Protein: MIC25
MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6)

Gene: MIC25, CHCHD6
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q9BRQ6

Gene Ontology (top 5):
GO:0001401 - SAM complex
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005829 - cytosol
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

281650

MTX2
Metaxin-2

5

4

High-throughput

0.716

High

1291764

S22AG
Solute carrier family 22 member 16

3

1

High-throughput

0.662

High

1411603

MIC19
MICOS complex subunit MIC19

3

4

High-throughput

0.662

High

1411615

SAM50
Sorting and assembly machinery component 50 homolog

3

2

High-throughput

0.653

High

1411604

CLC5A
C-type lectin domain family 5 member A

3

0

High-throughput

0.638

High

1411599

SFXN1
Sideroflexin-1

3

1

High-throughput

0.633

High

1250107

MIC27
MICOS complex subunit MIC27

2

5

High-throughput

0.611

High

1411594

CD244
Natural killer cell receptor 2B4

3

1

High-throughput

0.604

High

1411609

TRAK1
Trafficking kinesin-binding protein 1

2

3

High-throughput

0.601

High

1164534

MIC60
MICOS complex subunit MIC60

2

2

Small-scale

0.571

High

1216396

FAXC
Failed axon connections homolog

2

4

High-throughput

0.549

High

244868

TRAK2
Trafficking kinesin-binding protein 2

1

3

High-throughput

0.536

High

538670

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.536

High

574115

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

3

High-throughput

0.536

High

901528

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.536

High

1382373

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.536

High

1411607

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1411613

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

1350870

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

967944

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.501

High

166026

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

182748

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

886313

ARL4D
ADP-ribosylation factor-like protein 4D

1

1

High-throughput

0.489

High

1291877

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

1

High-throughput

0.489

High

1326887

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.489

High

1411605

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

1

High-throughput

0.489

High

423001

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1411614

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

216798

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.479

High

223293

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

245524

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

292210

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

296290

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

348692

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

372997

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

447371

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

508529

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

560071

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

714388

PML
Protein PML

1

2

High-throughput

0.479

High

1035876

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1140767

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1149617

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1220528

MIC13
MICOS complex subunit MIC13

1

1

High-throughput

0.479

High

1270619

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

1382924

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

1388577

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.479

High

1397155

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

4

High-throughput

0.479

High

1397636

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.479

High

1406005

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1411592

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.479

High

1411593

MIC26
MICOS complex subunit MIC26

1

5

High-throughput

0.479

High

1411596

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

1411597

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1411600

PLRKT
Plasminogen receptor

1

1

High-throughput

0.479

High

1411601

ANLN
Anillin

1

1

High-throughput

0.479

High

1411602

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.479

High

1411608

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

653535

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

1411616

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.445

High

331272

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.437

High

1411598

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1411606

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

1311163

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.426

High

158588

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

1

High-throughput

0.407

High

1180310

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.407

High

1280808

S35E3
Solute carrier family 35 member E3

1

1

High-throughput

0.407

High

1350595

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

2

High-throughput

0.407

High

1399237

PCFT
Proton-coupled folate transporter

1

2

High-throughput

0.407

High

1411595

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

1

High-throughput

0.407

High

1411611

S35A3
UDP-N-acetylglucosamine transporter

1

2

High-throughput

0.407

High

1411612

KLDC2
Kelch domain-containing protein 2

1

1

High-throughput

0.407

High

845115

EAA3
Excitatory amino acid transporter 3

2

0

High-throughput

0.313

High

848558

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.313

High

154870

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.279

Low

231810

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.279

Low

638236

S1PR1
Sphingosine 1-phosphate receptor 1

1

0

High-throughput

0.279

Low

771219

APJ
Apelin receptor

1

0

High-throughput

0.279

Low

880194

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1034811

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1310021

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1317081

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.279

Low

1325908

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1336522

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

1358928

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.279

Low

1411610

INVS
Inversin

1

0

High-throughput

0.279

Low

1281670

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.269

Low

1239039

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.232

Low

1389572

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025