Protein: 3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)

Gene: 3HIDH, HIBADH
Organism: Homo sapiens
Interactions: 75
UniProt ID: P31937

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006574 - L-valine catabolic process
GO:0008442 - 3-hydroxyisobutyrate dehydrogenase activity
GO:0050661 - NADP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688374

PPLA
Phospholamban

2

0

High-throughput

0.580

High

728896

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

2

0

High-throughput

0.580

High

728850

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

6

Small-scale

0.575

High

728883

ZN692
Zinc finger protein 692

2

1

High-throughput

0.574

High

328634

VAMP5
Vesicle-associated membrane protein 5

2

1

High-throughput

0.553

High

390471

TFR1
Transferrin receptor protein 1

2

1

High-throughput

0.553

High

728854

VAMP2
Vesicle-associated membrane protein 2

2

1

High-throughput

0.553

High

728870

CLC2A
C-type lectin domain family 2 member A

2

1

High-throughput

0.553

High

728873

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

1

High-throughput

0.553

High

728877

AQP3
Aquaporin-3

2

3

High-throughput

0.553

High

728881

AMELY
Amelogenin, Y isoform

2

1

High-throughput

0.553

High

261936

RNH1
Ribonuclease H1

1

0

High-throughput

0.513

High

728874

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

728882

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.513

High

728851

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.504

High

317137

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

High-throughput

0.489

High

475220

A2AP
Alpha-2-antiplasmin

1

1

High-throughput

0.489

High

728864

ECM1
Extracellular matrix protein 1

1

1

High-throughput

0.489

High

728880

CREL1
Protein disulfide isomerase CRELD1

1

2

High-throughput

0.489

High

728897

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

1

2

High-throughput

0.489

High

728856

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

4

High-throughput

0.479

High

728857

Q08AM2
ADAM33 protein

1

1

High-throughput

0.470

High

728865

Q59EV6
Carboxypeptidase

1

1

High-throughput

0.470

High

529188

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

528663

PPGB
Lysosomal protective protein

1

1

High-throughput

0.439

High

728878

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

Small-scale

0.439

High

728886

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.439

High

105429

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

728852

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.437

High

728863

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

728872

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

728885

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

728891

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

3

Small-scale

0.437

High

653154

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

728858

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

728862

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

728889

S2532
Solute carrier family 25 member 32

1

0

High-throughput

0.426

High

728894

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

728855

1433Z
14-3-3 protein zeta/delta

1

2

Small-scale

0.417

High

142285

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.407

High

330058

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

155440

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.316

High

160243

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.316

High

257606

PRAF2
PRA1 family protein 2

2

0

High-throughput

0.316

High

280134

SC22B
Vesicle-trafficking protein SEC22b

2

0

High-throughput

0.316

High

327176

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.316

High

339209

SFT2B
Vesicle transport protein SFT2B

2

0

High-throughput

0.316

High

341397

CDS2
Phosphatidate cytidylyltransferase 2

2

0

High-throughput

0.316

High

455903

ASGR1
Asialoglycoprotein receptor 1

2

0

High-throughput

0.316

High

482232

PAEP
Glycodelin

2

0

High-throughput

0.316

High

636202

MAL
Myelin and lymphocyte protein

2

0

High-throughput

0.316

High

642201

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.316

High

728853

EFNA5
Ephrin-A5

2

0

High-throughput

0.316

High

728860

PTC1
Protein patched homolog 1

2

0

High-throughput

0.316

High

728861

SCRB2
Lysosome membrane protein 2

2

0

High-throughput

0.316

High

728866

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

728868

CNIH2
Protein cornichon homolog 2

2

0

High-throughput

0.316

High

728869

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.316

High

728871

SNORC
Protein SNORC

2

0

High-throughput

0.316

High

728876

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

728879

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

0

High-throughput

0.316

High

728887

TM6S2
Transmembrane 6 superfamily member 2

2

0

High-throughput

0.316

High

728888

TM222
Transmembrane protein 222

2

0

High-throughput

0.316

High

728890

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

728893

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

728895

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.316

High

728899

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.316

High

143961

EST2
Cocaine esterase

1

0

High-throughput

0.279

Low

728867

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

728875

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.279

Low

728892

SNTG1
Gamma-1-syntrophin

1

0

High-throughput

0.279

Low

728859

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

728884

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.232

Low

728898

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025