Protein: CHK1
Serine/threonine-protein kinase CHK1 (EC 2.7.11.1) (Checkpoint kinase 1)

Gene: CHK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P38147

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

744975

ACT
Actin

2

4

High-throughput

0.798

High

409896

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.691

High

744978

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.691

High

412973

KAPB
cAMP-dependent protein kinase type 2

1

7

High-throughput

0.665

High

744958

SECU
Securin

3

0

Small-scale

0.652

High

633158

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.646

High

539922

RAD9
DNA repair protein RAD9

4

0

Small-scale

0.644

High

543608

HSC82
ATP-dependent molecular chaperone HSC82

1

18

Small-scale

0.621

High

744952

CHK1
Serine/threonine-protein kinase CHK1

1

18

Small-scale

0.621

High

744973

YNX4
Uncharacterized globin-like protein YNL234W

2

0

Small-scale

0.565

High

355461

H2B1
Histone H2B.1

1

9

High-throughput

0.536

High

355874

H2B2
Histone H2B.2

1

9

High-throughput

0.536

High

416222

SIR2
NAD-dependent histone deacetylase SIR2

1

3

High-throughput

0.536

High

501358

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.536

High

744976

H3
Histone H3

1

4

High-throughput

0.536

High

587307

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.520

High

434526

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

744953

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.513

High

744969

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.513

High

744970

PNC1
Nicotinamidase

1

0

High-throughput

0.513

High

744971

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.513

High

744982

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.513

High

648312

GYS2
Glycogen [starch] synthase isoform 2

1

1

High-throughput

0.508

High

710438

SAS3
Histone acetyltransferase SAS3

1

2

Small-scale

0.508

High

744964

LSM1
Sm-like protein LSm1

1

1

High-throughput

0.508

High

343290

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.501

High

608691

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.501

High

699779

KPR1
Ribose-phosphate pyrophosphokinase 1

1

5

High-throughput

0.501

High

744963

ELP2
Elongator complex protein 2

1

2

High-throughput

0.501

High

744968

ASNS1
Asparagine synthetase [glutamine-hydrolyzing] 1

1

3

High-throughput

0.501

High

744983

EMI2
Putative glucokinase-2

1

1

High-throughput

0.501

High

424475

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.500

High

440021

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.500

High

562365

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

744962

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.500

High

540079

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

3

High-throughput

0.489

High

744965

NET1
Nucleolar protein NET1

1

1

High-throughput

0.489

High

744979

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.489

High

744980

YMZ2
WD repeat-containing protein YMR102C

1

3

High-throughput

0.489

High

744984

GFD1
mRNA transport factor GFD1

1

0

High-throughput

0.486

High

587911

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.480

High

704297

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.480

High

744967

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.480

High

744972

TR112
Multifunctional methyltransferase subunit TRM112

1

0

High-throughput

0.480

High

498501

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

604545

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

744961

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

1

High-throughput

0.479

High

744986

H2AZ
Histone H2A.Z

1

2

High-throughput

0.479

High

662014

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

744955

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

744981

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

342912

ENO2
Enolase 2

1

2

High-throughput

0.457

High

381699

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

744954

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

1

High-throughput

0.457

High

744957

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

3

High-throughput

0.457

High

378333

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

490988

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

493765

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

511036

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

744956

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

744977

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

1

1

High-throughput

0.445

High

420491

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.438

High

744959

SDS3
Transcriptional regulatory protein SDS3

1

0

High-throughput

0.438

High

744985

SWR1
Helicase SWR1

1

0

High-throughput

0.426

High

744974

YL152
Uncharacterized transporter YLR152C

1

0

High-throughput

0.279

Low

744960

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

744966

SNX4
Sorting nexin-4

1

0

High-throughput

0.238

Low

61577

YP010
UPF0495 protein YPR010C-A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024