Protein: ORC6
Origin recognition complex subunit 6

Gene: ORC6
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9Y5N6

Gene Ontology (top 5):
GO:0000808 - origin recognition complex
GO:0001650 - fibrillar center
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104382

ORC2
Origin recognition complex subunit 2

8

2

Small-scale

0.751

High

1458321

ORC3
Origin recognition complex subunit 3

5

2

Small-scale

0.722

High

1379978

LHX4
LIM/homeobox protein Lhx4

5

2

High-throughput

0.717

High

231536

ORC4
Origin recognition complex subunit 4

4

6

Small-scale

0.699

High

1406969

CDC6
Cell division control protein 6 homolog

1

6

High-throughput

0.692

High

133390

DCTN6
Dynactin subunit 6

3

0

High-throughput

0.638

High

593255

CREB1
Cyclic AMP-responsive element-binding protein 1

3

0

High-throughput

0.638

High

1350517

BICD2
Protein bicaudal D homolog 2

3

0

High-throughput

0.638

High

1459108

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

3

0

High-throughput

0.638

High

755832

MCM4
DNA replication licensing factor MCM4

2

4

Small-scale

0.614

High

1360544

PSPC1
Paraspeckle component 1

2

1

High-throughput

0.611

High

1401195

SPAG5
Sperm-associated antigen 5

2

0

High-throughput

0.601

High

230930

ORC5
Origin recognition complex subunit 5

2

9

Small-scale

0.594

High

132531

CDC7
Cell division cycle 7-related protein kinase

2

0

Small-scale

0.588

High

1356422

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

0

High-throughput

0.585

High

601921

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.554

High

756430

MCM7
DNA replication licensing factor MCM7

1

4

High-throughput

0.536

High

888419

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.536

High

1128320

MCM6
DNA replication licensing factor MCM6

1

4

High-throughput

0.536

High

1458743

DBF4A
Protein DBF4 homolog A

1

0

Small-scale

0.529

High

407740

S100B
Protein S100-B

1

0

High-throughput

0.513

High

1491306

PYGO1
Pygopus homolog 1

1

0

High-throughput

0.513

High

756100

MCM5
DNA replication licensing factor MCM5

1

4

Small-scale

0.481

High

423540

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1150034

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.480

High

1431425

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.479

High

139034

BCL9
B-cell CLL/lymphoma 9 protein

1

1

High-throughput

0.479

High

558523

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

559553

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

655391

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.479

High

1010798

SSBP2
Single-stranded DNA-binding protein 2

1

1

High-throughput

0.479

High

1289060

BCL9L
B-cell CLL/lymphoma 9-like protein

1

1

High-throughput

0.479

High

1382438

ISL2
Insulin gene enhancer protein ISL-2

1

2

High-throughput

0.479

High

1416439

SSBP3
Single-stranded DNA-binding protein 3

1

1

High-throughput

0.479

High

281271

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.460

High

696984

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.460

High

404572

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

1111393

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.458

High

1287942

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.458

High

1404548

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1452955

ARP10
Actin-related protein 10

1

0

High-throughput

0.458

High

965531

LMO4
LIM domain transcription factor LMO4

1

2

High-throughput

0.437

High

887386

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

66912

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

1384741

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

608395

EGLN
Endoglin

1

0

High-throughput

0.261

Low

1458978

CFDP1
Craniofacial development protein 1

1

0

High-throughput

0.249

Low

1316226

S22AF
Solute carrier family 22 member 15

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025