Protein: SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)

Gene: SAMH1, SAMHD1
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9Y3Z3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003676 - nucleic acid binding
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding
GO:0004540 - RNA nuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1377763

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

4

0

Small-scale

0.862

High

590240

CCNA2
Cyclin-A2

6

1

Small-scale

0.730

High

625651

CDK2
Cyclin-dependent kinase 2

4

1

Small-scale

0.694

High

1377765

DCAF1
DDB1- and CUL4-associated factor 1

4

1

Small-scale

0.692

High

415117

CDK1
Cyclin-dependent kinase 1

4

1

Small-scale

0.680

High

835578

GSK3A
Glycogen synthase kinase-3 alpha

2

2

High-throughput

0.628

High

836111

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.628

High

1042909

CUL3
Cullin-3

2

3

High-throughput

0.611

High

782312

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.602

High

1069832

NONO
Non-POU domain-containing octamer-binding protein

2

0

Small-scale

0.598

High

1262767

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

Small-scale

0.589

High

780373

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

529953

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

886025

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.561

High

229147

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1082466

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

585099

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

932930

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.549

High

1273983

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.537

High

305052

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.536

High

1041514

CUL2
Cullin-2

1

3

High-throughput

0.536

High

1185020

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

1274091

CUL5
Cullin-5

1

3

High-throughput

0.536

High

1377764

MTCL1
Microtubule cross-linking factor 1

1

1

High-throughput

0.536

High

1130766

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

277863

DYSF
Dysferlin

1

0

High-throughput

0.518

High

118805

AIP
AH receptor-interacting protein

1

0

High-throughput

0.513

High

672366

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

973805

AKA12
A-kinase anchor protein 12

1

0

High-throughput

0.513

High

1030209

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

1075781

SF01
Splicing factor 1

1

0

High-throughput

0.513

High

1082552

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

High-throughput

0.513

High

1116825

HSF5
Heat shock factor protein 5

1

0

High-throughput

0.513

High

1160792

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.513

High

1197784

DSG4
Desmoglein-4

1

0

High-throughput

0.513

High

1205569

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1219147

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1295509

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1304543

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

High-throughput

0.513

High

1316042

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

1327814

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

1328650

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1329714

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.513

High

1334636

ZMAT3
Zinc finger matrin-type protein 3

1

0

High-throughput

0.513

High

1350476

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.513

High

1377766

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

1377767

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

1377769

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

1253631

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

301341

MTCL2
Microtubule cross-linking factor 2

1

1

High-throughput

0.489

High

1240148

RDH13
Retinol dehydrogenase 13

1

1

High-throughput

0.489

High

396108

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

892134

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.480

High

902818

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1377704

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

92344

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

364631

TRFE
Serotransferrin

1

1

Small-scale

0.479

High

364760

TRFL
Lactotransferrin

1

1

Small-scale

0.479

High

385773

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

456029

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

850245

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

901910

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

High-throughput

0.479

High

943812

CCNA1
Cyclin-A1

1

1

Small-scale

0.479

High

974711

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1030056

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1043324

CUL4A
Cullin-4A

1

3

Small-scale

0.479

High

1049197

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

1092948

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

Small-scale

0.479

High

1172402

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1273001

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

1

High-throughput

0.479

High

1281507

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1281886

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1286260

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

1301927

CCNL2
Cyclin-L2

1

1

Small-scale

0.479

High

1304209

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1305991

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.479

High

1319035

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

1335052

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1349051

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1356379

FBW1B
F-box/WD repeat-containing protein 11

1

1

Small-scale

0.479

High

1357338

UBP18
Ubl carboxyl-terminal hydrolase 18

1

1

Small-scale

0.479

High

1377771

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

149787

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

326836

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

339184

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

344730

CO3
Complement C3

1

0

Small-scale

0.458

High

375142

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

378599

OAT
Ornithine aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

443897

VIME
Vimentin

1

0

Small-scale

0.458

High

505003

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

570221

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

582579

NUCL
Nucleolin

1

0

Small-scale

0.458

High

641993

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

644209

EF1G
Elongation factor 1-gamma

1

0

Small-scale

0.458

High

652693

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

669497

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

685131

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

719261

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

721862

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

853529

IMA1
Importin subunit alpha-1

1

0

Small-scale

0.458

High

867909

HIRA
Protein HIRA

1

0

Small-scale

0.458

High

875466

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

887990

CD81
CD81 antigen

1

0

High-throughput

0.458

High

907195

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

909384

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

921487

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

923814

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

Small-scale

0.458

High

933679

TBA4A
Tubulin alpha-4A chain

1

0

Small-scale

0.458

High

980036

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.458

High

1027835

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

1031309

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1036237

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1047013

BYST
Bystin

1

0

Small-scale

0.458

High

1060979

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1080515

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1085732

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1110506

GON4L
GON-4-like protein

1

0

Small-scale

0.458

High

1148897

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1166098

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1189091

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1230946

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1245242

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1270539

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1286508

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1286767

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1287949

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

Small-scale

0.458

High

1305795

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

1314434

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1316845

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1327170

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1331708

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1332807

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1342859

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1354713

ABCF2
ATP-binding cassette sub-family F member 2

1

0

Small-scale

0.458

High

1354976

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1356801

DNPEP
Aspartyl aminopeptidase

1

0

Small-scale

0.458

High

1377768

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.458

High

111234

J3KMX2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

1

1

High-throughput

0.445

High

609628

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.445

High

1133055

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

1348467

FA13B
Protein FAM13B

1

2

Small-scale

0.439

High

1140869

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1330899

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

1377770

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

2

High-throughput

0.437

High

963709

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

1318908

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

99753

F5H6I0
Beta-2-microglobulin

1

1

High-throughput

0.407

High

883685

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1326226

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.407

High

1328074

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.407

High

1330684

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

High-throughput

0.407

High

968951

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

995474

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

1028300

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1034568

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

1253063

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1355712

TSP50
Probable threonine protease PRSS50

1

0

High-throughput

0.279

Low

199564

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

0

Small-scale

0.249

Low

344255

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.249

Low

352328

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

606506

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.249

Low

894694

DEST
Destrin

1

0

Small-scale

0.249

Low

1187993

NRK
Nik-related protein kinase

1

0

Small-scale

0.249

Low

1229882

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

1328919

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

1347000

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

1357025

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1172

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

110828

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low

968673

TAGL
Transgelin

1

0

High-throughput

0.232

Low

1169481

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024