Protein: SAM50
Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3)

Gene: SAM50, SAMM50
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q9Y512

Gene Ontology (top 5):
GO:0001401 - SAM complex
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0007007 - inner mitochondrial membrane organization
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

281696

MTX2
Metaxin-2

6

4

Small-scale

0.952

High

1108474

MTX1
Metaxin-1

2

5

Small-scale

0.806

High

1216425

FAXC
Failed axon connections homolog

2

4

High-throughput

0.776

High

354425

TOM40
Mitochondrial import receptor subunit TOM40 homolog

2

2

Small-scale

0.768

High

1451877

MIC19
MICOS complex subunit MIC19

6

2

Small-scale

0.740

High

641079

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

Small-scale

0.724

High

1164637

MIC60
MICOS complex subunit MIC60

4

1

Small-scale

0.689

High

1411615

MIC25
MICOS complex subunit MIC25

3

2

High-throughput

0.653

High

135745

DNM1L
Dynamin-1-like protein

2

1

Small-scale

0.624

High

1108321

SQSTM
Sequestosome-1

2

2

Small-scale

0.624

High

1250129

MIC27
MICOS complex subunit MIC27

2

1

High-throughput

0.611

High

1450517

DJC11
DnaJ homolog subfamily C member 11

2

3

High-throughput

0.611

High

1462598

TRAK1
Trafficking kinesin-binding protein 1

2

1

High-throughput

0.601

High

348814

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

2

High-throughput

0.588

High

326636

MFN2
Mitofusin-2

2

1

Small-scale

0.584

High

1491480

MTCH2
Mitochondrial carrier homolog 2

2

3

High-throughput

0.571

High

243401

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

560138

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

1417115

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

0

Small-scale

0.559

High

1429155

MFF
Mitochondrial fission factor

2

0

Small-scale

0.559

High

1449133

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

Small-scale

0.559

High

1420332

CD244
Natural killer cell receptor 2B4

2

1

High-throughput

0.549

High

407015

A1BG
Alpha-1B-glycoprotein

1

0

Small-scale

0.537

High

244880

TRAK2
Trafficking kinesin-binding protein 2

1

1

High-throughput

0.536

High

351994

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.536

High

397319

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

538724

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.536

High

956032

RAB8A
Ras-related protein Rab-8A

1

1

High-throughput

0.536

High

1349597

S22A8
Organic anion transporter 3

1

3

High-throughput

0.536

High

1452281

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

4

High-throughput

0.536

High

1454080

SLAF8
SLAM family member 8

1

1

High-throughput

0.536

High

731739

STIP1
Stress-induced-phosphoprotein 1

2

4

High-throughput

0.533

High

49756

TMM72
Transmembrane protein 72

1

0

High-throughput

0.513

High

1034853

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1120523

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1168766

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1325962

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1336537

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.513

High

1350157

SPP
Signal peptide peptidase

1

0

High-throughput

0.513

High

1350928

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1363262

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1391676

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

1446601

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

1433258

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

Small-scale

0.512

High

508898

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

1428441

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

Small-scale

0.501

High

166076

FFAR1
Free fatty acid receptor 1

1

1

High-throughput

0.489

High

855274

GPR3
G-protein coupled receptor 3

1

1

High-throughput

0.489

High

1382404

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.489

High

245562

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

259190

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

276197

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.479

High

340271

PCNT
Pericentrin

1

1

High-throughput

0.479

High

610959

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.479

High

786316

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

821637

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.479

High

857002

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.479

High

876237

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.479

High

882234

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.479

High

899645

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.479

High

901712

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.479

High

1007356

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.479

High

1036024

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1038733

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.479

High

1090604

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

Small-scale

0.479

High

1125751

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

4

High-throughput

0.479

High

1216505

MIC10
MICOS complex subunit MIC10

1

2

Small-scale

0.479

High

1278160

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.479

High

1309749

MFN1
Mitofusin-1

1

1

Small-scale

0.479

High

1312313

MIRO2
Mitochondrial Rho GTPase 2

1

2

High-throughput

0.479

High

1367686

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1397204

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.479

High

1397690

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1403487

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1403757

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

1405927

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

1407649

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.479

High

1409627

NIPS1
Protein NipSnap homolog 1

1

1

Small-scale

0.479

High

1414693

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

1429527

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.479

High

1431231

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

1491458

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

687323

HMGB2
High mobility group protein B2

1

1

High-throughput

0.464

High

106923

APRIO
Alternative prion protein

1

0

High-throughput

0.458

High

133825

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

137855

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

162386

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.458

High

216856

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

292260

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

296325

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

320185

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

364087

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

447625

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

837919

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

983621

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

High-throughput

0.458

High

1013478

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1101206

CLN3
Battenin

1

0

Small-scale

0.458

High

1107680

MTM1
Myotubularin

1

0

High-throughput

0.458

High

1141106

