Protein: TIGAR
Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)

Gene: TIGAR
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q9NQ88

Gene Ontology (top 5):
GO:0000423 - mitophagy
GO:0002931 - response to ischemia
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085926

TWF1
Twinfilin-1

2

1

High-throughput

0.621

High

834265

PLPL4
Patatin-like phospholipase domain-containing protein 4

2

0

High-throughput

0.602

High

1156706

NF2L2
Nuclear factor erythroid 2-related factor 2

1

2

Small-scale

0.561

High

733444

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

946460

MTPN
Myotrophin

1

2

High-throughput

0.536

High

1446859

KLK13
Kallikrein-13

1

1

High-throughput

0.536

High

914122

HXK2
Hexokinase-2

1

4

Small-scale

0.534

High

985905

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.518

High

131020

HIP1
Huntingtin-interacting protein 1

1

2

High-throughput

0.515

High

1446863

SHLB1
Endophilin-B1

1

2

High-throughput

0.515

High

1101242

NMI
N-myc-interactor

1

0

High-throughput

0.513

High

1310441

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1434428

GSX1
GS homeobox 1

1

0

High-throughput

0.513

High

1446858

PHF11
PHD finger protein 11

1

0

High-throughput

0.513

High

1446865

NGN3
Neurogenin-3

1

0

High-throughput

0.513

High

423255

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

937116

CASP6
Caspase-6

1

0

High-throughput

0.493

High

132318

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

243019

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

535573

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

589774

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

696589

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

942909

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

986747

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1255670

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1333020

F184A
Protein FAM184A

1

1

High-throughput

0.479

High

1389395

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

Small-scale

0.479

High

1420363

TRI31
E3 ubiquitin-protein ligase TRIM31

1

9

Small-scale

0.479

High

1446857

DNJB4
DnaJ homolog subfamily B member 4

1

4

High-throughput

0.479

High

1446860

TRI35
E3 ubiquitin-protein ligase TRIM35

1

2

Small-scale

0.479

High

290165

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

1276828

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1339189

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1429985

SHRPN
Sharpin

1

0

Small-scale

0.458

High

1446855

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

326904

ARK73
Aldo-keto reductase family 7 member A3

1

4

High-throughput

0.445

High

469839

CATG
Cathepsin G

1

2

High-throughput

0.445

High

1209692

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1356711

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

3

High-throughput

0.445

High

1418401

PCGF6
Polycomb group RING finger protein 6

1

3

High-throughput

0.445

High

1446854

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

769259

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

125622

LEG9
Galectin-9

1

0

High-throughput

0.426

High

598779

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1010781

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.426

High

1446861

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

1446864

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.426

High

628654

CAP7
Azurocidin

1

3

High-throughput

0.407

High

1328131

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

1446853

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.407

High

1380540

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

1408236

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

1415406

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.279

Low

1446862

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

562424

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

379401

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.232

Low

1392412

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1435012

TM231
Transmembrane protein 231

1

0

High-throughput

0.232

Low

1446856

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025