0.580

High

1359313

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

1383058

LRC59
Leucine-rich repeat-containing protein 59

2

0

High-throughput

0.580

High

1430296

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

1430298

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

1090031

NTCP2
Ileal sodium/bile acid cotransporter

2

2

High-throughput

0.553

High

1109042

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

1134163

NTCP
Hepatic sodium/bile acid cotransporter

2

2

High-throughput

0.553

High

1428506

ELOV4
Very long chain fatty acid elongase 4

2

4

High-throughput

0.553

High

132657

UPK1A
Uroplakin-1a

1

2

High-throughput

0.536

High

350413

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

Small-scale

0.486

High

230428

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.481

High

375928

RASK
GTPase KRas

1

1

High-throughput

0.479

High

117019

J3KQ12
Seipin

1

1

High-throughput

0.470

High

975231

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1186041

SOAT
Sodium-dependent organic anion transporter

1

2

High-throughput

0.439

High

1391502

BSCL2
Seipin

1

1

High-throughput

0.439

High

256146

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

1430293

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

142111

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

188995

TMPS2
Transmembrane protease serine 2

2

0

High-throughput

0.316

High

549883

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

728888

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

761166

EVI2B
Protein EVI2B

2

0

High-throughput

0.316

High

946341

CLRN1
Clarin-1

2

0

High-throughput

0.316

High

1102452

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1142938

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

1159632

STX1A
Syntaxin-1A

2

0

High-throughput

0.316

High

1198907

NACHO
Novel acetylcholine receptor chaperone

2

0

High-throughput

0.316

High

1207614

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1228651

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

0

High-throughput

0.316

High

1279364

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.316

High

1291488

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

1398511

ZDH15
Palmitoyltransferase ZDHHC15

2

0

High-throughput

0.316

High

1414228

CRUM3
Protein crumbs homolog 3

2

0

High-throughput

0.316

High

1430295

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1430299

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.316

High

326269

PRS23
Serine protease 23

1

0

High-throughput

0.282

High

1029940

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.282

High

1055141

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.279

Low

1430294

RTN4
Reticulon-4

1

0

High-throughput

0.279

Low

386215

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

956482

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.249

Low

1392460

TECT2
Tectonic-2

1

0

High-throughput

0.249

Low

1430297

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025