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1149657

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1158624

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1220544

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.458

High

1270691

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1366643

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1382987

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

Small-scale

0.458

High

1388613

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1394070

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1412372

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

1420442

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1428843

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

1432339

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1433147

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1433705

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

1436980

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1437993

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1438346

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1447154

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

1447796

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1451369

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1451768

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1461363

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1491207

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

328207

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

Small-scale

0.457

High

1417427

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

4

Small-scale

0.457

High

1131652

MFS10
Major facilitator superfamily domain-containing protein 10

1

5

High-throughput

0.445

High

1348096

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

3

High-throughput

0.445

High

1417177

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

64587

MP3B2
Microtubule-associated protein 1 light chain 3 beta 2

1

4

Small-scale

0.437

High

155817

TXND9
Thioredoxin domain-containing protein 9

1

3

High-throughput

0.437

High

215363

TXNL1
Thioredoxin-like protein 1

1

1

High-throughput

0.437

High

331446

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

883379

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.437

High

971357

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1103681

PHLP
Phosducin-like protein

1

3

High-throughput

0.437

High

1288615

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1414659

TCAB1
Telomerase Cajal body protein 1

1

2

High-throughput

0.437

High

1417860

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.437

High

1431934

PDCL3
Phosducin-like protein 3

1

3

High-throughput

0.437

High

1435204

RPAP3
RNA polymerase II-associated protein 3

1

3

High-throughput

0.437

High

1445761

WDR6
tRNA

1

1

High-throughput

0.437

High

1173

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

1280831

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.426

High

1346842

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

1007389

S35A2
UDP-galactose translocator

1

1

High-throughput

0.407

High

1007467

S35B1
Solute carrier family 35 member B1

1

3

High-throughput

0.407

High

1227778

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1348825

S35G2
Solute carrier family 35 member G2

1

3

High-throughput

0.407

High

1381046

S35B4
Nucleotide sugar transporter SLC35B4

1

3

High-throughput

0.407

High

1399244

PCFT
Proton-coupled folate transporter

1

1

High-throughput

0.407

High

1431176

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

4

High-throughput

0.407

High

1490680

S35A3
UDP-N-acetylglucosamine transporter

1

1

High-throughput

0.407

High

1447501

ANLN
Anillin

2

0

High-throughput

0.305

High

894268

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.282

High

986917

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

0

High-throughput

0.279

Low

1086732

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

1116172

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.279

Low

1287188

T150A
Transmembrane protein 150A

1

0

High-throughput

0.279

Low

1291533

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

1291926

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

0

High-throughput

0.279

Low

1347266

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.279

Low

1358937

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.279

Low

1452202

CLC5A
C-type lectin domain family 5 member A

1

0

High-throughput

0.279

Low

1491479

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

188399

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.249

Low

261899

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.249

Low

353651

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

373611

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

451302

NFL
Neurofilament light polypeptide

1

0

High-throughput

0.249

Low

590132

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696972

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769614

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

963395

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.249

Low

1086946

CDC20
Cell division cycle protein 20 homolog

1

0

High-throughput

0.249

Low

1107375

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1137611

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

1178484

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1197768

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1203104

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1249365

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256259

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1295605

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.249

Low

1308115

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.249

Low

1308619

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.249

Low

1353442

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.249

Low

1365543

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

1397857

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

1398632

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

1404707

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.249

Low

1429419

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1434337

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1435501

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1436586

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

1438910

MOV10
Helicase MOV-10

1

0

High-throughput

0.249

Low

1448930

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.249

Low

1452404

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1453343

DTL
Denticleless protein homolog

1

0

High-throughput

0.249

Low

1459450

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

766055

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low

1180340

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low

1311194

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.232

Low

1361333

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.232

Low

1389640

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1490944

KLDC2
Kelch domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025