Protein: TRM6
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)

Gene: TRM6, TRMT6
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9UJA5

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006397 - mRNA processing
GO:0030488 - tRNA methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1391115

TRM61
tRNA

4

2

Small-scale

0.895

High

960604

PSME3
Proteasome activator complex subunit 3

3

0

High-throughput

0.638

High

1041804

PPARD
Peroxisome proliferator-activated receptor delta

3

0

High-throughput

0.638

High

1411855

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

0

High-throughput

0.638

High

1199744

KLH22
Kelch-like protein 22

3

0

High-throughput

0.634

High

884263

SRP09
Signal recognition particle 9 kDa protein

2

0

High-throughput

0.602

High

1460569

TRM6
tRNA

1

0

High-throughput

0.586

High

1106115

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

0

High-throughput

0.585

High

986800

PPIA
Peptidyl-prolyl cis-trans isomerase A

2

0

High-throughput

0.575

High

1459233

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

1040503

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

0

High-throughput

0.518

High

1370928

FOXJ1
Forkhead box protein J1

1

0

High-throughput

0.518

High

63276

VP37C
Vacuolar protein sorting-associated protein 37C

1

0

High-throughput

0.513

High

431273

LA
Lupus La protein

1

0

High-throughput

0.513

High

440774

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.513

High

1028441

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.513

High

1114600

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1144210

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1258272

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

0

High-throughput

0.513

High

1291266

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1388764

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.513

High

1395845

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1446485

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.513

High

966992

1433G
14-3-3 protein gamma

1

0

High-throughput

0.493

High

1139867

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.493

High

1347407

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

1371323

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

186106

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

401671

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

998925

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017282

H33
Histone H3.3

1

1

High-throughput

0.479

High

1402337

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

243235

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

346465

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

696807

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

971259

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

981169

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1033809

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1087612

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1161742

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1415902

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1437230

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1446425

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1447410

ANLN
Anillin

1

0

High-throughput

0.458

High

1452464

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1460277

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1460570

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1460572

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

960291

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.445

High

1087697

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

1

High-throughput

0.437

High

1220875

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

191856

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

208419

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

288812

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.426

High

409531

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

430482

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

601899

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

785518

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.426

High

810450

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

898877

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.426

High

1037433

H11
Histone H1.1

1

0

High-throughput

0.426

High

1239973

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1315263

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.426

High

1346975

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.426

High

1402450

CCNL2
Cyclin-L2

1

0

High-throughput

0.426

High

1437545

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1237973

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

0

High-throughput

0.328

High

219244

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.279

Low

479230

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.279

Low

518633

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.279

Low

838514

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.279

Low

1119914

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.279

Low

1335225

NETO2
Neuropilin and tolloid-like protein 2

1

0

High-throughput

0.279

Low

1364069

NICA
Nicastrin

1

0

High-throughput

0.279

Low

1369511

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1460571

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1460573

RPGF2
Rap guanine nucleotide exchange factor 2

1

0

High-throughput

0.279

Low

106818

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

294499

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

412773

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

867497

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low

1256010

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1327254

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

62609

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

652686

GNLY
Granulysin

1

0

High-throughput

0.232

Low

1452970

USE1
Vesicle transport protein USE1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025